Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Peter R. Maycox"'
Autor:
Steven R. Hirsch, Jörn E. Schroeder, Claire Angelinetta, Juliet Reid, Adam Taylor, Ann M. Mortimer, Mark Lennon, Ceri H. Davies, Thomas R. E. Barnes, Peter R. Maycox, Neil A. Jones, Jackie de Belleroche, Stewart Bates, Fiona M. Kelly, Tariq Akbar, James N.C. Kew, Carol A. Scorer, Amy Thornber, Julie Huxley-Jones, Michael R. Barnes, Jim J. Hagan
Publikováno v:
Journal of Neuroscience Research. 89:1218-1227
The molecular basis of schizophrenia is poorly understood; however, different brain regions are believed to play distinct roles in disease symptomology. We have studied gene expression in the superior temporal cortex (Brodmann area 22; BA22), which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf20d312ca421caf58a70a3ba0a7daa5
https://doi.org/10.1002/jnr.22647
https://doi.org/10.1002/jnr.22647
Autor:
Julie Huxley-Jones, Fiona M. Kelly, Sarah Jugurnauth, David St Clair, James N.C. Kew, Inti Pederoso, David J. Dow, Jamie M. Hall, Israel S. Gloger, Michael R. Barnes, Peter R. Maycox, Dan Rujescu, Clyde Francks, Pierandrea Muglia, Gerome Breen, Nalini Mehta
Publikováno v:
Schizophrenia Research
We previously reported an association with a putative functional variant in the ADAMTSL3 gene, just below genome-wide significance in a genome-wide association study of schizophrenia. As variants impacting the function of ADAMTSL3 (a disintegrin-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ebc12086c4b736ce7229786c960ce
https://doi.org/10.1016/j.schres.2010.12.009
https://doi.org/10.1016/j.schres.2010.12.009
Autor:
Sabine Bahn, Dan Ma, Tsz M. Tsang, Isabel M Benzel, Declan N C Jones, Gerard A McLoughlin, Elaine Holmes, Jackie Cilia, Melanie J Robbins, Mark D Hill, Peter R Maycox
Publikováno v:
Journal of Proteome Research. 8:1943-1952
The mechanism of action of standard drug treatments for psychiatric disorders remains fundamentally unknown, despite intensive investigation in academia and the pharmaceutical industry. So far, little is known about the effects of psychotropic medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc807541c523c7339360d4ebb80e68b6
https://doi.org/10.1021/pr800892u
https://doi.org/10.1021/pr800892u
Autor:
Peter R. Maycox, Nigel E. Austin, Melanie J. Robbins, Susan H. Moore, Kevin M. Savage, Declan N.C. Jones, Mikhail Kalinichev, Elizabeth M. Hartfield
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:414-422
In a putative model of acute phencyclidine (PCP)-induced psychosis we evaluated effects of the drug on locomotor activity (LMA) and immediate early gene (IEG) induction in the rat using two routes of drug administration, intraperitoneal (i.p.) and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015295807724ef58fedb0fb1ad70e325
https://doi.org/10.1016/j.pnpbp.2007.09.008
https://doi.org/10.1016/j.pnpbp.2007.09.008
Autor:
James N.C. Kew, Peter R. Maycox, Ellen M. Soffin, Rosemary A. Melarange, Andrew Jonathan Harris, Melanie J. Robbins, Claire Rourke, Jay Strum, Fiona M. Kelly, Magalie Rocheville, Gareth A. Jones, Declan N.C. Jones, Paul R. Murdock, Tom Rupniak, Andy Honey, Kathryn R. Starr
Publikováno v:
Brain Research. 1152:215-227
Aberrant glutamatergic neurotransmission may underlie the pathogenesis of schizophrenia and metabotropic glutamate receptors (mGluRs) have been implicated in the disease. We have established the localization of the group III mGluR subtype, mGluR8, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1281b827d16319258572c1d22e0e1b25
https://doi.org/10.1016/j.brainres.2007.03.028
https://doi.org/10.1016/j.brainres.2007.03.028
Publikováno v:
Molecular and Cellular Neuroscience. 32:27-36
We previously showed that the mood stabilizers lithium, valproate (VPA), and carbamazepine (CBZ) have a common, inositol-reversible effect on the dynamic behavior of sensory neurons, suggesting that they all inhibit phosphoinositide (PIns) synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efad5697a2497778ae3dadbe07d35e5e
https://doi.org/10.1016/j.mcn.2006.01.015
https://doi.org/10.1016/j.mcn.2006.01.015
Autor:
Peter R. Maycox, Mark O. Cunningham, Steven J. Middleton, Martin G. Gillies, Jillian Hunt, Miles A. Whittington, Ceri H. Davies, Fiona E. N. LeBeau, Claudia Racca
Publikováno v:
The Journal of Neuroscience. 26:2767-2776
Psychiatric illnesses, particularly schizophrenia, are associated with disrupted markers for interneuronal function and interneuron-mediated brain rhythms such as gamma frequency oscillations. Here we investigate a possible link between these two obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44335f660b7cd981ed5015155651b7a3
https://doi.org/10.1523/jneurosci.5054-05.2006
https://doi.org/10.1523/jneurosci.5054-05.2006
Autor:
Peter R. Maycox, Lee A. Dawson, Claire S. Shilliam, Panida Winter, Claire Roberts, Zoe A. Hughes, Christopher J. Langmead
Publikováno v:
Neurochemical Research. 30:371-377
LPA1 is a Gi-coupled seven transmembrane receptor with high affinity for the ligand lysophosphatidic acid. We have investigated the effect of targeted deletion at the lpa1 locus on evoked release of amino acids from hippocampal slices, using in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01024f0f11290d3c0280344e6f0837f
https://doi.org/10.1007/s11064-005-2611-6
https://doi.org/10.1007/s11064-005-2611-6
Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons
Publikováno v:
Bipolar Disorders. 7:33-41
Objectives: The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6d05e877d804196054ffb726a444b6
https://doi.org/10.1111/j.1399-5618.2004.00164.x
https://doi.org/10.1111/j.1399-5618.2004.00164.x
Autor:
A. J. Hunter, Jane E. Cluderay, J. Latcham, Christian Heidbreder, Pippa L Pugh, Jon T. Brown, Charlie Reavill, Lee A. Dawson, Ceri H. Davies, Evelyn Grau, Susan J. Pickering, G Brown, Claire S. Shilliam, Barry Crook, A Howarth, Panida Hemmati, Zoe A. Hughes, Derek C. Rogers, Guillaume J. Hervieu, Stephen M. Harrison, Peter R. Maycox
Publikováno v:
Molecular and Cellular Neuroscience. 24:1170-1179
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA1 is a Gi-coupled seven transmembrane r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f5ca71824413304196e63bb4298e03
https://doi.org/10.1016/j.mcn.2003.09.001
https://doi.org/10.1016/j.mcn.2003.09.001