Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peter N. Gillette"'
Autor:
Alexander Pinhas, MD, Justin V. Migacz, PhD, Davis B. Zhou, MD, Maria V. Castanos Toral, MD, Oscar Otero-Marquez, MD, Sharon Israel, BA, Vincent Sun, MD, Peter N. Gillette, MD, Nripun Sredar, PhD, Alfredo Dubra, PhD, Jeffrey Glassberg, MD, Richard B. Rosen, MD, Toco Y.P. Chui, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100196- (2022)
Purpose: Clinical OCT angiography (OCTA) of the retinal microvasculature offers a quantitative correlate to systemic disease burden and treatment efficacy in sickle cell disease (SCD). The purpose of this study was to use the higher resolution of ada
Externí odkaz:
https://doaj.org/article/c90d98bc544d40e481492029be4ba97b
Publikováno v:
Advances in Enzymology and Related Areas of Molecular Biology, Volume 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60295245e4f8996e130b5457e4485a09
https://doi.org/10.1002/9780470122853.ch1
https://doi.org/10.1002/9780470122853.ch1
Autor:
James M. Manning, Peter N. Gillette, Njifutei Njikam, Wanda M. Jones, Alan M. Nigen, Robley C. Williams
Publikováno v:
Journal of Biological Chemistry. 248:8052-8056
Carbamylation of the NH2-terminal valine residues of hemoglobin by cyanate in vitro is about 2½ times as extensive in partially deoxygenated whole blood (40 to 50% oxygen saturation) as in fully oxygenated whole blood. When the carbamylated α and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382583ac46f42286dbf5c642f4deeafc
https://doi.org/10.1016/s0021-9258(19)43192-x
https://doi.org/10.1016/s0021-9258(19)43192-x
Publikováno v:
Annals of the New York Academy of Sciences. 179:611-624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44f3f62fa2791ded461c583c57d2b59
https://doi.org/10.1111/j.1749-6632.1971.tb46937.x
https://doi.org/10.1111/j.1749-6632.1971.tb46937.x
Publikováno v:
American Journal of Obstetrics and Gynecology. 105:813-847
The liver has been shown to be the major site for conversion of various steroids. The steroids in turn have biologic effects on the liver. This review summarizes the influence that estrogens and progestins have on the function of the liver in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c094af68c85e21287bef6518d1fcf6b8
https://doi.org/10.1016/0002-9378(69)90017-9
https://doi.org/10.1016/0002-9378(69)90017-9
Publikováno v:
American Journal of Obstetrics and Gynecology. 108:227-231
The concentrations of 11 plasma proteins were determined in 25 women in the third trimester of pregnancy, 31 women who had taken oral contraceptive agents containing synthetic estrogens and progestins for 3 months or longer, and 31 women of comparabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2809c9519a11be603b74a297d02fce3
https://doi.org/10.1016/0002-9378(70)90301-7
https://doi.org/10.1016/0002-9378(70)90301-7
Publikováno v:
Journal of Experimental Medicine. 138:754-763
Patients with the genetic liver disease, acute intermittent porphyria (AIP), have a defect in the reductive transformation of steroid hormones that is manifest by the disproportionate generation of 5ß-steroid metabolites from precursor hormones. 5ß
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223554928c71d8a046a93678fb2af9ce
https://doi.org/10.1084/jem.138.4.754
https://doi.org/10.1084/jem.138.4.754
Publikováno v:
Proceedings of the National Academy of Sciences. 68:2791-2793
Cyanate reacts with the amino-terminal valine residues of hemoglobin S and prevents the sickling in vitro of 50-80% of the erythrocytes from patients with sickle-cell disease. The purpose of the studies reported here was to determine whether this ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4453adaa09b85b19d0e5e81c739ac786
https://doi.org/10.1073/pnas.68.11.2791
https://doi.org/10.1073/pnas.68.11.2791
Publikováno v:
The New England journal of medicine. 290(12)
Thirty-one patients with sickle-cell disease, seven to 49 years of age, were given the antisickling drug sodium cyanate (10 to 35 mg per kilogram of body weight per day by mouth) for six to 18 months. Carbamylation of the amino-terminal valine of hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba46f9d3ce8b82cafec86d61c79d1fea
https://pubmed.ncbi.nlm.nih.gov/4813727
https://pubmed.ncbi.nlm.nih.gov/4813727
Publikováno v:
Hemoglobin and Red Cell Structure and Function ISBN: 9781468432244
The purpose of the first clinical study with cyanate (Gillette, et al., 1971) was to determine whether the anti-sickling effect observed in vitro (Cerami and Manning, 1971) would also occur in vivo. Since the life span of erythrocytes from patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8154a107d895684018ce3c105739eec4
https://doi.org/10.1007/978-1-4684-3222-0_22
https://doi.org/10.1007/978-1-4684-3222-0_22