Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Peter R. Elliott"'
Autor:
William Connell, Lani Prideaux, Rupert W. Leong, Paul V. Desmond, Efrosinia O. Krejany, Finlay A. Macrae, Jane M. Andrews, Ian C. Lawrance, Warwick Selby, Richard B. Gearry, Alexandra Gorelik, Peter A. Bampton, Michael J. Johnston, Michael A. Kamm, Timothy H. Florin, Sally Bell, Kathryn J. Ritchie, H.S. Debinski, Peter R. Elliott, Danny Liew, P. De Cruz, Rodney Woods, Peter R. Gibson, Simon Jakobovits, I.J. Kronborg, Stephanie Brown, Graham L. Radford-Smith, Amy L. Hamilton
Publikováno v:
Alimentary Pharmacology & Therapeutics. 42:867-879
Background Crohn's disease recurs in the majority of patients after intestinal resection. Aim To compare the relative efficacy of thiopurines and anti‐TNF therapy in patients at high risk of disease recurrence. Methods As part of a larger study com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6ebd28d2c05f614068c017598d68c9
https://doi.org/10.1111/apt.13353
https://doi.org/10.1111/apt.13353
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 18:670-674
Patients with alpha1-antitrypsin (alpha1-AT) deficiency are at risk of developing early-onset panlobular basal emphysema, which has been attributed to uncontrolled proteolytic activity within the lung. Severe genetic deficiency of alpha1-AT is most c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e275f75c3c0c36d9cd5aa638578809fb
https://doi.org/10.1165/ajrcmb.18.5.3065
https://doi.org/10.1165/ajrcmb.18.5.3065
Publikováno v:
Nature Structural & Molecular Biology. 3:676-681
The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dd68af7b887ca03e1d91aad07f136c
https://doi.org/10.1038/nsb0896-676
https://doi.org/10.1038/nsb0896-676
Autor:
David A. Lomas, Robin W. Carrell, Diane W. Cox, James C. Whisstock, Richard C. Foreman, John T. Finch, Peter R. Elliott, Sanjiv K. Sidhar
Publikováno v:
Journal of Biological Chemistry. 270:16864-16870
The Z (Glu342-->Lys) and Siiyama (Ser53-->Phe) deficiency variants of alpha 1-antitrypsin result in the retention of protein in the endoplasmic reticulum of the hepatocyte by loop-sheet polymerization in which the reactive center loop of one molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::003c9d1296e4fa399e1faf349093cac9
https://doi.org/10.1074/jbc.270.28.16864
https://doi.org/10.1074/jbc.270.28.16864
Publikováno v:
Journal of Biological Chemistry. 270:5282-5288
Members of the serine proteinase inhibitor or serpin superfamily have a common molecular architecture based on a dominant five-membered A beta-pleated sheet and a mobile reactive center loop. The reactive center loop has been shown to adopt a range o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0176f6b323bab84d1306c95ee080d28c
https://doi.org/10.1074/jbc.270.10.5282
https://doi.org/10.1074/jbc.270.10.5282
Autor:
Finlay A. Macrae, Amy L. Hamilton, H.S. Debinski, Michael A. Kamm, Peter R. Gibson, Richard B. Gearry, William Connell, Timothy H. Florin, Rodney Woods, Michael J. Johnston, Sally Bell, Steven J. Brown, Paul V. Desmond, Warwick Selby, Ian Kronborg, Peter A. Bampton, Rupert W. Leong, Alexandra Gorelik, Miles P. Sparrow, Jane M. Andrews, Peter R. Elliott, Peter De Cruz, Ian C. Lawrance, Kathryn J. Ritchie, Danny Liew, Graham L. Radford-Smith
Publikováno v:
Gastroenterology. 150:S72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed813eb28bf7cff32adcdd9f8ae31281
