Esophageal cancer patients’ need for information and support in making a treatment decision between standard surgery and active surveillance

Autor: Merel Hermus, Berend J. van derWilk, Rebecca Chang, Jan Willem T. Dekker, Peter‐Paul L. O. Coene, Grard A. P. Nieuwenhuijzen, Camiel Rosman, Joos Heisterkamp, Henk H. Hartgrink, Liesbeth Timmermans, Bas P. L. Wijnhoven, Charlène J. van derZijden, Jan J. B. vanLanschot, Jan Busschbach, Sjoerd M. Lagarde, Leonieke W. Kranenburg

Publikováno v: Cancer Medicine, Vol 12, Iss 16, Pp 17266-17272 (2023)

Abstract Background This study explores patients’ need for information and support in deciding on esophageal cancer treatment, when experimental active surveillance and standard surgery are both feasible. Methods This psychological companion study

Externí odkaz: https://doaj.org/article/beb1a93477984302bbc08b7eb2b3b168

Monocyte response after colorectal surgery: A prospective cohort study

Autor: Pim P. Edomskis, Willem A. Dik, Cloë L. Sparreboom, Nicole M. A. Nagtzaam, Adrie van Oudenaren, Daniël P. V. Lambrichts, Yves Bayon, Noah N. N. van Dongen, Anand G. Menon, Eelco J. R. de Graaf, Peter Paul L. O. Coene, Johan F. Lange, Pieter J. M. Leenen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundTumor resection is the common approach in patients with colorectal malignancy. Profound insight into inflammatory changes that accompany the normal post-operative stress response will establish reference parameters useful for identification

Externí odkaz: https://doaj.org/article/94f1397f83834b83a976b0a1c3fa39dc

Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial

Autor: Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef, Manon C. W. Spaander, Roelf Valkema, Edwin S. van der Zaag, Ewout W. Steyerberg, J. Jan B. van Lanschot, on behalf of the SANO-study group

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Abstract Background Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection specimen. This provid

Externí odkaz: https://doaj.org/article/0805a4431d264f0ebffc6b2b562c7138

Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer

Autor: Karel C, Smit, Jeroen W G, Derksen, Geerard L O, Beets, Eric J Th, Belt, Maaike, Berbée, Peter Paul L O, Coene, Hester, van Cruijsen, Marjan A, Davidis, Jan Willem T, Dekker, Joyce M, van Dodewaard-de Jong, Annebeth W, Haringhuizen, Helgi H, Helgason, Mathijs P, Hendriks, Ronald, Hoekstra, Ignace H J T, de Hingh, Jan N M, IJzermans, Johan J B, Janssen, Joop L M, Konsten, Maartje, Los, Leonie J M, Mekenkamp, Peter, Nieboer, Koen C M J, Peeters, Natascha A J B, Peters, Hans J F M, Pruijt, Patricia, Quarles van Ufford-Mannesse, Ron C, Rietbroek, Anandi H W, Schiphorst, Arjan, Schouten van der Velden, Ruud W M, Schrauwen, Mark P S, Sie, Dirkje W, Sommeijer, Dirk J A, Sonneveld, Hein B A C, Stockmann, Marleen, Tent, Frederiek, Terheggen, Manuel L R, Tjin-A-Ton, Liselot, Valkenburg-van Iersel, Ankie M T, van der Velden, Wouter J, Vles, Theo, van Voorthuizen, Johannes A, Wegdam, Johannes H W, de Wilt, Miriam, Koopman, Anne M, May, On Behalf Of The Plcrc Study Group

Publikováno v: Cancers; Volume 14; Issue 4; Pages: 1001
Cancers, 14(4):1001. Multidisciplinary Digital Publishing Institute (MDPI)
PLCRC study group 2022, ' Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer ', Cancers, vol. 14, no. 4, 1001 . https://doi.org/10.3390/cancers14041001
Cancers, 14
Cancers, 14, 4

Regular physical activity (PA) is associated with improved overall survival (OS) in stage I–III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b4aa9d6becdee85e39e2432df7d126
http://www.scopus.com/inward/record.url?scp=85125380998&partnerID=8YFLogxK

588 Targeting GITR enhances human tumour-infiltrating T cell functionality in mismatch repair proficient primary colorectal carcinoma and liver metastases

Autor: Peter Paul L. O. Coene, Yannick Rakké, Michael Doukas, Susan ter Borg, Jaap Kwekkeboom, Valeska de Ruiter, Adriaan van Beek, Dirk J. Grünhagen, Maarten Vermaas, Dave Sprengers, Lucia Campos Carrascosa, Jan N. M. IJzermans, Erwin van der Harst, Cornelis Verhoef, Pascal G. Doornebosch

Publikováno v: Regular and young investigator award abstracts.

Background Immune checkpoint blockade (ICB; e.g. anti-PD-1/-CTLA-4) has been proven to be clinically effective in mismatch repair deficient (dMMR) colorectal carcinoma (CRC). Yet, the majority of patients carry mismatch repair proficient (pMMR) CRC,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bcb7a14efcd53c7dee4a8df062af0bd
https://doi.org/10.1136/jitc-2020-sitc2020.0588