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Akademický článek

A KRAS-responsive long non-coding RNA controls microRNA processing

Autor: Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brullé-Soumaré, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O’Keefe, Michela Garofalo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may

Externí odkaz: https://doaj.org/article/befd75df391041c7bcbc529acaf3af0c

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Akademický článek

Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition

Autor: Athanasios R Paliouras, Marta Buzzetti, Lei Shi, Ian J Donaldson, Peter Magee, Sudhakar Sahoo, Hui‐Sun Leong, Matteo Fassan, Matthew Carter, Gianpiero Di Leva, Matthew G Krebs, Fiona Blackhall, Christine M Lovly, Michela Garofalo

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-16 (2020)

Abstract A subset of lung adenocarcinomas is driven by the EML4‐ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on‐target mutations or parallel pathwa

Externí odkaz: https://doaj.org/article/6544b05e1c244d05b4afe550ea63b803

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Akademický článek

Methodologies for the investigation of corroded iron objects: examples from prehistoric sites in South-eastern Arabia and Western Iran

Autor: Ivan Stepanov, Lloyd Weeks, Kristina Franke, Charlotte Cable, Bruno Overlaet, Peter Magee, Marc Händel, Yaaqoub Yousif Al Aali, Mansour Boraik Radwan, Hassan Zein

Publikováno v: Science and Technology of Archaeological Research, Vol 3, Iss 2, Pp 270-284 (2017)

Ancient iron objects from early Iron Age archaeological sites are almost always severely corroded, which can severely limit the possibilities for their archaeometallurgical analysis. In this paper, a range of corroded iron objects from different site

Externí odkaz: https://doaj.org/article/e094f41bd7334cdca00f70c63cf404a9

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Akademický článek

The Achaemenid Expansion to the Indus and Alexander’s Invasion of North-West South Asia

Autor: Cameron Petrie, Peter Magee

Publikováno v: Iranian Journal of Archaeological Studies, Vol 2, Iss 1, Pp 1-25 (2012)

There is a range of evidence that informs us about the organisation of the Achaemenid Empire, but our understanding ofthe eastern-most reaches of the empire, which lie within the bounds of modern-day Pakistan is relatively limited. Whilethere is evid

Externí odkaz: https://doaj.org/article/86859e8692cb4ce79497a9b16f9e44e7

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Elektronická kniha

The Archaeology of Prehistoric Arabia : Adaptation and Social Formation From the Neolithic to the Iron Age

Autor: Peter Magee

Encompassing a landmass greater than the rest of the Near East and Eastern Mediterranean combined, the Arabian peninsula remains one of the last great unexplored regions of the ancient world. This book provides the first extensive coverage of the arc

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