Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Peter Nehls"'
Autor:
Paul J. A. Borm, Peter Nehls, P.A.E.L. Schilderman, Roel P. F. Schins, Joachim Bruch, Frank Seiler, Ad M. Knaapen
Publikováno v:
Free Radical Biology and Medicine, 27(1-2), 234-240. Elsevier Science
Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands.Inflammation has been recognized as a contributing factor in the pathogenesis of some cancers. In the lung, inflammation is characterized by an influx of polymo
Autor:
Karsten Rothbarth, Ruth Greferath, Tova Glaser, Eberhard Spiess, Thomas Keck, Peter Nehls, Hermann Stammer, Dieter Werner
Publikováno v:
Nucleic Acids Research. 26:1160-1166
Polypeptides remaining tightly associated with isolated genomic DNA are of interest with respect to their potential involvement in the topological organization and/or function of genomic DNA. Such residual DNA-polypeptide complexes were used for rais
Autor:
Ruth Greferath, Peter Nehls
Publikováno v:
Hybridoma. 16:189-193
Monoclonal antibodies specific for thymidine glycol in oxidized DNA were generated by immunization with thymidine glycol monophosphate (TMP-OH) or thymidine glycol (T-OH), respectively, conjugated to keyhole limpet hemocyanin (KLH) or thyreoglobulin
Publikováno v:
Environmental Health Perspectives
Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjuncti
Autor:
Uta Pich, Pawel Baranczewski, Rigomar Rieger, Peter Nehls, Manfred F. Rajewsky, Ingo Schubert
Publikováno v:
Environmental and Molecular Mutagenesis. 29:394-399
Mutagen-induced chromatid aberrations are not randomly distributed along the metaphase chromosomes. In the field bean (Vicia faba), defined late-replicating and transcriptionally inactive heterochromatic regions are preferentially involved. After exp
Publikováno v:
Environmental and Molecular Mutagenesis. 29:400-405
Previously it was shown that the clastogenic efficiency of high doses of alkylating agents in plant root meristems can be reduced significantly by conditioning pretreatment with either a low dose of the same agents, a sublethal heat shock, or heavy m
Publikováno v:
Carcinogenesis. 16:2637-2641
The urinary excretion of the DNA alkylation products 3-methyladenine (3-MeAde) and 3-ethyladenine (3-EtAde) after controlled exposure to cigarette smoke over a period of 4 days was determined by competitive radioimmunoassay after separation by HPLC.
Publikováno v:
Nucleosides and Nucleotides. 12:463-477
A combination of H-phoshonate and phosphoramidite chemistry has been applied for the automated solid-phase synthesis of oligodeoxyribonucleotides containing 7, 8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) residues at predefined positions. The unmodi
Publikováno v:
Proceedings of the National Academy of Sciences. 87:9883-9887
O6-Ethylguanine (O6-EtGua) is one of about a dozen different alkylation products formed in the DNA of cells exposed to the alkylating N-nitroso carcinogen N-ethyl-N-nitrosourea (EtNU). We have evaluated selectively the relative capacity of cells for
Autor:
Manfred F. Rajewsky, Peter Nehls
Publikováno v:
Carcinogenesis. 11:81-87
We describe a rapid and sensitive, monoclonal antibody (mAb)-based immunoassay that permits the quantitation of cellular enzymatic activity for repair of specific carcinogen-DNA adducts. The assay was established on the basis of the observation that