Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Peter R Shepherd"'
Autor:
Christopher Puli'uvea, Tracey Immanuel, Taryn N. Green, Peter Tsai, Peter R. Shepherd, Maggie L. Kalev-Zylinska
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Objectives: This study aimed to compile bioinformatic and experimental information for JAK2 missense variants previously reported in myeloproliferative neoplasms (MPN) and determine if germline JAK2-I724T, recently found to be common in New Zealand P
Externí odkaz:
https://doaj.org/article/ce5b4c33076141b4ba8b6008985068fb
Autor:
Stewart W. C. Masson, Waruni C. Dissanayake, Sophie C. Broome, Christopher P. Hedges, Wouter M. Peeters, Martin Gram, David S. Rowlands, Peter R. Shepherd, Troy L. Merry
Publikováno v:
Physiological Reports, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract A central characteristic of insulin resistance is the impaired ability for insulin to stimulate glucose uptake into skeletal muscle. While insulin resistance can occur distal to the canonical insulin receptor‐PI3k‐Akt signaling pathway,
Externí odkaz:
https://doaj.org/article/0f3992d53ffb40488d95e17febf0a71a
Autor:
Rebecca Brandon, Yannan Jiang, Rui Qian Yeu, Ry Tweedie-Cullen, Kate Smallman, Glenn Doherty, Kerry A. Macaskill-Smith, Rebekah J. Doran, Penny Clark, Allan Moffitt, Troy Merry, Norma Nehren, Frances King, Jennie Harré Hindmarsh, Megan Patricia Leask, Tony R. Merriman, Brandon Orr-Walker, Peter R. Shepherd, Ryan Paul, Rinki Murphy
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
BackgroundUnderstanding which group of patients with type 2 diabetes will have the most glucose lowering response to certain medications (which target different aspects of glucose metabolism) is the first step in precision medicine.AimsWe hypothesize
Externí odkaz:
https://doaj.org/article/cffdbcc133504c5d9b4a6129c12786b9
Autor:
Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy. Methods Given the high degree of genetic heterogeneity in melanoma, we sought to understand the breadth of variation in PI3K signalling in the la
Externí odkaz:
https://doaj.org/article/d29833ad5d6e40eeb218477ffd82bea6
Autor:
Kate Lee, Sanaz Vakili, Hannah J. Burden, Shannon Adams, Greg C. Smith, Braydon Kulatea, Morag Wright-McNaughton, Danielle Sword, Conor Watene-O’Sullivan, Robert D. Atiola, Ryan G. Paul, Lindsay D. Plank, Prasanna Kallingappa, Frances King, Phillip Wilcox, Tony R. Merriman, Jeremy D. Krebs, Rosemary M. Hall, Rinki Murphy, Troy L. Merry, Peter R. Shepherd
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101464- (2022)
Objective: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations.
Externí odkaz:
https://doaj.org/article/b85516b8e4994aafa7c1d2ec41065edb
Autor:
AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Jack U. Flanagan, Antony Braithwaite, Peter R. Shepherd, Cristin G. Print, Ming-Wei Wang, Annette Lasham
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 997-1007 (2019)
We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transc
Externí odkaz:
https://doaj.org/article/566f053049e54cc8b1fc43c2695257b5
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101091- (2020)
Objective: Skeletal muscle glucose disposal following a meal is mediated through insulin-stimulated movement of the GLUT4-containing vesicles to the cell surface. The highly conserved scaffold-protein β-catenin is an emerging regulator of vesicle tr
Externí odkaz:
https://doaj.org/article/be0ebe21d60544d69a6c52ffdbaef546
Publikováno v:
Biotechnology Reports, Vol 28, Iss , Pp e00533- (2020)
There is increasing demand for improved production and purification systems for biosimilar or biobetter humanised monoclonal antibodies and animal production systems offer one such possibile option. Cetuximab, also known as ‘Erbitux’, is a humani
Externí odkaz:
https://doaj.org/article/bbe42a31bf86402f8970a2c1427ecc9b
Publikováno v:
Cells, Vol 11, Iss 3, p 497 (2022)
The Arg457Gln missense variant in the CREBRF gene has previously been identified as driving excess body weight in Pacific/Oceanic populations. Intriguingly, Arg457Gln variant carriers also demonstrate paradoxical reductions in diabetes risk, indicati
Externí odkaz:
https://doaj.org/article/25733bb1f8c64fd898aa89174f9ffd5f
Autor:
Peter R. Shepherd, Sanjeev Deva, Christina M. Buchanan, Jen-Hsing Shih, Qian Wang, Sharada Kolekar, Khanh B. Tran
Supplementary Data from Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd1c5153adf11ba858b350a6f9144a
https://doi.org/10.1158/1535-7163.22523467
https://doi.org/10.1158/1535-7163.22523467
