Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Peter M.J. Bos"'
Publikováno v:
Tobacco Induced Diseases, Vol 14, Iss July (2016)
Externí odkaz:
https://doaj.org/article/1028af50e43145b59c2ecdb5aac291eb
Autor:
Anne S. Kienhuis, Lya G Soeteman-Hernandez, Peter M.J. Bos, Hans WJM Cremers, Walther N Klerx, Reinskje Talhout
Publikováno v:
Tobacco Induced Diseases, Vol 13, Iss June (2015)
Background A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shis
Externí odkaz:
https://doaj.org/article/ffa6f5dcf28d4a7785f5dcaed478f988
Autor:
Lianne de Wit-Bos, Minne B. Heringa, Peter M.J. Bos, Jacqueline G. M. van Engelen, Liesbeth Geraets
Societal concern for animal welfare and scientific concerns about the predictive power of animal models for the human situation are driving forces for the development of animal-free approaches for the safety testing of chemicals. A paradigm shift tow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d1a4186e89b6996734a5210254ea21
http://hdl.handle.net/10029/623999
http://hdl.handle.net/10029/623999
Autor:
Michael L. Shuler, Delilah F. G. Hendriks, Betty C. Hakkert, Alicia Paini, Peter M.J. Bos, Bart Spee, Marije Strikwold, Ian Sorrell, Paul Jennings, Ans Punt, Huan Yang, Hans Bouwmeester, Bas J. Blaauboer, Minne B. Heringa, Meike van der Zande, Rosalinde Masereeuw, Martijn Rooseboom, Ad A. C. M. Peijnenburg, Mathieu Vinken, Andries D. van der Meer, Sandra Coecke, Nynke I. Kramer, Sibylle Neuhoff
Publikováno v:
ALTEX.
For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d506975c9be110527fa44b2ace726336
https://doi.org/10.14573/altex.2003242
https://doi.org/10.14573/altex.2003242
Autor:
Elisa C.M. Tonk, Petra C. E. van Kesteren, Peter M.J. Bos, Esther F.A. Brandon, Aldert H. Piersma, Jan C. H. van Eijkeren, Patricia Lopez Sanchez, Marc Tienstra
Publikováno v:
Regulatory Toxicology and Pharmacology 73 (2015) 1
Regulatory Toxicology and Pharmacology, 73(1), 55-64
Regulatory Toxicology and Pharmacology, 73(1), 55-64
The current risk assessment of compounds is generally based on external exposure and effect relationships. External doses are often not representative for internal exposure concentrations. The aim of this study was to show how the implementation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39189a94a12e67acc7d6ef515666b36
https://doi.org/10.1016/j.yrtph.2015.06.018
https://doi.org/10.1016/j.yrtph.2015.06.018
Autor:
Peter M.J. Bos, R.Z. Boerleider, J. Meulenbelt, B. G. H. Hof, I. de Vries, J.G.M. Bessems, Claudine C. Hunault, J.C.H. van Eijkeren, J.D.N. Olie
Publikováno v:
Toxicology Letters, 232(1), 21. Elsevier BV
Introduction Physiologically based pharmacokinetic (PBPK) models may be useful in emergency risk assessment, after acute exposure to chemicals, such as dichloromethane (DCM). We evaluated the applicability of three PBPK models for human risk assessme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9231a1dec705f6babd53db04dc0df54
https://doi.org/10.1016/j.toxlet.2014.10.010
https://doi.org/10.1016/j.toxlet.2014.10.010
Publikováno v:
Toxicology Letters. 231:324-327
Biological monitoring is a useful tool to assess occupational and environmental exposure following a wide range of chemical incidents. Guidance values are available from international organisations to help interpret the result of biological monitorin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793d1cdd29ca22488efddc06d291dd59
https://doi.org/10.1016/j.toxlet.2014.06.026
https://doi.org/10.1016/j.toxlet.2014.06.026
Autor:
Nelly E. van Brederode, Paul T.J. Scheepers, Nicole J. Nijhuis, Martin L. Eggens, Peter M.J. Bos, Irene van der Woude, Rik H.J. van de Weerdt
Publikováno v:
Toxicology Letters, 231, 3, pp. 295-305
Toxicology Letters, 231, 295-305
Toxicology Letters, 231, 295-305
Item does not contain fulltext Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097e1ca5502f7ddb6cc32e0a33962625
https://doi.org/10.1016/j.toxlet.2014.03.002
https://doi.org/10.1016/j.toxlet.2014.03.002
Publikováno v:
Toxicology letters. 282
Human health risk assessment of inhalation exposures generally includes a high-to-low concentration extrapolation. Although this is a common step in human risk assessment, it introduces various uncertainties. One of these uncertainties is related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f40a34ef19d705c9c27e2c2a223b42
https://pubmed.ncbi.nlm.nih.gov/29030269
https://pubmed.ncbi.nlm.nih.gov/29030269
Publikováno v:
Regulatory Toxicology and Pharmacology. 70:54-64
In toxicity testing the oral route is in general the first choice. Often, appropriate inhalation and dermal toxicity data are absent. Risk assessment for these latter routes usually has to rely on route-to-route extrapolation starting from oral toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb11fd175b215776fa26f0d2814d9acf
https://doi.org/10.1016/j.yrtph.2014.05.024
https://doi.org/10.1016/j.yrtph.2014.05.024