Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Peter R W Gowler"'
Autor:
Peter R W Gowler, Paul I Mapp, James J Burston, Mohsen Shahtaheri, David A Walsh, Victoria Chapman
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur
Externí odkaz:
https://doaj.org/article/8d13051dad184535946f9d1a321775e3
Autor:
Peter R. W. Gowler, James Turnbull, Mohsen Shahtaheri, David A. Walsh, David A. Barrett, Victoria Chapman
Publikováno v:
European Journal of Pain. 26:2213-2226
Synovial inflammation has known contributions to chronic osteoarthritis (OA) pain, but the potential role in transitions from early to late stages of OA pain is unclear.The slowly progressing surgical destabilization of the medial meniscus (DMM) muri
Autor:
Peter R W Gowler, Stephen G. Woodhams, Victoria Chapman, Amanda Lillywhite, Sara Vieira Gonçalves, Gareth J. Hathway, Li Li, David Watson, David A. Walsh, Meritxell Canals, James J. Burston
Publikováno v:
Pain Reports
PAIN Reports, Vol 6, Iss 4, p e956 (2021)
PAIN Reports, Vol 6, Iss 4, p e956 (2021)
Supplemental Digital Content is Available in the Text. Comorbid anxiety and osteoarthritis pain is associated with increased opioid intake. Our translational model identifies reduced opioid analgesia and endogenous opioid dysfunction as potential mec
Autor:
Gareth Hathway, David A. Walsh, Amanda Lillywhite, Li Li, Meritxell Canals, Stephen George Woodhams, David Watson, James J. Burston, Victoria Chapman, Peter R W Gowler
Chronic pain states such as osteoarthritis (OA) are often associated with negative affect, including anxiety and depression. This is, in turn, associated with greater opioid analgesic use, potentially contributing to current and future opioid crises.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dbbf51df6534c80ee9d314702561cd
https://doi.org/10.1101/2020.04.24.057570
https://doi.org/10.1101/2020.04.24.057570
Autor:
Victoria Chapman, Petros Pousinis, Catherine A. Ortori, Dave Barrett, James J. Burston, Peter R W Gowler
Publikováno v:
Metabolomics
Introduction Osteoarthritis (OA) is the most common form of joint disease, causing pain and disability. Previous studies have demonstrated the role of lipid mediators in OA pathogenesis. Objectives To explore potential alterations in the plasma lipid
Autor:
Mohsen Shahtaheri, Victoria Chapman, Tony Kelly, Cindy B. McReynolds, David A. Walsh, Hammock D. Bruce, Ana M. Valdes, David A. Barrett, Yang Jun, James Turnbull, Michael Doherty, Rakesh Roshan Jha, Peter R W Gowler, Gwen Sascha Fernandes, Sameer Gohir, Weiya Zhang
Publikováno v:
Arthritis Rheumatol
Arthritis & rheumatology (Hoboken, N.J.), vol 74, iss 4
Arthritis & rheumatology (Hoboken, N.J.), vol 74, iss 4
Objective: Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) a
Autor:
David A. Walsh, Victoria Chapman, Rie Suzuki, Andrew J. Bennett, Li Li, Peter R W Gowler, Stephen G. Woodhams
Publikováno v:
Pain. 161(1)
Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also
Publikováno v:
Pain. 160(11)
Spinal hyperexcitability is a key event in the development of persistent pain, and arises partly from alterations in the number and localization of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptors. However, determini
Autor:
David A. Walsh, Paul I. Mapp, Victoria Chapman, Mohsen Shahtaheri, James J. Burston, Peter R W Gowler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
PLoS ONE, Vol 15, Iss 9, p e0239663 (2020)
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining sur
Autor:
Lilian N, Nwosu, Peter R W, Gowler, James J, Burston, Biljana, Rizoska, Karin, Tunblad, Erik, Lindström, Urszula, Grabowska, Li, Li, Dan F, McWilliams, David A, Walsh, Victoria, Chapman
Publikováno v:
Pain Reports
Supplemental Digital Content is Available in the Text.
Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of ca
Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of ca