Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Peter M. Zygmunt"'
Autor:
Liying Zhang, Charlotte Simonsen, Lucie Zimova, Kaituo Wang, Lavanya Moparthi, Rachelle Gaudet, Maria Ekoff, Gunnar Nilsson, Ute A. Hellmich, Viktorie Vlachova, Pontus Gourdon, Peter M. Zygmunt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-
Externí odkaz:
https://doaj.org/article/39ad6ca731ce46dbb34893218be33cf8
Autor:
Lavanya Moparthi, Viktor Sinica, Vamsi K. Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R. Filipovic, Viktorie Vlachova, Peter M. Zygmunt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors report how the cold and heat sensing properties of the pain receptor TRPA1 are separately modulated by the C-terminal intracellular domain, and in concert with either the S1–S4 or the S5–S6 transmembrane domain.
Externí odkaz:
https://doaj.org/article/82871199457c46ae864c798a7f5cf7dd
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
The human TRPA1 (hTRPA1) is an intrinsic thermosensitive ion channel responding to both cold and heat, depending on the redox environment. Here, we have studied purified hTRPA1 truncated proteins to gain further insight into the temperature gating of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d201ee78e000e72dda31787732714b
https://doi.org/10.1101/2021.07.31.454589
https://doi.org/10.1101/2021.07.31.454589
Autor:
Peter M Zygmunt, Anna Ermund, Pouya Movahed, David A Andersson, Charlotte Simonsen, Bo A G Jönsson, Anders Blomgren, Bryndis Birnir, Stuart Bevan, Alain Eschalier, Christophe Mallet, Ana Gomis, Edward D Högestätt
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81618 (2013)
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that
Externí odkaz:
https://doaj.org/article/8dc9fcd4de7e4961b0b78813742bb4f0
Autor:
David A Barrière, Christophe Mallet, Anders Blomgren, Charlotte Simonsen, Laurence Daulhac, Frédéric Libert, Eric Chapuy, Monique Etienne, Edward D Högestätt, Peter M Zygmunt, Alain Eschalier
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70690 (2013)
The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 i
Externí odkaz:
https://doaj.org/article/810f4c07d97e42ef97cc02ab50bec1e6
Autor:
Peter M. Zygmunt, Per Kjellbom, Sven Kjellström, Milos R. Filipovic, Lavanya Moparthi, Urban Johanson
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6667, p 6667 (2020)
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6667, p 6667 (2020)
Volume 21
Issue 18
The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated by a wide range of chemicals, including the electrophilic compound N-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42778c1e28a28606ac4926be5ca7849
https://pubmed.ncbi.nlm.nih.gov/32933054
https://pubmed.ncbi.nlm.nih.gov/32933054
Publikováno v:
Cell Calcium
Cell Calcium, Elsevier, 2020, 90, pp.102228. ⟨10.1016/j.ceca.2020.102228⟩
Cell Calcium, 2020, 90, pp.102228. ⟨10.1016/j.ceca.2020.102228⟩
Cell Calcium, Elsevier, 2020, 90, pp.102228. ⟨10.1016/j.ceca.2020.102228⟩
Cell Calcium, 2020, 90, pp.102228. ⟨10.1016/j.ceca.2020.102228⟩
Extracellular influx of calcium or release of calcium from intracellular stores have been shown to activate mammalian TRPA1 as well as to sensitize and desensitize TRPA1 electrophilic activation. Calcium binding sites on both intracellular N- and C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe16a7f663d22f15e2f65b7c8468c89
Autor:
Lavanya Moparthi, Peter M. Zygmunt
The Transient Receptor Potential Ankyrin 1 (TRPA1) channel is an intrinsic chemo- and thermo-sensitive ion channel with distinct sensory signaling properties. Although a role of TRPA1 in mammalian mechanosensory transduction in vivo seems likely, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382354d8a2045a30bfc4a7b91dc03604
https://doi.org/10.1101/2020.03.05.979252
https://doi.org/10.1101/2020.03.05.979252
Autor:
Christophe Mallet, David A Barrière, Anna Ermund, Bo A G Jönsson, Alain Eschalier, Peter M Zygmunt, Edward D Högestätt
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12748 (2010)
Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular over-the-counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate
Externí odkaz:
https://doaj.org/article/0d3a139e7083454482747a8944cb98df