Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5

Autor: Yang Li, Denise B. Kandel, Kimberly A. Kempadoo, Luca Colnaghi, Eric R. Kandel, Philippe A. Melas, Royce Zhou, Edmund A. Griffin, Mei-Chen Hu, Peter Mercado, Stacy Stephenson, Kathleen M. Taylor

Publikováno v: Science Advances

Prior alcohol use increases vulnerability to cocaine addiction by promoting degradation of HDAC4 and HDAC5.
Addiction to cocaine is commonly preceded by experiences with legal or decriminalized drugs, such as alcohol, nicotine, and marijuana. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1dc1d713b08090138a9744e1eb1ddd
https://doi.org/10.1126/sciadv.1701682

A systems view of epithelial–mesenchymal transition signaling states

Autor: Filippo Petti, Jonathan F. Bean, Stuart Thomson, David Epstein, Melissa Monaghan, John D. Haley, Gretchen M. Argast, Peter Mercado, Sean L. Seymour, Izabela Sujka-Kwok

Publikováno v: Clinical & Experimental Metastasis

Abtract Epithelial–mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancers. While considerable effort has focused in the regulators involved in the transition process, we have focused on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27338cd1cd063fcda5f4eb72f02a4ead
https://doi.org/10.1007/s10585-010-9367-3

The evaluation of E-Cadherin and vimentin as biomarkers of clinical outcomes among patients with non-small cell lung cancer treated with erlotinib as second- or third-line therapy

Autor: Frank, Richardson, G David, Young, Regina, Sennello, Julie, Wolf, Gretchen M, Argast, Peter, Mercado, Angela, Davies, David M, Epstein, Bret, Wacker

Publikováno v: Anticancer research. 32(2)

E-Cadherin and vimentin protein expression was assessed in late stage non-small cell lung cancer tumors from the placebo controlled clinical trial, NCIC-CTG BR.21, to determine if these markers had the potential to predict outcome of erlotinib therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb8d8fbb6cb52d36592c383203865f84
https://pubmed.ncbi.nlm.nih.gov/22287743

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis

Autor: Jan Bauer, Peter Mercado, Katerina Akassoglou, Ryan A. Adams, Hans Lassmann, Sidney Strickland, Vivian Tseveleki, Lesley Probert

Publikováno v: Akassoglou, K; Adams, R A; Bauer, J; Mercado, P; Tseveleki, V; Lassmann, H; et al.(2004). Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6698-6703. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/34d0d512

In multiple sclerosis, in which brain tissue becomes permeable to blood proteins, extravascular fibrin deposition correlates with sites of inflammatory demyelination and axonal damage. To examine the role of fibrin in neuroinflammatory demyelination,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d220619e148d1ce103aa076f17ebd078
http://www.escholarship.org/uc/item/34d0d512

Abstract 3370: The role of epithelial to mesenchymal transition (EMT) in resistance to Erlotinib in EGFR mutant NSCLC cell line models

Autor: Kenneth K. Iwata, Andrew Chau, David Epstein, Eric N. Brown, Stuart Thomson, Peter Mercado, Mark Miglarese, Maryland Rosenfeld-Franklin, Gretchen M. Argast

Publikováno v: Cancer Research. 71:3370-3370

The EGFR kinase inhibitor erlotinib is approved as a maintenance therapy in 1st line NSCLC as well as for treatment of 2nd/3rd line NSCLC and in combination with Gemcitabine for pancreatic cancer. It has been observed that the most pronounced respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d68ad27daf12e2e2d94176bcb15a3d31
https://doi.org/10.1158/1538-7445.am2011-3370