Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Peter P, Nghiem"'
Autor:
J. William Deaver, Sara Mata López, Patrick J. Ryan, Peter P. Nghiem, Steven E. Riechman, James D. Fluckey
Publikováno v:
Sports Medicine and Health Science, Vol 2, Iss 4, Pp 195-201 (2020)
The process and regulation of cellular metabolism are extremely complex and accomplished through multiple signalling pathways that operate in parallel, and often experience significant overlap in upstream and downstream a signal transduction. Despite
Externí odkaz:
https://doaj.org/article/913aceee91aa41d4b18dc2cba3f6f18e
Autor:
Paul T Martin, Deborah A Zygmunt, Anna Ashbrook, Sonia Hamilton, Davin Packer, Sharla M Birch, Amanda K Bettis, Cynthia J Balog-Alvarez, Lee-Jae Guo, Peter P Nghiem, Joe N Kornegay
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248721 (2021)
We have examined the effects of intravenous (IV) delivery of rAAVrh74.MHCK7.GALGT2 in the golden retriever muscular dystrophy (GRMD) model of Duchenne Muscular Dystrophy (DMD). After baseline testing, GRMD dogs were treated at 3 months of age and rea
Externí odkaz:
https://doaj.org/article/8daea8ae30e441fc877a6ae566d3dfd6
Autor:
Sara Mata López, Cynthia Balog-Alvarez, Stanislav Vitha, Amanda K Bettis, Emily H Canessa, Joe N Kornegay, Peter P Nghiem
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228072 (2020)
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that abolish the expression of dystrophin protein. Dogs with the genetic homologue, golden retriever muscular dystrophy dog (GRMD), have a splice site mutation that leads to ski
Externí odkaz:
https://doaj.org/article/5d359478a6644a74a36775ec8ab4dde0
Autor:
Sara Mata López, Cynthia Balog-Alvarez, Stanislav Vitha, Amanda K Bettis, Emily H Canessa, Joe N Kornegay, Peter P Nghiem
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241430 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0228072.].
Externí odkaz:
https://doaj.org/article/b1443758b0054829b4f1522d684c93d4
Autor:
Jessica R Terrill, Basma A Al-Mshhdani, Marisa N Duong, Catherine D Wingate, Zahra Abbas, Angelo P Baustista, Amanda K Bettis, Cynthia J Balog-Alvarez, Joe N Kornegay, Peter P Nghiem, Miranda D Grounds, Peter G Arthur
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240317 (2020)
Duchenne muscular dystrophy (DMD) is a lethal, X-chromosome linked muscle-wasting disease affecting about 1 in 3500-6000 boys worldwide. Myofibre necrosis and subsequent loss of muscle mass are due to several molecular sequelae, such as inflammation
Externí odkaz:
https://doaj.org/article/eae05b71b57444cfbe0f2f0026f1357c
Autor:
Sara Mata López, James J. Hammond, Madison B. Rigsby, Cynthia J. Balog-Alvarez, Joe N. Kornegay, Peter P. Nghiem
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-6 (2018)
Abstract Background Boys with Duchenne muscular dystrophy (DMD) have DMD gene mutations, with associated loss of the dystrophin protein and progressive muscle degeneration and weakness. Corticosteroids and palliative support are currently the best tr
Externí odkaz:
https://doaj.org/article/eb783a37156645ac8356d2e5603c7c91
Autor:
Lee‐Jae Guo, Jonathan H. Soslow, Amanda K. Bettis, Peter P. Nghiem, Kevin J. Cummings, Mark W. Lenox, Matthew W. Miller, Joe N. Kornegay, Christopher F. Spurney
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019)
Background Duchenne muscular dystrophy (DMD) is an X‐linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is genetically homologous with
Externí odkaz:
https://doaj.org/article/21520871b58b4c7c9d2cda64abd81fc7
Autor:
Sharla M. Birch, Michael W. Lawlor, Thomas J. Conlon, Lee-Jae Guo, Julie M. Crudele, Eleanor C. Hawkins, Peter P. Nghiem, Mihye Ahn, Hui Meng, Margaret J. Beatka, Brittany A. Fickau, Juan C. Prieto, Martin A. Styner, Michael J. Struharik, Courtney Shanks, Kristy J. Brown, Diane Golebiowski, Amanda K. Bettis, Cynthia J. Balog-Alvarez, Nathalie Clement, Kirsten E. Coleman, Manuela Corti, Xiufang Pan, Stephen D. Hauschka, J. Patrick Gonzalez, Carl A. Morris, Joel S. Schneider, Dongsheng Duan, Jeffrey S. Chamberlain, Barry J. Byrne, Joe. N. Kornegay
Publikováno v:
Science translational medicine. 15(677)
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by the absence of dystrophin, a membrane-stabilizing protein encoded by the DMD gene. Although mouse models of DMD provide insight into the potential of a corrective the
Autor:
Patrick J. Ryan, J William Deaver, Peter P. Nghiem, Sara Mata López, James D. Fluckey, Steven E. Riechman
Publikováno v:
Sports Medicine and Health Science, Vol 2, Iss 4, Pp 195-201 (2020)
The process and regulation of cellular metabolism are extremely complex and accomplished through multiple signalling pathways that operate in parallel, and often experience significant overlap in upstream and downstream a signal transduction. Despite
Autor:
Cynthia J. Balog-Alvarez, Joe N. Kornegay, Sara Mata López, Kristy J. Brown, Peter P. Nghiem, Stanislav Vitha, Emily H. Canessa, Yetrib Hathout, Jessica F. Boehler, Amanda K. Bettis
Publikováno v:
Mammalian Genome. 31:95-109
The availability of an in vitro canine cell line would reduce the need for dogs for primary in vitro cell culture and reduce overall cost in pre-clinical studies. An immortalized canine muscle cell line, named Myok9, from primary myoblasts of a norma