Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Peter O. Awinda"'
Autor:
Peter O. Awinda, Weikang Ma, Kyrah L. Turner, Jing Zhao, Henry Gong, Mindy S. Thompson, Kenneth S. Campbell, Thomas C. Irving, Bertrand C. W. Tanner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15084 (2022)
Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and Mg2+-adenosine diphosphate (ADP), and release of these hydrolysis products drives chemo-mechan
Externí odkaz:
https://doaj.org/article/4b3d2da720e0436f80c18278c270a1ce
Autor:
Hannah C. Pulcastro, Peter O. Awinda, Mei Methawasin, Henk Granzier, Wen-Ji Dong, Bertrand C.W. Tanner
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat. RNA Binding Motif P
Externí odkaz:
https://doaj.org/article/b49bae09e6e340938e4d40deb327d6f9
Autor:
Kyrah L. Turner, Haley S. Morris, Peter O. Awinda, Daniel P. Fitzsimons, Bertrand C.W. Tanner
Publikováno v:
Journal of General Physiology. 155
Hypertrophic cardiomyopathy (HCM) is the leading genetic cause of heart disease. The heart comprises several proteins that work together to properly facilitate force production and pump blood throughout the body. Cardiac myosin binding protein-C (cMy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0996fef9b861813bd545f5a9eb5078
https://doi.org/10.1085/jgp.202213250
https://doi.org/10.1085/jgp.202213250
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Seetharamaiah Attili, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell
Publikováno v:
Journal of General Physiology. 155
In healthy hearts, myofilaments become more sensitive to Ca2+ as the myocardium is stretched. This effect is known as length-dependent activation and is an important cellular-level component of the Frank–Starling mechanism. Few studies have measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2dffbc1c0a3742a1ea5ac92ad6d6a4
https://doi.org/10.1085/jgp.202213200
https://doi.org/10.1085/jgp.202213200
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B Agonias, Marissa Watanabe, Danuta Szczesna-Cordary, Anna M Huckabee, Katarzyna Kazmierczak, Yemeserach Bishaw
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H881-H890
Mavacamten is a pharmaceutical that binds to myosin, and it is under investigation as a therapy for some forms of heart disease. We show that mavacamten reduces isometric tension and Ca2+ sensitivity of contraction in skinned myocardial strips from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a40277588c30da2939131bbd1bfbd1
https://doi.org/10.1152/ajpheart.00345.2020
https://doi.org/10.1152/ajpheart.00345.2020
Autor:
Yemeserach Bishaw, Maya Guglin Guglin, Kenneth S. Campbell, Marissa Watanabe, Bertrand C.W. Tanner, Peter O. Awinda
Publikováno v:
British Journal of Pharmacology. 177:5609-5621
Background and purpose Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca2+ as cells are stretched. This represents a fundamental property of the myocardium th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac58bbaa4e722425cf02fc247d5e9a9b
https://doi.org/10.1111/bph.15271
https://doi.org/10.1111/bph.15271
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e202c43f178cc54f96384ddd6f51bd37
https://doi.org/10.2139/ssrn.4088694
https://doi.org/10.2139/ssrn.4088694
Publikováno v:
Biophys J
Heart failure is a life-threatening condition that occurs when the heart muscle becomes weakened and cannot adequately circulate blood and nutrients around the body. Omecamtiv mecarbil (OM) is a compound that has been developed to treat systolic hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f24036dac28bb6d669a71c4fb37387
https://doi.org/10.1016/j.bpj.2019.04.020
https://doi.org/10.1016/j.bpj.2019.04.020
Autor:
Peter O, Awinda, Marissa, Watanabe, Yemeserach, Bishaw, Anna M, Huckabee, Keinan B, Agonias, Katarzyna, Kazmierczak, Danuta, Szczesna-Cordary, Bertrand C W, Tanner
Publikováno v:
Am J Physiol Heart Circ Physiol
Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9556d1c34ff2f57d61885ae211b80d11
https://pubmed.ncbi.nlm.nih.gov/33337957
https://pubmed.ncbi.nlm.nih.gov/33337957
Autor:
Bertrand C.W. Tanner, Yemeserach Bishaw, Peter O. Awinda, Maya Guglin Guglin, Marissa Watanabe, Kenneth S. Campbell
Background and Purpose: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca2+ as cells are stretched. This represents a fundamental property of myocardium that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801e5f625cd417489be1c83ba39f6eff
https://doi.org/10.22541/au.158878883.32913834
https://doi.org/10.22541/au.158878883.32913834
