Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Peter P. McCann"'
Autor:
Petek K. Chiang, Jacov Tal, B. P. Doctor, K. Pardhasaradhi, Peter P. McCann, G. C. Zeng, Richard K. Gordon
Publikováno v:
The FASEB Journal. 10:471-480
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be tak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0bfeeb8a6e89635833d98e284a7a4d
https://doi.org/10.1096/fasebj.10.4.8647346
https://doi.org/10.1096/fasebj.10.4.8647346
Autor:
Joanne Garofalo, Cyrus J. Bacchi, Donna Rattendi, Peter P. McCann, Nigel Yarlett, Maryann Ciminelli, Burt Goldberg
Publikováno v:
Biochemical Pharmacology. 46:471-481
The ornithine decarboxylase (ODC) inhibitor dl -α-difluoromethylornithine (DFMO) has emerged as a new treatment for West African sleeping sickness but is less effective against East African sleeping sickness. We examined uncloned clinical isolates o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::693b36dff6740a78a8e548ff1a0c2d75
https://doi.org/10.1016/0006-2952(93)90524-z
https://doi.org/10.1016/0006-2952(93)90524-z
Autor:
Jennifer A. Dumont, Albert Sjoerdsma, Edwards Michael L, Alan J. Bitonti, Peter P. McCann, Philippe Bey, D. M. Stemerick
Publikováno v:
ChemInform. 22
A series of novel tetraamines of the general formula RNH(CH2)xNH(CH2)yNH(CH2)xNHR was synthesized and examined for activity against growth of Plasmodium falciparum in vitro. Within the series, dibenzyl analogues (R = benzyl) were found to be the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6363fa3504d58f4966cbc7c525b4b9fe
https://doi.org/10.1002/chin.199138108
https://doi.org/10.1002/chin.199138108
Autor:
Anthony E. Pegg, Peter P. McCann
Publikováno v:
Pharmacology & Therapeutics. 56:359-377
The polyamine biosynthetic pathway has attracted much interest as a therapeutic target. Many studies have shown the potential value of inhibitors of the first enzyme in the biosynthetic pathway, ornithine decarboxylase, which forms putrescine. In ord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e2ce78fad5c83295bea5f518909b4b
https://doi.org/10.1016/0163-7258(92)90025-u
https://doi.org/10.1016/0163-7258(92)90025-u
Autor:
Doreen E. Cross-Doersen, Peter P. McCann, Alan J. Bitonti, Terry L. Bowlin, Kendra K. Schroeder, Paul S. Wright
Publikováno v:
Biochemical Pharmacology. 41:1855-1861
Adherence of Plasmodium falciparum-intected erythrocytes (IE) to the venular endothelium in brain and other organs is characteristic of cerebral malaria, an often fatal complication in infected individuals. It has been shown that cytoadherence may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0853ece305a428a3aa4a99fa75955562
https://doi.org/10.1016/0006-2952(91)90124-n
https://doi.org/10.1016/0006-2952(91)90124-n
Publikováno v:
Phytochemistry. 30:99-103
In pea seedlings, arginine decarboxylase (ADC) activity was found in the cotyledons, roots and epicotyls. At the detectability threshold of 0.08 pkat g−1 fresh wt, ornithine decarboxylase (ODC) activity was found only in the roots, while lysine dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43fe5a29b00dea05eb0bd7a8b0a65010
https://doi.org/10.1016/0031-9422(91)84106-3
https://doi.org/10.1016/0031-9422(91)84106-3
Publikováno v:
Phytochemistry. 30:105-108
Inhibition of arginine decarboxylase activity by ca 60–90% in leaves of intact oat seedlings and of Heliotropium indicum plants, treated with difluoromethylarginine alone or together with difluoromethylornithine for ca 13 days, had little effect on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a884192ad7ba2249d06bf9328f1e7ed6
https://doi.org/10.1016/0031-9422(91)84107-4
https://doi.org/10.1016/0031-9422(91)84107-4
Publikováno v:
Experimental Parasitology. 71:346-349
Description d'une methode de mesure de cytoadherence basee sur des tests radioactifs in vitro utilisant des cellules de melanome humain et des erythrocytes infectes par P. falciparum, marques par l'hypoxanthine-H 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f812d236ebdbc377946ff73a86abcfb4
https://doi.org/10.1016/0014-4894(90)90040-j
https://doi.org/10.1016/0014-4894(90)90040-j
Publikováno v:
Biochemical Journal. 269:35-40
Bis(benzyl)polyamine analogues (e.g. NN′-bis(3-[(phenylmethyl)amino]propyl)-1,8-diamino-octane [C6H5CH2NH-(CH2)3NH(CH2)8NH(CH2)3NHCH2C6H5]) have previously been shown to regulate polyamine biosynthesis and growth of rat hepatoma (HTC) cells. Satura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d46ea489433b480f7729cdbe0aad84
https://doi.org/10.1042/bj2690035
https://doi.org/10.1042/bj2690035
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:722-727
It was recently demonstrated that a bis(benzyl)polyamine analog (MDL 27695; N,N'-bis(3-[(phenylmethyl)amino]propyl)-1,7-diaminoheptane) possessed potent antimalarial activity in vitro and in vivo (A. J. Bitonti, J. A. Dumont, T. L. Bush, M. L. Edward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1024196fc837a9eeab34c57aa475822
https://doi.org/10.1128/aac.34.5.722
https://doi.org/10.1128/aac.34.5.722