https://doi.org/10.1016/s0016-5085(16)30358-4
https://doi.org/10.1016/s0016-5085(16)30358-4
Autor:
T.H. Florin, Paul V. Desmond, Emily K Wright, G. Radford-Smith, Finlay A. Macrae, Kathryn J. Ritchie, Amy L. Hamilton, William Connell, P. Bampton, Lani Prideaux, Sally Bell, Alexandra Gorelik, Warwick Selby, P. De Cruz, Efrosinia O. Krejany, Andrew S. Day, Richard B. Gearry, Danny Liew, Russell Woods, Douglas Samuel, H.S. Debinski, I.C. Lawrance, Peter R. Elliott, Jane M. Andrews, S.J. Brown, M.J. Johnson, Michael A. Kamm, Peter R. Gibson, Simon Jakobovits, I.J. Kronborg, Rupert W. Leong
Publikováno v:
Journal of Crohn's and Colitis. 8:S56-S57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::646b33db535122082b3e86d93248fcd3
https://doi.org/10.1016/s1873-9946(14)60111-2
https://doi.org/10.1016/s1873-9946(14)60111-2
Publikováno v:
Journal of Gastroenterology and Hepatology. 16:940-942
A case is described of a middle-aged female who developed an aggressive form of biopsy-proven metastatic Crohn's disease involving the inguinal, perineal and submammary areas. Her condition had been unresponsive to topical and systemic corticosteroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eec84b9cf29028b88c972b87c0103a2
https://doi.org/10.1046/j.1440-1746.2001.02439.x
https://doi.org/10.1046/j.1440-1746.2001.02439.x
Autor:
Michael A. Kamm, Amy L. Hamilton, Timothy H. Florin, H.S. Debinski, Steven J. Brown, Paul V. Desmond, Ian C. Lawrance, Ian Kronborg, Sharat Singh, Lani Prideaux, Graham L. Radford-Smith, Jane M. Andrews, Fabiyola Selvaraj, Kathryn J. Ritchie, Fred Princen, Danny Liew, Peter A. Bampton, William Connell, Peter R. Elliott, Richard B. Gearry, Douglas Samuel, Peter De Cruz, Emily K Wright, Efrosinia O. Krejany, Warwick Selby, Rodney Woods, Sally Bell, Alexandra Gorelik, Peter R. Gibson, Simon Jakobovits, Michael J. Johnston, Finlay A. Macrae
Publikováno v:
Gastroenterology. 148:S-849
remission at 3 months did not then undergo colectomy, yet 3/6 (50%) not in remission did (p=0.07). Bivariate comparisons for primary and secondary endpoints are tabulated below. Also, ROC analysis showed that the area under curve (AUC) of consecutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de7c700540a5c0e72ba535cefcaa0a2b
https://doi.org/10.1016/s0016-5085(15)32877-8
https://doi.org/10.1016/s0016-5085(15)32877-8
Autor:
William Connell, Finlay A. Macrae, Michael J. Johnston, Sally Bell, Rupert W. Leong, Fred Princen, Steven J. Brown, Peter A. Bampton, Sharat Singh, Miles P. Sparrow, H.S. Debinski, Jane M. Andrews, Peter R. Elliott, Peter De Cruz, Lani Prideaux, Warwick Selby, Richard B. Gearry, Efrosinia O. Krejany, Ian C. Lawrance, Danny Liew, Amy L. Hamilton, Alexandra Gorelik, Kathryn J. Ritchie, Michael A. Kamm, Peter R. Gibson, Timothy H. Florin, Paul V. Desmond, Emily K Wright, Ian Kronborg, Fabiyola Selvaraj, Rodney Woods, Graham L. Radford-Smith
Publikováno v:
Gastroenterology. 148:S-238
tions of IBD, i.e. flare or surgery occurring within 1 to 4 months of US, was calculated. Endoscopic and MRE findings were categorized for each bowel segment and the agreement between US and other techniques was considered only if the agreement on pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a17d1e94e9280a9b05c78d4f05fc73
https://doi.org/10.1016/s0016-5085(15)30783-6
https://doi.org/10.1016/s0016-5085(15)30783-6