Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Peter R. Flatt"'
Autor:
Ananyaa Sridhar, Dawood Khan, Jessie A. Elliott, Violetta Naughton, Peter R. Flatt, Nigel Irwin, Charlotte R. Moffett
Publikováno v:
PLoS ONE, Vol 18, Iss 5 (2023)
Roux-en-Y gastric-bypass (RYGB) induced alterations in intestinal morphology and gut-cell hormone expression profile in the bypassed biliopancreatic-limb (BPL) versus the alimentary-limbs (AL) are poorly characterised. This pilot study has therefore
Externí odkaz:
https://doaj.org/article/5e28232ae80f46428d1743b6b07c8540
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
In folklore, Heritiera fomes (H. fomes) has been extensively used in treatment of various ailments such as diabetes, cardiac and hepatic disorders. The present study aimed to elucidate the antidiabetic actions of hot water extract of H. fomes (HWHF),
Externí odkaz:
https://doaj.org/article/22ae5a85ea8244be951077b5991f979c
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/d3219a927e2c4b1ba590b7fb88c8644b
Autor:
Dawood Khan, Opeolu O. Ojo, Orla RM Woodward, Jo Edward Lewis, Ananyaa Sridhar, Fiona M. Gribble, Frank Reimann, Peter R. Flatt, R. Charlotte Moffett
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1736 (2022)
Substantial evidence suggests crosstalk between reproductive and gut-axis but mechanisms linking metabolism and reproduction are still unclear. The present study evaluated the possible role of glucose-dependent-insulinotropic-polypeptide (GIP) and gl
Externí odkaz:
https://doaj.org/article/961674cc46fe46c19f2d2d8f7320ae5b
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Combined activation of GLP-1 and CCK1 receptors has potential to synergistically augment the appetite-suppressive and glucose homeostatic actions of the individual parent peptides. In the current study, pancreatic beta-cell benefits of combined GLP-1
Externí odkaz:
https://doaj.org/article/b02a839e593e45f6b44ad783e6dc51a0
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Initially discovered as an impurity in insulin preparations, our understanding of the hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With description of the precursor proglucagon, we now appreciate that glucagon was jus
Externí odkaz:
https://doaj.org/article/d0a5795b66e245ce963d4e2a4e609ce0
Autor:
Ryan A. Lafferty, Neil Tanday, R. Charlotte Moffett, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Nigel Irwin
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study, streptozotocin (STZ) diab
Externí odkaz:
https://doaj.org/article/ff3f9ed79ae042faab83503d27504daa
Publikováno v:
Plants, Vol 10, Iss 6, p 1190 (2021)
Acacia arabica is used traditionally to treat a variety of ailments, including diabetes. This study elucidated the antidiabetic actions of A. arabica bark together with the isolation of bioactive molecules. Insulin secretion and signal transduction w
Externí odkaz:
https://doaj.org/article/8b0e0f6f1977490a871517b366105e95
Autor:
Sity Aishah Mansur, Aleksandra Mieczkowska, Peter R. Flatt, Daniel Chappard, Nigel Irwin, Guillaume Mabilleau
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Type 2 diabetes mellitus (T2DM) has recently been recognized as a significant risk factor for bone fragility. Careful investigations of bone mechanical properties in human studies suggested possible alterations of bone composition, although this axis
Externí odkaz:
https://doaj.org/article/af6d189c8ee24d978777e4e54def2288
Publikováno v:
Plants, Vol 9, Iss 10, p 1348 (2020)
Annona squamosa is generally referred to as a ‘custard apple’. Antidiabetic actions of hot water extract of Annona squamosa (HWAS) leaves together with isolation of active insulinotropic compounds were studied. Insulin release, membrane potential
Externí odkaz:
https://doaj.org/article/5c455e244ba041abae142de6ae72d6f0