Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer

Autor: Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König, Marian Grade

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth factor (EGF) receptors H

Externí odkaz: https://doaj.org/article/6b00a26effe1468b968df1dc6e299f26

Oxaliplatin-Induced Leukocytoclastic Vasculitis under Adjuvant Chemotherapy for Colorectal Cancer: Two Cases of a Rare Adverse Event

Autor: Henriette Quack, Luise Erpenbeck, Hendrik A. Wolff, Thilo Sprenger, Cornelia S. Seitz, Michael P. Schön, Steffen Neumann, Kathrin Stanek, B. Michael Ghadimi, Beate Michels, Peter Middel, Inga-Marie Schaefer, Torsten Liersch, Lena-Christin Conradi

Publikováno v: Case Reports in Oncology, Vol 6, Iss 3, Pp 609-615 (2013)

Leukocytoclastic vasculitis is a multicausal systemic inflammatory disease of the small vessels, histologically characterized by inflammation and deposition of both nuclear debris and fibrin in dermal postcapillary venules. The clinical picture typic

Externí odkaz: https://doaj.org/article/fa063515e38a4c9ea38338a24576acdc

Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer

Autor: Lena-Christin, Conradi, Melanie, Spitzner, Anna-Lena, Metzger, Merle, Kisly, Peter, Middel, Hanibal, Bohnenberger, Jochen, Gaedcke, Michael B, Ghadimi, Torsten, Liersch, Joseph, Rüschoff, Tim, Beißbarth, Alexander, König, Marian, Grade

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancer

Background Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth factor (EGF) receptors HER-2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2ebaf40c8079facf3b21cf5635905551
http://resolver.sub.uni-goettingen.de/purl?gs-1/16375

Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study

Autor: Dirk Arnold, Lena Conradi, Emmanouil Fokas, Rolf Sauer, Franz Rödel, Josef Rüschoff, Kathrin Dellas, Peter Middel, Christian Weiss, Tillman Rau, B. Michael Ghadimi, Thilo Sprenger, Claus Rödel, Tim Beissbarth, Torsten Liersch, Julia Kitz

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 87:992-999

Purpose We have previously shown that the addition of cetuximab to chemoradiation therapy failed to improve complete response rates (pCR) in rectal cancer. Here we report the long-term results of the cetuximab added to preoperative radiation therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590d460c9b8f3f30eed43f98408f628
https://doi.org/10.1016/j.ijrobp.2013.09.011

Reproducibility of Immunohistochemical Scoring for Epidermal Growth Factor Receptor Expression in Non–Small Cell Lung Cancer: Round Robin Test

Autor: Reinhard Büttner, Anja von Heydebreck, Peter Middel, Stephan Störkel, Stephan E. Baldus, Venâncio Avancini Ferreira Alves, Ilhan Celik, Anthony W. I. Lo, Lina Carvalho, Josef Rüschoff, Włodzimierz T. Olszewski, Keith M. Kerr, Alexander Marx, Marco Volante, Ludger Fink, Wolfram Jochum, Erik Thunnissen, Ralf J. Rieker, Hans Jürgen Grote, Fritz Wrba, Fernando Lopez-Rios, Thierry Jo Molina

Publikováno v: Archives of pathology & laboratory medicine, 137(9), 1255-1261. College of American Pathologists
Ruschoff, J, Kerr, K M, Grote, H J, Middel, P, von Heydebreck, A, Alves, V A, Baldus, S E, Buttner, R, Carvalho, L, Fink, L, Jochum, W, Lo, A W I, Lopez-Rios, F, Marx, A, Molina, T J, Olszewski, W T, Rieker, R J, Volante, M, Thunnissen, E, Wrba, F, Celik, I & Storkel, S 2013, ' Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test ', Archives of pathology & laboratory medicine, vol. 137, no. 9, pp. 1255-1261 . https://doi.org/10.5858/arpa.2012-0605-OA

The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors expressed high levels of epidermal growth factor receptor (EGFR; immunohistochemistry score of ≥

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8365899fb9d0c78a7f44e70e9feb09fa
https://doi.org/10.5858/arpa.2012-0605-oa