Electron Transfer Coupled to Conformational Dynamics in Cell Respiration

Autor: Marco Reidelbach, Christoph Zimmer, Brigitte Meunier, Peter R. Rich, Vivek Sharma

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Cellular respiration is a fundamental process required for energy production in many organisms. The terminal electron transfer complex in mitochondrial and many bacterial respiratory chains is cytochrome c oxidase (CcO). This converts the energy rele

Externí odkaz: https://doaj.org/article/334b15d1b632433cbf184b5fcaccb5f8

Assessment of Measurement of Salivary Urea by ATR-FTIR Spectroscopy to Screen for CKD

Autor: Tzu-Ling Lin, Rhys D.R. Evans, Robert J. Unwin, Jill T. Norman, Peter R. Rich

Publikováno v: Kidney360

Stages of CKD are currently defined by eGFR and require measurement of serum creatinine concentrations. Previous studies have shown a good correlation between salivary and serum urea levels and the stage of CKD. However, quantitative salivary urea as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8cce0ee2268316d657a88de4dd2607
https://doi.org/10.34067/kid.0004362021

A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria

Autor: Andrew M. Hartley, Francis Haraux, Peter R. Rich, Naho Genko, Jing-Yang Xu, Amandine Maréchal, Brigitte Meunier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, ⟨10.1073/pnas.2001572117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, ⟨10.1073/pnas.2001572117⟩

Significance We present a comprehensive investigation of mitochondrial DNA-encoded variants of cytochrome c oxidase (CcO) that harbor mutations within their core catalytic subunit I, designed to interrogate the presently disputed functions of the thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2e5b3ac9ff1949bfe309d6b38d5df4
https://doi.org/10.1073/pnas.2001572117

A radical-triggered reaction mechanism of the green-to-red photoconversion of EosFP

Autor: Clyde Fare, Peter R. Rich, Jasper J. van Thor, Violeta Cordon-Preciado, Jasper J. Michels, Letong Yuan, Michael J. Bearpark

Reaction intermediates in the green-to-red photoconversion of the photochromic fluorescent protein EosFP have been observed using high-intensity continuous blue illumination. An intermediate was identified through light induced accumulation that cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122d8837f827e45d56186caaf63f8435
http://hdl.handle.net/10044/1/81709

Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies

Autor: Peter R. Rich

Publikováno v: Biochemical Society Transactions. 45:813-829

Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem–copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a896e742fcf95e3e97a9e3c178d7e564
https://doi.org/10.1042/bst20160139