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pro vyhledávání: '"Peter P. Pakstis"'
Autor:
Shirley L. Zhang, Nicholas F. Lahens, Zhifeng Yue, Denice M. Arnold, Peter P. Pakstis, Jessica E. Schwarz, Amita Sehgal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.
Externí odkaz:
https://doaj.org/article/a7136728c6604f689f9ba94c54ccf6b6
Autor:
Nicholas F. Lahens, Denice M. Arnold, Shirley L. Zhang, Amita Sehgal, Peter P. Pakstis, Zhifeng Yue, Jessica Schwarz
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The blood-brain barrier (BBB) is critical for neural function. We report here circadian regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with highest levels during the active phase and lowest during the resting p