Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peter Reifsnyder"'
Autor:
Richard A. Miller, David E. Harrison, David B. Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A. Javors, Warren C. Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A. Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith Jr., Jessica M. Snyder, David B. Lombard, Randy Strong
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://doaj.org/article/8346a43abd5742d2afbdcea95b0aa4d1
Autor:
Randy Strong, Richard A. Miller, Catherine J. Cheng, James F. Nelson, Jonathan Gelfond, Shailaja Kesaraju Allani, Vivian Diaz, Angela Olsen Dorigatti, Jonathan Dorigatti, Elizabeth Fernandez, Andrzej Galecki, Brett Ginsburg, Karyn L. Hamilton, Martin A. Javors, Kerry Kornfeld, Matt Kaeberlein, Suja Kumar, David B. Lombard, Marisa Lopez‐Cruzan, Benjamin F. Miller, Peter Rabinovitch, Peter Reifsnyder, Nadia A. Rosenthal, Molly A. Bogue, Adam B. Salmon, Yousin Suh, Eric Verdin, Herbert Weissbach, John Newman, Francesca Maccchiarini, David E. Harrison
Publikováno v:
Aging Cell. 21
Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2-activating botanical mixture PB125, sulindac, syringaresinol, or the combination of
Autor:
David E. Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, Marisa Lopez‐Cruzan, Francesca Macchiarini, James F. Nelson, Adrian Markewych, Alessandro Bitto, Amy L. Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M. Stearns, Molly Bogue, Richard A. Miller
Publikováno v:
Aging Cell
Aging cell, vol 20, iss 5
Aging cell, vol 20, iss 5
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p
Interventions that increase lifespan when started late in life ar
Interventions that increase lifespan when started late in life ar
Autor:
Michael P. Murphy, James F. Nelson, Elizabeth Fernandez, Arlan Richardson, David E. Harrison, Richard A. Miller, Peter Reifsnyder, Molly A. Bogue, Adam B. Salmon, Martin A. Javors, Nicolas Musi, Randy Strong, Michael Petrascheck, Paul Anthony Marinez, Francesca Macchiarini, Sergiy Libert
Publikováno v:
Aging Cell
To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in
Autor:
Francesca Macchiarini, Molly A. Bogue, Jessica M. Snyder, Nadia Rosenthal, Peter Reifsnyder, Andrzej T. Galecki, James F. Nelson, Warren C Ladies, Richard A. Miller, David B. Allison, Martin A. Javors, Daniel L. Smith, Randy Strong, Elizabeth Fernandez, Vivian Diaz, Navasuja Kumar, David E. Harrison, W. Timothy Garvey, Adam B. Salmon, David B. Lombard
Canagliflozin (Cana) is an inhibitor of the sodium glucose transporter 2 (SGLT2), and is thought to act by blocking renal reuptake and intestinal absorption of glucose. Cana is FDA-approved for treatment of diabetes, and affords protection from cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d7c952dcb41918aa25bca60e14631f
https://doi.org/10.1101/2020.05.23.112763
https://doi.org/10.1101/2020.05.23.112763
Autor:
Kathi Burke, Peter Reifsnyder
Summary: Albuwell M is an indirect competitive ELISA designed to monitor kidney function in the mouse by measurement of urinary albumin. To complete the assay, sample and rabbit anti-murine albumin antibody are added to albumin coated wells. The anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc5d808345e6bc3bf008daa6b5027dc
https://doi.org/10.17504/protocols.io.34mgqu6
https://doi.org/10.17504/protocols.io.34mgqu6
Summary: This assay is designed for companion use with Exocell’s immunospecific ELISAs for urine albumin excretion, allowing expression of results as µg albumin per mg creatinine in the urine. Adaptation of creatinine measurement to microtiter wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2dd5da117b9dc148b2cf9f932c927d
https://doi.org/10.17504/protocols.io.3fmgjk6
https://doi.org/10.17504/protocols.io.3fmgjk6
Autor:
Peter, Reifsnyder, William, Schott, Darcy, Pomerleau, Mark D, Lessard, Brian W, Soper, Edward H, Leiter
Publikováno v:
Novartis Foundation symposium. 292
The major histocompatibility complex (MHC) of the type 1 diabetes-prone NOD mouse lacks a functional class II H2-Ea gene such that antigen presenting cells (APCs) are I-E null. Transgenic expression of Ea in NOD mice both restores I-E expression and