Výsledky vyhledávání - "Peter R. Holden"

Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression

Autor: Peter R. Holden, Ruth A. Roberts, A. Nigel Brooks, Neil H. James, Ian Kimber, William D. Pennie

Publikováno v: Journal of Biochemical and Molecular Toxicology. 14:283-290

Hepatotoxicants can elicit liver damage by various mechanisms that can result in cell necrosis and death. The changes induced by these compounds can vary from gross alterations in DNA repair mechanisms, protein synthesis, and apoptosis, to more discr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3941afc1d1421d44e67d8284b4de371
https://doi.org/10.1002/1099-0461(2000)14:5<283::aid-jbt7>3.0.co

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Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis

Autor: Brindle Rd, Neil H. James, Jason H. Gill, Jonathan Tugwood, M Rolfe, S.C. Hasmall, Nicola J. Woodyatt, Neil Macdonald, Ruth A. Roberts, Peter R. Holden

Publikováno v: Toxicology Letters. :91-96

Peroxisome proliferators (PPs) are a class of non-genotoxic rodent hepatocarcinogens that act by perturbing liver growth regulation. We have demonstrated previously that PPs suppress both spontaneous rat hepatocyte apoptosis and that induced by exoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f7d0fac65f97364398be5cd0a5e28
https://doi.org/10.1016/s0378-4274(98)00291-4

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A peroxisome proliferator-activated receptor-alpha (PPARα) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARα: implications for species differences in responses to peroxisome proliferators

Autor: Peter R. Holden, Neil H. James, Jonathan Tugwood, Ruth A. Roberts, Rebecca A. Prince

Publikováno v: Archives of Toxicology. 72:169-177

The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eccffee946943de2ee281428f6d9b5a
https://doi.org/10.1007/s002040050483

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Variation in the growth and biosynthetic activity of cloned cell cultures of Capsicum frutescens and their response to an exogenously supplied elicitor

Autor: Michael M. Yeoman, Peter R. Holden

Publikováno v: Plant Cell, Tissue and Organ Culture. 38:31-37

Twenty clones established from single cells of a suspension culture of Capsicum frutescens were maintained as callus and in suspension over a sixteen week culture period. These clones exhibited marked differences in growth, chlorophyll and chloroform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f04a3e7f73ce72bb74faf428bcf8951
https://doi.org/10.1007/bf00034440

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Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha

Autor: Douglas A. West, Peter R. Holden, Ruth A. Roberts, N.J Woodyatt, Neil Macdonald, Neil H. James, Susan C. Hasmall, D Whitcome, Kevin G. Lambe

Publikováno v: Toxicology letters.

Peroxisome proliferators (PPs) are nongenotoxic rodent hepatocarcinogens that cause liver enlargement and hepatocarcinogenesis associated with peroxisome proliferation, induction of hepatocyte DNA synthesis and suppression of apoptosis. Acyl CoA oxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad479f82a91d50cb343e764dce18e02
https://pubmed.ncbi.nlm.nih.gov/10720712

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Evidence for a Wolbachia symbiont in Drosophila melanogaster

Autor: Peter B. Jones, John F. Y. Brookfield, Peter R. Holden

Publikováno v: Genetical research. 62(1)

SummaryThe bacterial cell division gene,ftsZ, was used as a specific probe to show the presence of a symbiotic bacterium in two wild type strains ofDrosophila melanogaster. Under stringent hybridization conditions we have shown that the bacterium is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e94281c660e997ef146966c800e3a1
https://pubmed.ncbi.nlm.nih.gov/7691685

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Cloning and characterization of an ftsZ homologue from a bacterial symbiont of Drosophila melanogaster

Autor: John F. Y. Brookfield, Peter R. Holden, Peter B. Jones

Publikováno v: Moleculargeneral genetics : MGG. 240(2)

A 1194 bp open reading frame that codes for a 398 amino acid peptide was cloned from a lambda gt11 library of Drosophila melanogaster genomic DNA. The predicted peptide sequence is very similar to three previously characterized protein sequences that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1671f297a00304b704462bf044e77191
https://pubmed.ncbi.nlm.nih.gov/7689140

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