Zobrazeno 1 - 10
of 587
pro vyhledávání: '"Peter Parham"'
Autor:
Emily E. Wroblewski, Lisbeth A. Guethlein, Aaron G. Anderson, Weimin Liu, Yingying Li, Sara E. Heisel, Andrew Jesse Connell, Jean-Bosco N. Ndjango, Paco Bertolani, John A. Hart, Terese B. Hart, Crickette M. Sanz, David B. Morgan, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn, Peter Parham
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
A variant of MHC class I is protective against severe malaria disease and enriched in affected African populations. Here, Wroblewski et al., characterise the consequences of malaria infection in wild bonobo populations showing that the presence of ma
Externí odkaz:
https://doaj.org/article/528a72be56a540989e1b30f98ac36d3f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human NK cells are usually defined as CD3-CD56+ lymphocytes. However, a CD56-CD16+ (CD56neg) lymphocyte population that displays NK-associated markers expands during chronic viral infections such as HIV-1 and HCV, and, to lesser extent, in herpesviru
Externí odkaz:
https://doaj.org/article/7f4bb42b45d54182a0651a4c534769ac
Autor:
Nolwenn Legrand, Perla Salameh, Maxime Jullien, Patrice Chevallier, Enora Ferron, Gaelle David, Marie-Claire Devilder, Catherine Willem, Ketevan Gendzekhadze, Peter Parham, Christelle Retière, Katia Gagne
Publikováno v:
Cancers, Vol 15, Iss 10, p 2754 (2023)
KIR3DL1 alleles are expressed at different levels on the natural killer (NK) cell surface. In particular, the non-expressed KIR3DL1*004 allele appears to be common in Caucasian populations. However, the overall distribution of non-expressed KIR3DL1 a
Externí odkaz:
https://doaj.org/article/810cea8da67d4a3a84dd6fcdd5f1fe38
Autor:
Oisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey, Francesco Colucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual
Externí odkaz:
https://doaj.org/article/686fd2691411467caa9337f1f7add0f8
Publikováno v:
PeerJ, Vol 9, p e12258 (2021)
Killer Immunoglobulin-like Receptors (KIR) comprise a diverse, highly polymorphic family of cell-surface glycoproteins that are principally expressed by Natural Killer (NK) cells. These innate immune lymphocytes fulfill vital functions in human repro
Externí odkaz:
https://doaj.org/article/0f97dca8a0bb4777a6e1068ed4bda8da
Autor:
Leonardo M. Amorim, Danillo G. Augusto, Neda Nemat-Gorgani, Gonzalo Montero-Martin, Wesley M. Marin, Hengameh Shams, Ravi Dandekar, Stacy Caillier, Peter Parham, Marcelo A. Fernández-Viña, Jorge R. Oksenberg, Paul J. Norman, Jill A. Hollenbach
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural variation and high sequence similarity among genes, imposing technical difficulties for analysis. We undertook the most comprehensive study to date of KIR geneti
Externí odkaz:
https://doaj.org/article/aa5a1107c343415581b1d8b8a30fec56
Autor:
Patricia T. Illing, Phillip Pymm, Nathan P. Croft, Hugo G. Hilton, Vladimir Jojic, Alex S. Han, Juan L. Mendoza, Nicole A. Mifsud, Nadine L. Dudek, James McCluskey, Peter Parham, Jamie Rossjohn, Julian P. Vivian, Anthony W. Purcell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA
Externí odkaz:
https://doaj.org/article/57210117d3c3489fa9dd810651f36182
Autor:
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell f
Externí odkaz:
https://doaj.org/article/8759d92b23c14ad39042c5176a30a02a
Autor:
Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, Zakia Djaoud, Lisbeth A. Guethlein, Jeroen H. Blokhuis, Jason L. Pugh, Ana Goyos, Amir Horowitz, Rico Buchli, Ken W. Jackson, Wilfred Bardet, David A. Bushnell, Philip J. Robinson, Juan L. Mendoza, Michael E. Birnbaum, Morten Nielsen, K. Christopher Garcia, William H. Hildebrand, Peter Parham
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1394-1405 (2017)
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-co
Externí odkaz:
https://doaj.org/article/80996e0dab9f4ff09d46ee3a014674f3
Autor:
Matteo Fumagalli, Stephane M Camus, Yoan Diekmann, Alice Burke, Marine D Camus, Paul J Norman, Agnel Joseph, Laurent Abi-Rached, Andrea Benazzo, Rita Rasteiro, Iain Mathieson, Maya Topf, Peter Parham, Mark G Thomas, Frances M Brodsky
Publikováno v:
eLife, Vol 8 (2019)
CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic analyses of the CHC22-encoding CLTCL1 gene, revealing independent gene l
Externí odkaz:
https://doaj.org/article/788427027f4d4457b906ca8b15739a62