Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Peter R, Weigele"'
Autor:
Nathan P. Bullen, Cydney N. Johnson, Shelby E. Andersen, Garima Arya, Sonia R. Marotta, Yan-Jiun Lee, Peter R. Weigele, John C. Whitney, Breck A. Duerkop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to this crisis. A potential ther
Externí odkaz:
https://doaj.org/article/bb8b9b0015074f53b51e73e831da1801
Autor:
Ryan T. Fuchs, Jennifer L. Curcuru, Megumu Mabuchi, Audrey Noireterre, Peter R. Weigele, Zhiyi Sun, G. Brett Robb
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Two distinct Cas12a orthologs (Cme and Yme) from metagenomic sources are characterized. The enzymes are found to be thermotolerant and are compared to three mesophilic Cas12a enzymes (Lba, Fno and Asp).
Externí odkaz:
https://doaj.org/article/2f051ab7df9a4bb69aca89664afee82f
Autor:
Giedrius Gasiunas, Joshua K. Young, Tautvydas Karvelis, Darius Kazlauskas, Tomas Urbaitis, Monika Jasnauskaite, Mantvyda M. Grusyte, Sushmitha Paulraj, Po-Hao Wang, Zhenglin Hou, Shane K. Dooley, Mark Cigan, Clara Alarcon, N. Doane Chilcoat, Greta Bigelyte, Jennifer L. Curcuru, Megumu Mabuchi, Zhiyi Sun, Ryan T. Fuchs, Ezra Schildkraut, Peter R. Weigele, William E. Jack, G. Brett Robb, Česlovas Venclovas, Virginijus Siksnys
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A few bacterial Cas9 nucleases have been repurposed as genome editing tools. Here, the authors use bioinformatic and biochemical analyses to characterize 79 Cas9 proteins, revealing substantial functional diversity and thus expanding the available to
Externí odkaz:
https://doaj.org/article/eff8b92a7b8248269794dd870fd5600c
Autor:
Julie Zaworski, Colleen McClung, Cristian Ruse, Peter R Weigele, Roger W Hendrix, Ching-Chung Ko, Robert Edgar, Graham F Hatfull, Sherwood R Casjens, Elisabeth A Raleigh
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 1 (2021)
AbstractBacteriophage L, a P22-like phage of Salmonella entericaSalmonellacI–13–cII–immIantarcsieAsieBgtrABC
Externí odkaz:
https://doaj.org/article/22e6e5772b5b41c0b28b94278484500c
Autor:
Valérie de Crécy-lagard, Rocio Amorin de Hegedus, Cecilia Arighi, Jill Babor, Alex Bateman, Ian Blaby, Crysten Blaby-Haas, Alan J Bridge, Stephen K Burley, Stacey Cleveland, Lucy J Colwell, Ana Conesa, Christian Dallago, Antoine Danchin, Anita de Waard, Adam Deutschbauer, Raquel Dias, Yousong Ding, Gang Fang, Iddo Friedberg, John Gerlt, Joshua Goldford, Mark Gorelik, Benjamin M Gyori, Christopher Henry, Geoffrey Hutinet, Marshall Jaroch, Peter D Karp, Liudmyla Kondratova, Zhiyong Lu, Aron Marchler-Bauer, Maria-Jesus Martin, Claire McWhite, Gaurav D Moghe, Paul Monaghan, Anne Morgat, Christopher J Mungall, Darren A Natale, William C Nelson, Seán O’Donoghue, Christine Orengo, Katherine H O’Toole, Predrag Radivojac, Colbie Reed, Richard J Roberts, Dmitri Rodionov, Irina A Rodionova, Jeffrey D Rudolf, Lana Saleh, Gloria Sheynkman, Francoise Thibaud-Nissen, Paul D Thomas, Peter Uetz, David Vallenet, Erica Watson Carter, Peter R Weigele, Valerie Wood, Elisha M Wood-Charlson, Jin Xu
Valérie de Crécy-Lagard: et al.
Over the last 25 years, biology has entered the genomic era and is becoming a science of 'big data'. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by mo
Over the last 25 years, biology has entered the genomic era and is becoming a science of 'big data'. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bc0c0dc223190e4e256e36b3167003
Autor:
Ryan T, Fuchs, Jennifer L, Curcuru, Megumu, Mabuchi, Audrey, Noireterre, Peter R, Weigele, Zhiyi, Sun, G Brett, Robb
Publikováno v:
Communications biology. 5(1)
CRISPR-Cas12a proteins are RNA-guided endonucleases that cleave invading DNA containing target sequences adjacent to protospacer adjacent motifs (PAM). Cas12a orthologs have been repurposed for genome editing in non-native organisms by reprogramming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d52de699594fead92ca25de292f5a59c
https://pubmed.ncbi.nlm.nih.gov/35388146
https://pubmed.ncbi.nlm.nih.gov/35388146
Autor:
Yan-Jiun, Lee, Peter R, Weigele
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2198
Collectively, the dsDNA tailed bacteriophages (Caudovirales) contain the largest chemical diversity of naturally occurring deoxynucleotides in DNA observed to date. The continuing discovery of new modifications in phages suggest many more are waiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbfe5c16b5d28b9c30588c53f3609dc1
https://pubmed.ncbi.nlm.nih.gov/32822022
https://pubmed.ncbi.nlm.nih.gov/32822022