Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Peter R, Wilton"'
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008384 (2019)
Most current methods for detecting natural selection from DNA sequence data are limited in that they are either based on summary statistics or a composite likelihood, and as a consequence, do not make full use of the information available in DNA sequ
Externí odkaz:
https://doaj.org/article/f5954c0e8b3d41e999bce75b64129da6
Publikováno v:
International journal of legal medicine. 136(3)
Massively parallel sequencing (MPS) of mitochondrial (mt) DNA allows forensic laboratories to report heteroplasmy on a routine basis. Statistical approaches will be needed to determine the relative frequency of observing an mtDNA haplotype when inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::514e06155be5aacd86c728154bd00e18
https://pubmed.ncbi.nlm.nih.gov/35243529
https://pubmed.ncbi.nlm.nih.gov/35243529
Autor:
Peter R. Wilton, Arslan A. Zaidi, Ian M. Paul, Anton Nekrutenko, Marcia Shu-Wei Su, Barbara Arbeithuber, Kateryna D. Makova, Rasmus Nielsen, Kate Anthony
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 50
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 50
Significance Mitochondria frequently carry different DNA—a state called heteroplasmy. Heteroplasmic mutations can cause mitochondrial diseases and are involved in cancer and aging, but they are also common in healthy people. Here, we study heteropl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba1c07617bbcc72eca95bd76fd2842c
http://europepmc.org/articles/PMC6911200
http://europepmc.org/articles/PMC6911200
Autor:
Peter R. Wilton, Chuong B. Do, Adam Auton, J. Michael Macpherson, Joanna L. Mountain, Eric Durand, G. David Poznik
Ancestry deconvolution is the task of identifying the ancestral origins of chromosomal segments of admixed individuals. It has important applications, from mapping disease genes to identifying loci potentially under natural selection. However, most e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6266f004458b1d690fd73d0a76da89f
https://doi.org/10.1101/2021.01.19.427308
https://doi.org/10.1101/2021.01.19.427308
Non-additive polygenic models improve predictions of fitness traits in three eukaryote model species
To describe a living organism it is often said that “the whole is greater than the sum of its parts”. In genetics, we may also think that the effect of multiple mutations on an organism is greater than their additive individual effect, a phenomen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65cadd7c6c2db6ad5912c6e5c1d9c8b3
https://doi.org/10.1101/2020.07.14.194407
https://doi.org/10.1101/2020.07.14.194407
Autor:
Alison Barrett, Rasmus Nielsen, Ian M. Paul, Arslan A. Zaidi, Kateryna D. Makova, Barbara Arbeithuber, Peter R. Wilton
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 375, iss 1790
Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, vol 375, iss 1790
Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, vol 375, iss 1790
Heteroplasmy is the presence of variable mitochondrial DNA (mtDNA) within the same individual. The dynamics of heteroplasmy allele frequency among tissues of the human body is not well understood. Here, we measured allele frequency at heteroplasmic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1a7236a2efdc616c64c66fe4897c32
https://escholarship.org/uc/item/3sb1s5wk
https://escholarship.org/uc/item/3sb1s5wk
Autor:
Frank E. Rheindt, Kritika M. Garg, Balaji Chattopadhyay, Dewi M. Prawiradilaga, Peter R. Wilton
Publikováno v:
Molecular Phylogenetics and Evolution. 125:196-203
Cyclical periods of global cooling have been important drivers of biotic differentiation throughout the Quaternary. Ice age-induced sea level fluctuations can lead to changing patterns of land connections, both facilitating and disrupting gene flow.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387c639335e3a67171cf1491e24d16c7
https://doi.org/10.1016/j.ympev.2018.03.032
https://doi.org/10.1016/j.ympev.2018.03.032
Autor:
Frank E. Rheindt, Mochamad Indrawan, Nathaniel Ng, Peter R. Wilton, Kritika M. Garg, Dewi M. Prawiradilaga, Ywee Chieh Tay
Publikováno v:
Molecular Phylogenetics and Evolution. 114:353-366
The role of Pleistocene Ice Age in tropical diversification is poorly understood, especially in archipelagos, in which glaciation-induced sea level fluctuations may lead to complicated changes in land distribution. To assess how Pleistocene land brid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f67909303669091bb682cc2d25cc45e
https://doi.org/10.1016/j.ympev.2017.05.007
https://doi.org/10.1016/j.ympev.2017.05.007
Publikováno v:
Proceedings of the National Academy of Sciences. 113:7994-8001
Genetic variation among loci in the genomes of diploid biparental organisms is the result of mutation and genetic transmission through the genealogy, or population pedigree, of the species. We explore the consequences of this for patterns of variatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dfb331f32a9f84562f33eca5c7cefb
https://doi.org/10.1073/pnas.1601080113
https://doi.org/10.1073/pnas.1601080113
The mitochondria contained within the human body are genetically diverse. This type of variation, called heteroplasmy, is emerging as an important factor... The mitochondrion has recently emerged as an active player in myriad cellular processes. Addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83700be83a0eecaa704186d5b8e90c63
https://doi.org/10.1101/204479
https://doi.org/10.1101/204479