Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Peter M. Siegel"'
Autor:
Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, Peter M. Siegel
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103276- (2024)
Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously
Externí odkaz:
https://doaj.org/article/9541bdda466b464aac43f308bd0b1d8e
Autor:
Kyle Lewis, Rachel La Selva, Elias Maldonado, Matthew G. Annis, Ouafa Najyb, Eduardo Cepeda Cañedo, Stephanie Totten, Steven Hébert, Valérie Sabourin, Caitlynn Mirabelli, Emma Ciccolini, Camille Lehuédé, Luc Choinière, Mariana Russo, Daina Avizonis, Morag Park, Julie St-Pierre, Claudia L. Kleinman, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103028- (2024)
Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and pharmacological s
Externí odkaz:
https://doaj.org/article/8bcb1cc7a7684f09b3d926e68c5a0e4c
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Tight junctions (TJs) are large intercellular adhesion complexes that maintain cell polarity in normal epithelia and endothelia. Claudins are critical components of TJs, forming homo- and heteromeric interaction between adjacent cells, which have eme
Externí odkaz:
https://doaj.org/article/a7968040c399443e9207a9c1fe470deb
Autor:
Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacologi
Externí odkaz:
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
Autor:
Sébastien Tabariès, Matthew G. Annis, Anthoula Lazaris, Stephanie K. Petrillo, Jennifer Huxham, Amri Abdellatif, Vincent Palmieri, Jaclyn Chabot, Radia M. Johnson, Steven Van Laere, Cornelis Verhoef, Yasmina Hachem, Sara Yumeen, Nicholas Meti, Atilla Omeroglu, Gulbeyaz Altinel, Zu-Hua Gao, Alan S. L. Yu, Dirk J. Grünhagen, Peter Vermeulen, Peter Metrakos, Peter M. Siegel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tabariès et al. describe that claudin 2 is a promoter of colorectal cancer liver metastasis. Furthermore, high Claudin-2 expression is associated with shorter time to liver-specific recurrence and is a biomarker of replacement type CRC liver metasta
Externí odkaz:
https://doaj.org/article/e2e152566dcd484a9e2503811a8a2aa7
Autor:
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregu
Externí odkaz:
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Shivshankari Rajkumar, Diana Berry, Kayla A. Heney, Colton Strong, LeeAnn Ramsay, Mathieu Lajoie, Rached Alkallas, Tan-Trieu Nguyen, Cameron Thomson, Mozhdeh Ahanfeshar-Adams, Matthew Dankner, Teresa Petrella, April A.N. Rose, Peter M. Siegel, Ian R. Watson
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110634- (2022)
Summary: Although combination BRAF/MEK inhibition has produced significant survival benefits for BRAF p.V600 mutant melanomas, targeted therapies approved for BRAF non-p.V600 mutant melanomas remain limited. Through the analysis of 772 cutaneous mela
Externí odkaz:
https://doaj.org/article/640812e1a89846ff8e8c5f518bbb3180
Autor:
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate
Externí odkaz:
https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d
Autor:
Shufeng Zhou, Amani Hassan, Tenzin Kungyal, Sebastien Tabariès, José Luis Ramírez García Luna, Peter M. Siegel, Anie Philip
Publikováno v:
Cancers, Vol 14, Iss 15, p 3672 (2022)
(1) Background: Squamous cell carcinoma (SCC) is one of the leading causes of cancer-related deaths worldwide. CD109 is overexpressed in many cancers including SCC. Although a pro-tumorigenic role for CD109 has been shown in non-SCC cancers, and in o
Externí odkaz:
https://doaj.org/article/99f1b2a1d93842cc8e8b3d658d6bab0f
Autor:
Kerstin Tiedemann, Gulzhakhan Sadvakassova, Nicholas Mikolajewicz, Michal Juhas, Zarina Sabirova, Sébastien Tabariès, Jan Gettemans, Peter M. Siegel, Svetlana V. Komarova
Publikováno v:
Translational Oncology, Vol 12, Iss 3, Pp 462-474 (2019)
Bone metastasis from breast and prostate carcinomas is facilitated by activation of bone-resorbing osteoclasts. Using proteomics approaches, we have identified peroxiredoxin-4 (PRDX4) as a cancer-secreted mediator of osteoclastogenesis. We now report
Externí odkaz:
https://doaj.org/article/fbc1c28a7e1a4097bd14f3e8616976d1