Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Peter R. Wills"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108977- (2024)
Summary: The Michaelis-Menten model requires its reaction velocities to come from a preparation of homogeneous enzymes, with identical or near-identical catalytic activities. However, this condition is not always met. We introduce a kinetic model tha
Externí odkaz:
https://doaj.org/article/3e4be62b203843e3ab15036bb1390c16
Autor:
Peter R. Wills
Publikováno v:
Entropy, Vol 25, Iss 9, p 1281 (2023)
The origin of genetic coding is characterised as an event of cosmic significance in which quantum mechanical causation was transcended by constructive computation. Computational causation entered the physico-chemical processes of the pre-biotic world
Externí odkaz:
https://doaj.org/article/0272974c042f4760bad32def66a859ff
Publikováno v:
New Zealand Geographer. 79:27-32
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1520 (2022)
The role of aminoacyl-tRNA synthetases (aaRS) in the emergence and evolution of genetic coding poses challenging questions concerning their provenance. We seek evidence about their ancestry from curated structure-based multiple sequence alignments of
Externí odkaz:
https://doaj.org/article/f602687811444b97b6460796f5d35070
How genetic information gained its exquisite control over chemical processes needed to build living cells remains an enigma. Today, the aminoacyl-tRNA synthetases (AARS) execute the genetic codes in all living systems. But how did the AARS that emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4788b17f08b5d832c991ec932d0b3e
https://doi.org/10.21203/rs.3.rs-2924681/v1
https://doi.org/10.21203/rs.3.rs-2924681/v1
Autor:
Charles W. Carter, Peter R. Wills
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 265 (2021)
Bioenergetics, genetic coding, and catalysis are all difficult to imagine emerging without pre-existing historical context. That context is often posed as a “Chicken and Egg” problem; its resolution is concisely described by de Grasse Tyson: “T
Externí odkaz:
https://doaj.org/article/697a65064956466f8e95c4c28cd5568e
Autor:
Peter R. Wills, Charles W. Carter
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7392 (2020)
We recently observed that errors in gene replication and translation could be seen qualitatively to behave analogously to the impedances in acoustical and electronic energy transducing systems. We develop here quantitative relationships necessary to
Externí odkaz:
https://doaj.org/article/371a6bbfa07e4f8eb7db1353529cd92e
Publikováno v:
Journal of Molecular Evolution. 88:136-150
The underlying structure of the canonical amino acid substitution matrix (aaSM) is examined by considering stepwise improvements in the differential recognition of amino acids according to their chemical properties during the branching history of the
The provenance of the aminoacyl-tRNA synthetases (aaRS) poses unusually challenging questions because of their role in the emergence and evolution of genetic coding. We investigate evidence about their ancestry from highly curated structure-based mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b851c5a1ad115459b661a97b0830bdde
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1520
International Journal of Molecular Sciences, Vol 23, Iss 1520, p 1520 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 1520, p 1520 (2022)
The role of aminoacyl-tRNA synthetases (aaRS) in the emergence and evolution of genetic coding poses challenging questions concerning their provenance. We seek evidence about their ancestry from curated structure-based multiple sequence alignments of