Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Peter R Redden"'
Autor:
Leticia Toledo-Sherman, J. Estelle Foster, Neil Reid, and Andrew Pasternak, Jacek J. Slon-Usakiewicz, Peter R. Redden, William Ng, Eugen Deretey, Linda C. Liao, Marni D. Uger, Jin-Rui Dai
Publikováno v:
Journal of Medicinal Chemistry. 48:3221-3230
We have integrated two complementary methods, high-throughput virtual screening with a "high-content" wet screening technique based on frontal affinity chromatography with mass spectrometry detection (FAC-MS), for identification of hits against the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be6f89fb48b5189b86d46865f3ac16d
https://doi.org/10.1021/jm0492204
https://doi.org/10.1021/jm0492204
Autor:
Jin-Rui Dai, Leticia Toledo-Sherman, Peter R. Redden, J. Estelle Foster, Jacek J. Slon-Usakiewicz, and Andrew Pasternak, William Ng, Eugen Deretey, Neil Reid
Publikováno v:
Journal of Medicinal Chemistry. 47:5094-5100
FAC-MS offers a convenient method for measuring the relative binding strengths of ligands in a mixture and enables a rapid ranking and identification of ligands in the mixture as potential hits against immobilized targets. Using immobilized EphB2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d3c41fe779645c8ed09db1dea0d610
https://doi.org/10.1021/jm049733a
https://doi.org/10.1021/jm049733a
Autor:
Peter R Redden
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:337-353
Oestrogen or hormone replacement therapy (HRT) is an effective treatment for postmenopausal women in alleviating disorders associated with lower circulating levels of oestrogens such as hot flushes and osteoporosis. Unfortunately, long-term HRT is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb8c9491b1bd70bcd2108ab6f6791af
https://doi.org/10.1517/13543776.14.3.337
https://doi.org/10.1517/13543776.14.3.337
Autor:
Miklos Feher, Robert Dunn-Dufault, Jonathan M. Schmidt, Julie Mercure, Gilles B. Tremblay, Markus G. Peter, Peter R. Redden, Martine Pagé
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1389-1396
There is still a strong need for additional diversity and new chemical scaffolds to allow for the exploration of improved tissue selectivity and finding better selective estrogen receptor modulators (SERMs). Using a de novo design technology a diphen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a017398ad92388afab7acb86efc33
https://doi.org/10.1016/s0968-0896(02)00647-8
https://doi.org/10.1016/s0968-0896(02)00647-8
Autor:
Martine Pagé, Aida Kalbakji, Markus G. Peter, Jonathan M. Schmidt, Gilles B. Tremblay, Julie Mercure, Peter R. Redden, Miklos Feher, Robert Dunn-Dufault
Publikováno v:
Journal of Medicinal Chemistry. 46:1408-1418
Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7379b505242e2ac4dd96ec3242c119b
https://doi.org/10.1021/jm020536q
https://doi.org/10.1021/jm020536q
Publikováno v:
Ligand-Macromolecular Interactions in Drug Discovery ISBN: 9781607612438
Using frontal affinity chromatography coupled to mass spectrometry (FAC-MS) we have established a general stereoselective detection and screening method of intact racemates which can generate binding affinity information about the individual enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d240cb5a88ed597496cffa50d3246f
https://doi.org/10.1007/978-1-60761-244-5_14
https://doi.org/10.1007/978-1-60761-244-5_14
Autor:
Peter R. Redden, Yung-Sheng Huang
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 567:21-27
This report describes an improved separation and quantitation of lipid fractions in a total lipid extract by high-performance liquid chromatography using a modified solvent and gradient system delivered by dual pumps and incorporating a mass detector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cfa161a440a5f6ec14bdbe76a63193
https://doi.org/10.1016/0378-4347(91)80305-v
https://doi.org/10.1016/0378-4347(91)80305-v
Autor:
Neil Reid, Peter R. Redden, Jin-Rui Dai, Andrew Pasternak, Jacek J. Slon-Usakiewicz, William Ng
Publikováno v:
Journal of biomolecular screening. 12(2)
High-throughput screening (HTS) efforts to discover "hits" typically rely on the large-scale parallel screening of individual compounds with attempts to screen mixtures of compounds typically and, unfortunately, giving rise to false positives and fal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd6f38cf5d2ee9a251c3dcfcfd24320
https://pubmed.ncbi.nlm.nih.gov/17218664
https://pubmed.ncbi.nlm.nih.gov/17218664
Publikováno v:
Drug discovery today. 10(6)
The emergence of a relatively new technique resulting from a combination of frontal affinity chromatography coupled with MS detection (FAC-MS) has extended the capabilities of MS in drug discovery and development. Its application in a broad range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6851ac9c23a483322fefbd21ac02dc31
https://pubmed.ncbi.nlm.nih.gov/15808820
https://pubmed.ncbi.nlm.nih.gov/15808820
Autor:
Fupeng Ma, Miklos Feher, Michael A Plastina, Robert Dunn-Dufault, Peter R. Redden, Jonathan M. Schmidt, Sanjivanjit Bhal neé Basra, Gilles B. Tremblay
Publikováno v:
Bioorganicmedicinal chemistry. 13(5)
There is still a need for additional scaffolds to further explore tissue selectivity and improving efficacy of selective estrogen receptor modulators (SERMs). A series of hydroxyl substituted diphenylnaphthyl alkene ligands for the two estrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413ce0cf27d9bfc48025f492943de3de
https://pubmed.ncbi.nlm.nih.gov/15776560
https://pubmed.ncbi.nlm.nih.gov/15776560