Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Peter R Flatt"'
Publikováno v:
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 17 (2024)
Obesity and diabetes mellitus are prevalent metabolic disorders that have a detrimental impact on overall health. In this regard, there is now a clear link between these metabolic disorders and compromised bone health. Interestingly, both obesity and
Externí odkaz:
https://doaj.org/article/1101955a3b23497eb912bf8cd44725b0
Autor:
Ananyaa Sridhar, Dawood Khan, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Nigel Irwin, Charlotte R Moffett
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286062 (2023)
Roux-en-Y gastric-bypass (RYGB) induced alterations in intestinal morphology and gut-cell hormone expression profile in the bypassed biliopancreatic-limb (BPL) versus the alimentary-limbs (AL) are poorly characterised. This pilot study has therefore
Externí odkaz:
https://doaj.org/article/792751f6c6904d4587ea405c97f389e9
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0264632 (2022)
In folklore, Heritiera fomes (H. fomes) has been extensively used in treatment of various ailments such as diabetes, cardiac and hepatic disorders. The present study aimed to elucidate the antidiabetic actions of hot water extract of H. fomes (HWHF),
Externí odkaz:
https://doaj.org/article/ff4bffd7ac48414a832e44b22472c9ae
Autor:
Ananyaa Sridhar, Dawood Khan, Mahmoud Abdelaal, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Carel W Le Roux, Neil G Docherty, Charlotte R Moffett
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274788 (2022)
Modification of gut-islet secretions after Roux-En-Y gastric bypass (RYBG) surgery contributes to its metabolic and anti-diabetic benefits. However, there is limited knowledge on tissue-specific hormone distribution post-RYGB surgery and how this com
Externí odkaz:
https://doaj.org/article/3a023b714adc451694f8d1bcc25bef79
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261608 (2021)
Ac3IV (Ac-CYIQNCPRG-NH2) is an enzymatically stable vasopressin analogue that selectively activates Avpr1a (V1a) and Avpr1b (V1b) receptors. In the current study we have employed streptozotocin (STZ) diabetic transgenic Ins1Cre/+;Rosa26-eYFP and GluC
Externí odkaz:
https://doaj.org/article/75b3bdc019de4bc9b4e239e37829fc65
Publikováno v:
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 12 (2019)
Recent studies have identified a beneficial role for peptide tyrosine tyrosine (PYY) on pancreatic beta-cell function and survival. These effects are linked to the activation of neuropeptide Y1 receptors (NPYR1s) by PYY(1-36). However, PYY(1-36) is s
Externí odkaz:
https://doaj.org/article/2d37bb4febfc4bf1b78888c884717369
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202350 (2018)
Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This study investigated the antidiabetic effects of chronic administration of stable long actin
Externí odkaz:
https://doaj.org/article/4fbb1ad85286431f925df8bad32e9b41
Autor:
Christine M Martin, Vadivel Parthsarathy, Annie Hasib, Ming T Ng, Stephen McClean, Peter R Flatt, Victor A Gault, Nigel Irwin
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152818 (2016)
Xenin is a peptide that is co-secreted with the incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), from intestinal K-cells in response to feeding. Studies demonstrate that xenin has appetite suppressive effects and modulates glucos
Externí odkaz:
https://doaj.org/article/48c0049657e541ee9582ec5aa905974f
Autor:
Opeolu O Ojo, Dinesh K Srinivasan, Bosede O Owolabi, Srividya Vasu, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Wahab
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141549 (2015)
The frog skin host-defense peptide esculentin-2CHa (GFSSIFRGVA10KFASKGLGK D20LAKLGVDLVA30CKISKQC) displays antimicrobial, antitumor, and immunomodulatory properties. This study investigated the antidiabetic actions of the peptide and selected analogu
Externí odkaz:
https://doaj.org/article/94f88058155648b6a4b274e621e49018
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e101005 (2014)
Role of GLP-1 and GIP in beta cell compensatory responses to beta cell attack and insulin resistance were examined in C57BL/6 mice lacking functional receptors for GLP-1 and GIP. Mice were treated with multiple low dose streptozotocin or hydrocortiso
Externí odkaz:
https://doaj.org/article/cabce0eb2e8448fa81f33265603ddbc8