Výsledky vyhledávání - "Peter R McDonald"

Akademický článek

Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation.

Autor: Kishore Polireddy, Ruochen Dong, Peter R McDonald, Tao Wang, Brendan Luke, Ping Chen, Melinda Broward, Anuradha Roy, Qi Chen

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164811 (2016)

Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute to chemoresistant tumors prone to metastasis and recurrence. Drug screening assays based on cytotoxicity cannot identify specific CSC inhibitors, because CSCs compri

Externí odkaz: https://doaj.org/article/20c4800de43943718f355b3e08ebed81

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Akademický článek

Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway.

Autor: Kai Connie Wu, Peter R McDonald, Jie Jerry Liu, Rathnam Chaguturu, Curtis D Klaassen

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e44686 (2012)

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes involved in antioxidant defense through binding to Antioxidant Response Elements (ARE) located in the promoter regions of thes

Externí odkaz: https://doaj.org/article/861bf9ee9cdf4ed4be4b8961a4a08638

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