Zobrazeno 1 - 10
of 843
pro vyhledávání: '"Peter P, Nawroth"'
Publikováno v:
Monitor Versorgungsforschung, Vol 2024, Iss 05, Pp 52-56 (2024)
Die Autoren einer Arbeit, die den möglichen Effekt verschiedener Steuermodelle bzw. eine gestaffelte Herstellerabgabe auf gezuckerte Getränke hochrechnete, kamen zu dem Schluss, dass solch eine Steuer in den Jahren 2023 bis 2043 einige Effekte in D
Externí odkaz:
https://doaj.org/article/19e6ed8074db43ca854d4cfbd4ba139e
Autor:
Sina Rhein, Riccardo Costalunga, Julica Inderhees, Tammo Gürtzgen, Teresa Christina Faupel, Zaib Shaheryar, Adriana Arrulo Pereira, Alaa Othman, Kimberly Begemann, Sonja Binder, Ines Stölting, Valentina Dorta, Peter P. Nawroth, Thomas Fleming, Konrad Oexle, Vincent Prevot, Ruben Nogueiras, Svenja Meyhöfer, Sebastian M. Meyhöfer, Markus Schwaninger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Complications of diabetes are often attributed to glucose and reactive dicarbonyl metabolites derived from glycolysis or gluconeogenesis, such as methylglyoxal. However, in the CNS, neurons and endothelial cells use lactate as energy source
Externí odkaz:
https://doaj.org/article/3794cebd4fc44846a1424fb0ce46d765
Autor:
Philip Harrer, Julica Inderhees, Chen Zhao, Barbara Schormair, Erik Tilch, Christian Gieger, Annette Peters, Olaf Jöhren, Thomas Fleming, Peter P. Nawroth, Klaus Berger, Marco Hermesdorf, Juliane Winkelmann, Markus Schwaninger, Konrad Oexle
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105007- (2024)
Summary: Background: The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic and genotypic association studies with phenome-wide and genome-wi
Externí odkaz:
https://doaj.org/article/c87523ca0c424d7f8f197fe4dbad99de
Autor:
Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. König, Georg Royl, Markus Schwaninger
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did not improve stroke ou
Externí odkaz:
https://doaj.org/article/059cd2a8279e4ad29ee5c62318e45b7c
Autor:
Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract Omega‐6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega‐6 fatty acids to an oxidative environment results in the generation of a highly
Externí odkaz:
https://doaj.org/article/d3e9abcfffc843caa8b54bf9e9a82f24
Autor:
Andreas Peter, Erwin Schleicher, Elisabeth Kliemank, Julia Szendroedi, Alfred Königsrainer, Hans-Ulrich Häring, Peter P. Nawroth, Thomas Fleming
Publikováno v:
Metabolites, Vol 14, Iss 4, p 209 (2024)
The underlying molecular mechanisms for the development of non-alcoholic fatty liver (NAFL) and its progression to advanced liver diseases remain elusive. Glyoxalase 1 (Glo1) loss, leading to elevated methylglyoxal (MG) and dicarbonyl stress, has bee
Externí odkaz:
https://doaj.org/article/5d61a43d3a3b448796428533b0b83130
Autor:
Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyp
Externí odkaz:
https://doaj.org/article/e0c24968fbe44886ac4eb5d91d955ed8
Autor:
Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, Chiara Simone Middel, Vanessa Erben, Hannes Ott, Tanja Poth, Thomas Fleming, Jakob Morgenstern, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102576- (2023)
Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to d-lactate via SD-Lactoylglutathione. Recent in vitro studies have suggested Glo2 as a regulator of glycolysis, but if Glo2 regulates glucose
Externí odkaz:
https://doaj.org/article/8ec9121e06394c43ad839a73926f3863
Autor:
David Philipp Wohlfart, Bowen Lou, Chiara Simone Middel, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Rüdiger Hell, Hans-Peter Hammes, Julia Szendrödi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102249- (2022)
Reactive carbonyl species (RCS) are spontaneously formed in the metabolism and modify and impair the function of DNA, proteins and lipids leading to several organ complications. In zebrafish, knockout of the RCS detoxifying enzymes glyoxalase 1 (Glo
Externí odkaz:
https://doaj.org/article/3d1cdcad30e44060993f91c00777083e
Autor:
Susanne Gaul, Khurrum Shahzad, Rebekka Medert, Ihsan Gadi, Christina Mäder, Dagmar Schumacher, Angela Wirth, Saira Ambreen, Sameen Fatima, Jes-Niels Boeckel, Hamzah Khawaja, Jan Haas, Maik Brune, Peter P. Nawroth, Berend Isermann, Ulrich Laufs, Marc Freichel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveAtherosclerosis, the main pathology underlying cardiovascular diseases is accelerated in diabetic patients. Genetic mouse models require breeding efforts which are time-consuming and costly. Our aim was to establish a new nongenetic model of
Externí odkaz:
https://doaj.org/article/56c5ef21b0ed4df3b798f8eedcf9f944