Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Peter R Shepherd"'
Autor:
Christopher Puli'uvea, Tracey Immanuel, Taryn N. Green, Peter Tsai, Peter R. Shepherd, Maggie L. Kalev-Zylinska
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Objectives: This study aimed to compile bioinformatic and experimental information for JAK2 missense variants previously reported in myeloproliferative neoplasms (MPN) and determine if germline JAK2-I724T, recently found to be common in New Zealand P
Externí odkaz:
https://doaj.org/article/ce5b4c33076141b4ba8b6008985068fb
Autor:
Katrin Höland, Danielle Boller, Christian Hagel, Silvia Dolski, András Treszl, Olivier E Pardo, Paulina Cwiek, Fabiana Salm, Zaira Leni, Peter R Shepherd, Beata Styp-Rekowska, Valentin Djonov, André O von Bueren, Karl Frei, Alexandre Arcaro
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94132 (2014)
The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of target
Externí odkaz:
https://doaj.org/article/cd066ec9eb11427fb22bc81c1f4b6bc9
Autor:
Christina M Buchanan, James M J Dickson, Woo-Jeong Lee, Mark A Guthridge, Jackie D Kendall, Peter R Shepherd
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71337 (2013)
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF
Externí odkaz:
https://doaj.org/article/74058d667bd6498ab44f3854baf56a0d
Autor:
Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge
Publikováno v:
PLoS Biology, Vol 11, Iss 3, p e1001515 (2013)
The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in cancer. However, in contrast to canonical lipid-kinase functions, the role of PI3K protein kin
Externí odkaz:
https://doaj.org/article/6f994d55521847ca88fc793137e8fae9
Autor:
Janice B B Lam, Kim H M Chow, Aimin Xu, Karen S L Lam, Jing Liu, Nai-Sum Wong, Randall T Moon, Peter R Shepherd, Garth J S Cooper, Yu Wang
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4968 (2009)
Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency
Externí odkaz:
https://doaj.org/article/03f22a636964446e86d1d3bce8de7668
Autor:
Stewart W. C. Masson, Waruni C. Dissanayake, Sophie C. Broome, Christopher P. Hedges, Wouter M. Peeters, Martin Gram, David S. Rowlands, Peter R. Shepherd, Troy L. Merry
Publikováno v:
Physiological Reports, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract A central characteristic of insulin resistance is the impaired ability for insulin to stimulate glucose uptake into skeletal muscle. While insulin resistance can occur distal to the canonical insulin receptor‐PI3k‐Akt signaling pathway,
Externí odkaz:
https://doaj.org/article/0f3992d53ffb40488d95e17febf0a71a
Autor:
Rebecca Brandon, Yannan Jiang, Rui Qian Yeu, Ry Tweedie-Cullen, Kate Smallman, Glenn Doherty, Kerry A. Macaskill-Smith, Rebekah J. Doran, Penny Clark, Allan Moffitt, Troy Merry, Norma Nehren, Frances King, Jennie Harré Hindmarsh, Megan Patricia Leask, Tony R. Merriman, Brandon Orr-Walker, Peter R. Shepherd, Ryan Paul, Rinki Murphy
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
BackgroundUnderstanding which group of patients with type 2 diabetes will have the most glucose lowering response to certain medications (which target different aspects of glucose metabolism) is the first step in precision medicine.AimsWe hypothesize
Externí odkaz:
https://doaj.org/article/cffdbcc133504c5d9b4a6129c12786b9
Autor:
Kate Lee, Sanaz Vakili, Hannah J. Burden, Shannon Adams, Greg C. Smith, Braydon Kulatea, Morag Wright-McNaughton, Danielle Sword, Conor Watene-O’Sullivan, Robert D. Atiola, Ryan G. Paul, Lindsay D. Plank, Prasanna Kallingappa, Frances King, Phillip Wilcox, Tony R. Merriman, Jeremy D. Krebs, Rosemary M. Hall, Rinki Murphy, Troy L. Merry, Peter R. Shepherd
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101464- (2022)
Objective: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations.
Externí odkaz:
https://doaj.org/article/b85516b8e4994aafa7c1d2ec41065edb
Autor:
AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Jack U. Flanagan, Antony Braithwaite, Peter R. Shepherd, Cristin G. Print, Ming-Wei Wang, Annette Lasham
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 997-1007 (2019)
We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transc
Externí odkaz:
https://doaj.org/article/566f053049e54cc8b1fc43c2695257b5
Autor:
Peter R. Shepherd, Sanjeev Deva, Christina M. Buchanan, Jen-Hsing Shih, Qian Wang, Sharada Kolekar, Khanh B. Tran
Supplementary Data from Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd1c5153adf11ba858b350a6f9144a
https://doi.org/10.1158/1535-7163.22523467
https://doi.org/10.1158/1535-7163.22523467
