Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Peter O'Toole"'
Autor:
Roel Tans, Shoumit Dey, Nidhi Sharma Dey, Jian-Hua Cao, Prasanjit S. Paul, Grant Calder, Peter O’Toole, Paul M. Kaye, Ron M. A. Heeren
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionSpatial analysis of lipids in inflammatory microenvironments is key to understand the pathogenesis of infectious disease. Granulomatous inflammation is a hallmark of leishmaniasis and changes in host and parasite lipid metabolism have bee
Externí odkaz:
https://doaj.org/article/3fc2fac6fab04f08a4fd9e1e0d0cb1b9
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Autor:
Roel Tans, Shoumit Dey, Nidhi Sharma Dey, Grant Calder, Peter O’Toole, Paul M. Kaye, Ron M. A. Heeren
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Infectious diseases, including those of viral, bacterial, fungal, and parasitic origin are often characterized by focal inflammation occurring in one or more distinct tissues. Tissue-specific outcomes of infection are also evident in many infectious
Externí odkaz:
https://doaj.org/article/ca327b98146541949807b51df1a1e228
Autor:
Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control. This study explored the concept that endothelial cells (EC) cu
Externí odkaz:
https://doaj.org/article/d82e69fbad2e40a69c3165dbc4a8a766
Autor:
Daria Mizza, Peter O'Toole
Publikováno v:
Je-LKS: Journal of E-Learning and Knowledge Society, Vol 3, Iss 3 (2012)
This paper illustrates the theoretical basis, methodological conception, and innovative instructional design of an e-learning support for the development of writing skills of Italian as foreign language university students (University of Warwick, Gre
Externí odkaz:
https://doaj.org/article/b80e3c080ede43399d1ee88a4c3a6413
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18796 (2011)
Cell shape and tissue architecture are controlled by changes to junctional proteins and the cytoskeleton. How tissues control the dynamics of adhesion and cytoskeletal tension is unclear. We have studied epithelial tissue architecture using 3D cultur
Externí odkaz:
https://doaj.org/article/61a7473fe79849eb91f19a1598f2156f
Autor:
Urs Mörbe, Rita Pinter, Mariagrazia Uguccioni, Charles J.N. Lacey, Mark Coles, Marcus Thelen, Mark C. Leake, Zhaoukun Zhou, Natalia Pikor, Jason Cosgrove, Tom Cupedo, Anne Thuery, Jens V. Stein, Jon Timmis, Jovana Cupovic, Stefan Albrecht, Manfred Heller, Bénédicte Manoury, Kieran Alden, Mario Novkovic, Daniel F. Legler, Helen Miller, Burkhard Ludewig, Wojciech G. Polak, Marlene Wolf, Andrew Coatesworth, Daniel Venetz, Lucas Onder, Emily Taylor, Peter O'Toole, Simon Jarrett
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cosgrove, Jason; Novkovic, Mario; Albrecht, Stefan; Pikor, Natalia B; Zhou, Zhaoukun; Onder, Lucas; Mörbe, Urs; Cupovic, Jovana; Miller, Helen; Alden, Kieran; Thuery, Anne; O'Toole, Peter; Pinter, Rita; Jarrett, Simon; Taylor, Emily; Venetz, Daniel; Heller, Manfred; Uguccioni, Mariagrazia; Legler, Daniel F; Lacey, Charles J; ... (2020). B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nature Communications, 11(1), p. 3677. Springer Nature 10.1038/s41467-020-17135-2
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, ⟨10.1038/s41467-020-17135-2⟩
Nature Communications, 11(1):3677. Nature Publishing Group
Cosgrove, Jason; Novkovic, Mario; Albrecht, Stefan; Pikor, Natalia B; Zhou, Zhaoukun; Onder, Lucas; Mörbe, Urs; Cupovic, Jovana; Miller, Helen; Alden, Kieran; Thuery, Anne; O'Toole, Peter; Pinter, Rita; Jarrett, Simon; Taylor, Emily; Venetz, Daniel; Heller, Manfred; Uguccioni, Mariagrazia; Legler, Daniel F; Lacey, Charles J; ... (2020). B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nature Communications, 11(1), p. 3677. Springer Nature 10.1038/s41467-020-17135-2
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, ⟨10.1038/s41467-020-17135-2⟩
Nature Communications, 11(1):3677. Nature Publishing Group
Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients.
Autor:
Joanne Marrison, William J. Brackenbury, Mark J. Hunt, Anna Simon, Andrew D. James, Ming Yang, Paul M. Kaye, Peter O'Toole, Miles A. Whittington, Sangeeta Chawla
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understanding of this
Autor:
Aimee Joanna Gamble, Paul H. Walton, Joanne Marrison, Michael P. O'Hagan, M. Carmen Galan, Hazel A. Sparkes, Peter O'Toole, Jason M. Lynam, Dan E Wise, Karen Hogg, Paul G. Pringle, Sham Arkawazi
Publikováno v:
Dalton Transactions. 49:15219-15230
We report cytotoxic ruthenium(II) complexes of the general formula [RuCl(cis-tach)(diphosphine)]+ (cis-tach = cis–cis-1,3,5-triaminocyclohexane) that have been characterised by 1H, 13C and 31P{1H} NMR spectroscopy, mass spectrometry, X-ray crystall
With phenotypic heterogeneity in whole cell populations widely recognised, the demand for quantitative and temporal analysis approaches to characterise single cell morphology and dynamics has increased. We present CellPhe, a pattern recognition toolk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9021501a595cb5b292e89d574f5f7674
https://doi.org/10.21203/rs.3.rs-971415/v1
https://doi.org/10.21203/rs.3.rs-971415/v1