Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis

Autor: Martin Bauer, Edith Lackner, Peter Matzneller, Valentin Al Jalali, Sahra Pajenda, Vincent Ling, Christof Böhler, Werner Braun, Reinhard Braun, Maximilian Boesch, Patrick M. Brunner, Markus Zeitlinger

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Ablative fractional laser treatment facilitates epidermal drug delivery, which might be an interesting option to increase the topical efficacy of biological drugs in a variety of dermatological diseases. This work aims at investigating safety and tol

Externí odkaz: https://doaj.org/article/35a28d421c484dd4a323a99afeaa73b4

Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers

Autor: Angela Elma Edwina, Birgit C. P. Koch, Anouk E. Muller, Valentin al Jalali, Peter Matzneller, Markus Zeitlinger, Sebastiaan D. T. Sassen

Publikováno v: European Journal of Clinical Pharmacology, 79(6), 775-787. Springer-Verlag

Purpose A population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing regimens were evaluated in terms of the probability of target attainment for Escherichia coli using bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743ad422e173bcc2993316c0b4b58749
https://pure.eur.nl/en/publications/0ab58750-99e3-4cf7-bbbc-fdfdf2fb1327

Perception of clinical research among patients and healthy volunteers of clinical trials

Autor: Felix Bergmann, Peter Matzneller, Maria Weber, Lusine Yeghiazaryan, Thorsten Fuereder, Thomas Weber, Markus Zeitlinger

Publikováno v: European Journal of Clinical Pharmacology. 78:1647-1655

Purpose Clinical research relies on data from patients and volunteers, yet the target sample size is often not achieved. Here, we assessed the perception of clinical research among clinical trial participants to improve the recruitment process for fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937523809bcc3b12ed494ab442b5ebf6
https://doi.org/10.1007/s00228-022-03366-3

Microdosing as a Potential Tool to Enhance Clinical Development of Novel Antibiotics: A Tissue and Plasma PK Feasibility Study with Ciprofloxacin

Autor: Zoe Oesterreicher, Sabine Eberl, Beatrix Wulkersdorfer, Peter Matzneller, Claudia Eder, Esther van Duijn, Wouter H. J. Vaes, Birgit Reiter, Thomas Stimpfl, Walter Jäger, Alina Nussbaumer-Proell, Daniela Marhofer, Peter Marhofer, Oliver Langer, Markus Zeitlinger

Publikováno v: Clinical pharmacokinetics. 61(5)

Background and Objective In microdose studies, drug pharmacokinetics is measured in humans after administration of subtherapeutic doses. While previous microdose studies focused primarily on plasma pharmacokinetics, we set out to evaluate the feasibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdcdc00e9b78ff6083e23e89d240751
https://pubmed.ncbi.nlm.nih.gov/34997559

Binding of temocillin to plasma proteins in vitro and in vivo

Autor: Perrin Ngougni Pokem, Peter Matzneller, Steven Vervaeke, Xavier Wittebole, Lieven Goeman, Marie Coessens, Eleonora Cottone, Arnaud Capron, Beatrix Wulkersdorfer, Pierre Wallemacq, Johan W Mouton, Anouk E Muller, Markus Zeitlinger, Pierre François Laterre, Paul M Tulkens, Françoise Van Bambeke

Publikováno v: Journal of Antimicrobial Chemotherapy, Vol. 77, no. 10, p. 2742-2753 (2022)
Journal of Antimicrobial Chemotherapy, 77(10). Oxford University Press

Background Temocillin plasma protein binding (PPB) in healthy individuals is reported to be ∼85% but had not been studied in patients. Objectives To obtain normative data on temocillin PPB in patients in relation to infection and impact of co-medic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8703e96ef0dd1175206639832f64db
https://pure.eur.nl/en/publications/603e3c7f-84d6-4782-a8d5-3d8768a857dc