Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Peter P.K. Ho"'
Autor:
Richard A. Hahn, Robert J. Boyd, William T. Jackson, Terry D. Lindstrom, Lee A. Phebus, Anthony T. Murphy, Alan Breau, Richard D. Towner, Yu Melvin Joseph, G. Donald Pollock, Phillip J. Ertel, Kenneth J. Ruterbories, Mitchell I. Steinberg, Peter P.K. Ho, Jefferson Ray Mccowan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1121-1126
We report a structurally novel series of quinazolines with in vivo antiarrhythmic and/or in vitro iron-dependent lipid peroxidation inhibitory activity. Two analogues, 7 and 12, were evaluated in a canine model of regional myocardial ischemia and rep
Autor:
Peter P.K. Ho, Lee A. Phebus, Barbara Bertsch, Paul J. Simpson, Kenneth J. Ruterbories, Terry D. Lindstrom, Jefferson Ray Mccowan, Yu Melvin Joseph, Jeffrey K. Smallwood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:59-62
A series of phenothiazine and phenoxazine analogs of nafazatrom were prepared and evaluated as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors (rabbit brain homogenate) in vitro. Nafazatrom and two representatives from the described s
Publikováno v:
Journal of Pharmacological Methods. 26:277-287
A quantitative method to assess relative potencies (IC 50 ) of 5-lipoxygenase (5-LO) enzyme inhibitors was established in antigen-induced contractions of tracheas isolated from actively sensitized guinea pigs (Schultz-Dale model). The relative potenc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:107-110
A series of phenoxazines was evaluated as in vitro inhibitors of 5-lipoxygenase (5-LO) and iron-dependent lipid peroxidation. A linear relationship (r2 = 0.91, n = 10) was found for the ester, hydroxamic acid and C-1 carboxylic acid representatives s
Publikováno v:
Life Sciences. 46:917-925
Anaphylactic shock was induced in actively sensitized guinea pigs by free inhalation of a high dose of ovalbumin (10 mg/ml) aerosol. Tibenelast (LY 186655), 5,6-diethoxybenzo (b)-thiophene-2-carboxylic acid, sodium salt, proved to be a potent orally
Publikováno v:
Agents and Actions. 34:100-102
LY221068, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxy phenyl]methylene]-3-(dimethylamino)-4-thiazolidinone, and the monomethylamino analog, LY269415, are anti-oxidants and potent inhibitors of iron dependent lipid peroxidation and 5-lipoxygenase enzyme.
Publikováno v:
Annals of the New York Academy of Sciences. 696:415-416
Publikováno v:
Stroke. 24(5)
In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of benefit when given after ischemia. Because postischemia administration is more clinically relevant, we evaluated the antioxidant LY231617 (2,6-bis(1,1
Publikováno v:
Stroke. 22(8)
Several feasible mechanisms have been proposed as sources of neuronal damage from ischemia and subsequent reperfusion. Included among these are oxidative damage caused by free radical production and lipid peroxidation and products derived from phosph
Autor:
Jill Ann Panetta, Phillips Michael Leroy, Don N. Benslay, Peter P.K. Ho, Richard D. Towner, James A. Clemens, Michael E. Roush
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b4eec010cb82f28f54bc8b214cb01a
https://doi.org/10.1016/b978-0-08-041749-3.50156-x
https://doi.org/10.1016/b978-0-08-041749-3.50156-x