Výsledky vyhledávání - "Peter Reinink"

Akademický článek

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Autor: Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derive

Externí odkaz: https://doaj.org/article/8b688ab776554395acd758b05b541c3e

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Akademický článek

Large-Scale Identification of Coregulated Enhancer Networks in the Adult Human Brain

Autor: Marit W. Vermunt, Peter Reinink, Jeroen Korving, Ewart de Bruijn, Paul M. Creyghton, Onur Basak, Geert Geeven, Pim W. Toonen, Nico Lansu, Charles Meunier, Sebastiaan van Heesch, Hans Clevers, Wouter de Laat, Edwin Cuppen, Menno P. Creyghton

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 767-779 (2014)

Understanding the complexity of the human brain and its functional diversity remain a major challenge. Distinct anatomical regions are involved in an array of processes, including organismal homeostasis, cognitive functions, and susceptibility to neu

Externí odkaz: https://doaj.org/article/f2a52140da1e424a8aff2a3ac40ccfd4

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Akademický článek

Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.

Autor: Thi Kim Anh Nguyen, Peter Reinink, Chema El Messlaki, Jin S Im, Altan Ercan, Steven A Porcelli, Ildiko Van Rhijn

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121923 (2015)

Research addressing the in vivo effects of T cell activation by lipids, glycolipids, and lipopeptides is hampered by the absence of a suitable animal model. Mice and rats do not express CD1a, CD1b, and CD1c molecules that present pathogen-derived lip

Externí odkaz: https://doaj.org/article/3c8411347f594427ae265214284fc383

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Akademický článek

Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies.

Autor: Thi Kim Anh Nguyen, Peter Reinink, Chema El Messlaki, Jin S Im, Altan Ercan, Steven A Porcelli, Ildiko Van Rhijn

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129755 (2015)

Externí odkaz: https://doaj.org/article/c13046cb5d404439a1fb8831e8355f7b

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Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria

Autor: Sho Yamasaki, D. Branch Moody, Jacob A. Mayfield, Cécile A. van Els, Michael McClelland, Steffen Porwollik, Ildiko Van Rhijn, Gordon Dougan, Patrick J. Brennan, Eri Ishikawa, Adriaan J. Minnaard, Peter Reinink, Eva Heinz, Vivek K. Mishra, Tan-Yun Cheng, Jeffrey Buter, Peter Willemsen, Giorgio Napolitani, Vincenzo Cerundolo

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 216(4), 757-771. ROCKEFELLER UNIV PRESS
The Journal of experimental medicine 216 (2019) 4
The Journal of experimental medicine, vol 216, iss 4
Journal of Experimental Medicine, 216(4). Rockefeller University Press
The Journal of experimental medicine, 216(4), 757-771

This work describes the discovery, biosynthesis, and chemical synthesis of a previously unknown class of lipids, trehalose phospholipids, in pathogenic Salmonella species. Trehalose phospholipids stimulate the innate immune receptor Mincle, the recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1980a47a889f3a0a75655c276fe9495c
https://doi.org/10.1084/jem.20181812

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CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

Publikováno v: Cell Chemical Biology, 25(4), 392-402.e14. CELL PRESS
Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2018, 25 (4), pp.392-402.e14. ⟨10.1016/j.chembiol.2018.01.006⟩
James, C A, Yu, K K Q, Gilleron, M, Prandi, J, Yedulla, V R, Moleda, Z Z, Diamanti, E, Khan, M, Aggarwal, V K, Reijneveld, J F, Reinink, P, Lenz, S, Emerson, R O, Scriba, T J, Souter, M N T, Godfrey, D I, Pellicci, D G, Moody, D B, Minnaard, A J, Seshadri, C & Van Rhijn, I 2018, ' CD1b tetramers identify T cells that recognize natural and synthetic diacylated sulfoglycolipids from mycobacterium tuberculosis ', Cell Chemical Biology, vol. 25, no. 4, pp. 392-402.e14 . https://doi.org/10.1016/j.chembiol.2018.01.006

Mycobacterial cell wall lipids bind the conserved CD1 family of antigen-presenting molecules and activate T cells via their T cell receptors (TCRs). Sulfoglycolipids (SGLs) are uniquely synthesized by Mycobacterium tuberculosis, but tools to study SG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd030b1c8830816e59dd5ba5035d093
https://research.rug.nl/en/publications/8014231c-9253-42d1-8bfb-4958487144b4

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A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins

Autor: Rachel Farquhar, Leonid Lecca, Adam Shahine, Roger Calderon, Tan Yun Cheng, Jamie Rossjohn, D. Branch Moody, Ildiko Van Rhijn, Kattya Lopez, Jérôme Le Nours, Li Lynn Tan, Stephanie Gras, Sara Suliman, Judith Jimenez, Peter Reinink, Josephine F. Reijneveld, Megan Murray, Segundo R. Leon

Publikováno v: Journal of Immunology, 203(12), 3395. American Association of Immunologists
Journal of Immunology, 203(12), 3395-3406. AMER ASSOC IMMUNOLOGISTS

High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e577fb83d1eb48dd8ae89538e65ebc0b
https://dspace.library.uu.nl/handle/1874/389155

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Author response for 'CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells'

Autor: Michael N. T. Souter, Tan-Yun Cheng, Daniel G. Pellicci, D. Branch Moody, Peter Reinink, Kristin Kremer, Allen C. Steere, Dale I. Godfrey, Steven F. T. Thijsen, Tamara van Gorkom, Joanna Kubler-Kielb, Klemen Strle, Ildiko Van Rhijn, Stefanie Lenz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec3ef281206dba87347f0b06326f8a3
https://doi.org/10.1002/eji.201847949/v2/response1

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A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Autor: John D. Altman, Jamie Rossjohn, Joanna Kubler-Kielb, Adriaan J. Minnaard, Ildiko Van Rhijn, Peter Reinink, Jacques Prandi, Stephanie Gras, D. Branch Moody, Stefanie Lenz, Mira Holzheimer, Josephine F. Reijneveld, Adam Shahine, Tan Yun Cheng

Publikováno v: Nature Communications, 10(1). Nature Publishing Group
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):56. Nature Publishing Group

CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33484f5094573428e5a1e26d6e244fe3
https://dspace.library.uu.nl/handle/1874/377907

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