Výsledky vyhledávání - "Peter R. Mullins"

Use of a basal-plus insulin regimen in persons with type 2 diabetes stratified by age and body mass index: A pooled analysis of four clinical trials

Autor: Mark R Lankisch, Marie Paule Dain, Stefano Del Prato, David R. Owens, Peter R. Mullins

Publikováno v: Primary Care Diabetes. 10(1):51-59

AimsTo evaluate the efficacy and safety of adding a single bolus dose of insulin glulisine to basal insulin (‘basal-plus’) in persons with type 2 diabetes.MethodsData from patients with poor glycemic control on oral antihyperglycemic drugs who we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3386631eb501ab2d7f270556941fc614

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Reduced risk of hypoglycemia with once-daily glargine versus twice-daily NPH and number needed to harm with NPH to demonstrate the risk of one additional hypoglycemic event in type 2 diabetes: Evidence from a long-term controlled trial

Autor: Marie-Paule Dain, Stefan Schinzel, Julio Rosenstock, Peter R. Mullins, Vivian Fonseca, Matthew C. Riddle

Publikováno v: Journal of diabetes and its complications

Aims This analysis evaluated HbA 1c -adjusted hypoglycemia risk with glargine versus neutral protamine Hagedorn (NPH) over a 5-year study in patients with Type 2 diabetes mellitus (T2DM). Clinical significance was assessed using number needed to harm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d2d75d5c21f592775d31bc3648cba
http://europepmc.org/articles/PMC4802045

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A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease

Autor: Peter N. Black, Phillippa Poole, Eskandarain Shafuddin, Graham Mills, Peter R. Mullins, Mark Holmes

Publikováno v: Journal of Negative Results in Biomedicine

Background Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (at least three moderate or sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde566b0d402320846cb370a8a9b60f6
http://europepmc.org/articles/PMC4562194

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Trial of Roxithromycin in Subjects with Asthma and Serological Evidence of Infection withChlamydia pneumoniae

Autor: Raffaele Scicchitano, Peter N. Black, Graham Mills, Luigi Allegra, Abraham R. Rubinfeld, Peter R. Mullins, B. E M Denise David, Francesco Blasi, Richard E. Ruffin, Christine Jenkins, Bruce C. Cooper, Josette Dangain

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 164:536-541

An association has been reported between chronic infection with Chlamydia pneumoniae and the severity of asthma, and uncontrolled observations have suggested that treatment with antibiotics active against C. pneumoniae leads to an improvement in asth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd8015ed7d6dcaf2c459b38dafe3c91
https://doi.org/10.1164/ajrccm.164.4.2011040

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Clinical Efficacy of Roxithromycin in the Treatment of Adults with Upper and Lower Respiratory Tract Infection Due to Haemophilus influenzae

Autor: Peter R. Mullins, S. D. R. Lang, Bruce C. Cooper, M. R. Jones

Publikováno v: Drug Investigation. 7:299-314

12 clinical studies on the use of roxithromycin 300mg daily in adult respiratory tract infection were subject to meta-analysis. Nine of the studies were comparative and 5 were from the published literature. Auditable individual patient data were revi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33ca242feed7268310f3e88856adce11
https://doi.org/10.1007/bf03258472

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Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis

Autor: Greg Brown, Alan Coulthard, Barbara J. B. Johnson, Daina M. Vanags, Dennis Feeney, Simon Broadley, Lyn R. Griffiths, Bronwyn Williams, Chris Kneebone, Sepehr Shakib, Peter R. Mullins

Background Chaperonin 10 (Cpn10) is a mitochondrial molecule involved in protein folding. The aim of this study was to determine the safety profile of Cpn10 in patients with multiple sclerosis (MS). Methods A total of 50 patients with relapse-remitti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db87f333fae992fc6470c9731ad9125e
https://hdl.handle.net/11541.2/126696

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Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellitus

Autor: Matthew C. Riddle, Hans-Ulrich Häring, Hannele Yki-Järvinen, Peter R. Mullins, Peter Sharplin

Publikováno v: Clinical therapeutics. 29(8)

Objectives: This analysis first modeled the interaction between hypoglycemia and glycosylated hemoglobin (HbA2c) in clinical trials that compared insulin glargine (glargine) with human neutral protamine Hagedorn insulin (NPH) in patients with type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e8e7301f519859cc4e9711721dcbae
https://pubmed.ncbi.nlm.nih.gov/17919543

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