Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Peter R. Mullens"'
Autor:
Jianguo Yin, David A. Thaisrivongs, Zhijian Liu, Nobuyoshi Yasuda, Adrian Goodyear, Ryan D. Cohen, Antony J. Davies, Brian C. Bishop, Peter R. Mullens, Kevin R. Campos, John Limanto, Ed Cleator, John S. Edwards, Mahbub Alam, Aaron M. Dumas, Hongming Li, Jingjun Yin, Lushi Tan, Zhiguo Jake Song, Yong-Li Zhong, William J. Morris, Michael Shevlin, Edward C. Sherer
Publikováno v:
The Journal of Organic Chemistry. 84:4780-4795
An asymmetric synthesis of HCV NS5B nucleoside polymerase inhibitor (1) is described. This novel route features several remarkably diastereoselective and high-yielding transformations, including construction of the all-carbon quaternary stereogenic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e13257ca1892584b4baff0f89a4446
https://doi.org/10.1021/acs.joc.8b02500
https://doi.org/10.1021/acs.joc.8b02500
Autor:
Justin Belardi, Lushi Tan, Bangping Xiang, Nobuyoshi Yasuda, Ed Cleator, John S Edwards, Chen Frank, Lisa DiMichele, Kevin M. Belyk, Fabien L. Cabirol, Scott S. Ceglia, Jianguo Yin, Shen-Chun Kuo, Peter R Mullens, Weng Lin Tang, Adrian Goodyear, Guiquan Liu, Zhiguo Jake Song, Robert A. Reamer, Birgit Kosjek, Brian Bishop
Publikováno v:
Organic Process Research & Development. 21:1851-1858
The development of a scalable asymmetric route to a new calcitonin gene-related peptide (CGRP) receptor antagonist is described. The synthesis of the two key fragments was redefined, and the intermediates were accessed through novel chemistry. Chiral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4130076f382fd9dc4295a7c462f7cec4
https://doi.org/10.1021/acs.oprd.7b00293
https://doi.org/10.1021/acs.oprd.7b00293
Autor:
John S. Edwards, Teresa Andreani, Michael Williams, Hongmei Li, Jongrock Kong, Peter R. Mullens, Brian C. Bishop, Ed Cleator, Adrian Goodyear, Michael J. Zacuto, Yan Jin, Mark McLaughlin
Publikováno v:
Organic Process Research & Development. 20:1075-1087
Two new routes to a pyrimidyl tetrazole intermediate are described. The first-generation route featured an iron-catalyzed cross-coupling between 4-butenylmagnesium bromide and a 4-chloropyrimidine derivative to afford an alkene-bearing pyrimidine int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d61592180531de92bc4c27b0895e0f
https://doi.org/10.1021/acs.oprd.6b00136
https://doi.org/10.1021/acs.oprd.6b00136
Autor:
Melissa E. Howard, Andrew W. Gibson, Alejandro Dieguez-Vazquez, Debra J. Wallace, Artis Klapars, Robert D. Wilson, Jeremy P. Scott, Peter R. Mullens, Andrew D. Gibb, Carl A. Baxter, Jaemoon Lee, Sarah E. Brewer, Stephen P. Keen, Ed Cleator, Nadine Bremeyer, Anthony Alorati, Kevin R. Campos, Matthew L. Maddess, Joseph J. Lynch, Jing Li
Publikováno v:
Organic Process Research & Development. 18:528-538
The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10,11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdefbcc65171430752e7a0100c3ac289
https://doi.org/10.1021/op5000489
https://doi.org/10.1021/op5000489
Publikováno v:
Organic Process Research & Development. 16:1947-1952
The efficient synthesis of a key trisubstituted indole intermediate 1 is described. The synthetic route required the use of an aryl Grignard reagent which was not commercially available, and the large-scale formation of this fragment and the thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4639b0064e73cc0c9986c12c921a0cc6
https://doi.org/10.1021/op300303p
https://doi.org/10.1021/op300303p
Autor:
Simon Adrian Johnson, Mary M. Kim, Fred J. Fleitz, Khateeta M. Emerson, Ephraim M. Bassan, Carl A. Baxter, Gregory L. Beutner, Jeffrey T. Kuethe, Leonard William, Stephen P. Keen, Peter R. Mullens, Nobuyoshi Yasuda, Christopher Roberge, Daniel J. Muzzio
Publikováno v:
Organic Process Research & Development. 16:87-95
A six-step route starting from a readily available vinyl boronate was identified to produce an enantioenriched cyclopropanol in an overall 16% yield. Key steps involve the use of lithium acetylide-ethylene diamine complex 5 and an enzymatic resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fe79d87e5f339f77b907de6f33b712
https://doi.org/10.1021/op2002497
https://doi.org/10.1021/op2002497
Autor:
Paul Fernandez, Weifeng Hu, Peter Sajonz, Karel J. M. Brands, Jennifer R. Foley, Peter R. Mullens, Lushi Tan, George Zhou, Nadine Bremeyer, Robert D. Wilson, Sarah E. Brewer, Daniel J. Muzzio, Guoyue Zhou, Debra J. Wallace, Khateeta M. Emerson, Richard Desmond, Stephen P. Keen, Carl A. Baxter
Publikováno v:
Organic Process Research & Development. 15:831-840
Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f282e65dc38e0c3e06307cc29e3d06
https://doi.org/10.1021/op2000783
https://doi.org/10.1021/op2000783
Autor:
Antony J. Davies, Jason D. Katz, Andrew W. Gibson, Sarah E. Brewer, Stephen P. Keen, Simon E. Hamilton, Debra J. Wallace, Jeremy P. Scott, Christopher Wise, Cameron J. Cowden, Peter R. Mullens, Gavin W. Stewart, Karel M. J. Brands, John S. Edwards
Publikováno v:
Organic Process Research & Development. 14:849-858
A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd9af518581b577a8ae5e2950a75d4a
https://doi.org/10.1021/op100101q
https://doi.org/10.1021/op100101q
Autor:
Peter R. Mullens
Publikováno v:
Tetrahedron Letters. 50:6783-6786
An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester via isolation of the corresponding lithium hydroxy ate complex is described. The hydroxy ate complex is available in one pot from 4-bromo-1-methyl-1H-pyrazole and triisopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf1ec0bbd8e73d86c3ebc2cf6bfac27
https://doi.org/10.1016/j.tetlet.2009.09.105
https://doi.org/10.1016/j.tetlet.2009.09.105
Autor:
Peter R. Mullens
Publikováno v:
ChemInform. 41
An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester via isolation of the corresponding lithium hydroxy ate complex is described. The hydroxy ate complex is available in one pot from 4-bromo-1-methyl-1H-pyrazole and triisopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d270db59911fa3517876c12d0dcc247a
https://doi.org/10.1002/chin.201012115
https://doi.org/10.1002/chin.201012115