Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Peter M. Savard"'
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Autor:
John J. Savarese, Peter M. Savard, Paul M. Heerdt, Jaideep K. Malhotra, Hiroshi Sunaga, Deena Godfrey, Joel S. Owen, Matthew T. Murrell, Michelle Steinkamp, Cynthia A. Lien
Publikováno v:
Anesthesiology. 125:1136-1143
BackgroundCW002 is a benzylisoquinolinium nondepolarizing neuromuscular-blocking drug found to be inactivated by cysteine in preclinical studies. The current study represents a dose escalation clinical trial designed to describe CW002 potency, durati
Autor:
Hiroshi Sunaga, John J. Savarese, Erin Jeannotte, Gilbert W. Carnathan, Paul M. Heerdt, Scott G. Van Ornum, Jaideep K. Malhotra, Matthew T. Murrell, Bryce J. Petty, Jeff D. McGilvra, Erica Allen, Peter M. Savard, Matthew R. Belmont
Publikováno v:
Anesthesiology. 125:732-743
Background CW002, a novel nondepolarizing neuromuscular blocking agent of intermediate duration, is degraded in vitro by l-cysteine; CW002-induced neuromuscular blockade (NMB) is antagonized in vivo by exogenous l-cysteine.1 Further, Institutional An
Autor:
Hiroshi, Sunaga, John J, Savarese, Jeff D, McGilvra, Paul M, Heerdt, Matthew R, Belmont, Scott G, Van Ornum, Matthew T, Murrell, Jaideep K, Malhotra, Peter M, Savard, Erin, Jeannotte, Bryce J, Petty, Erica, Allen, Gilbert W, Carnathan
Publikováno v:
Anesthesiology. 125(4)
CW002, a novel nondepolarizing neuromuscular blocking agent of intermediate duration, is degraded in vitro by L-cysteine; CW002-induced neuromuscular blockade (NMB) is antagonized in vivo by exogenous L-cysteine. Further, Institutional Animal Care an
Autor:
Hiroshi Sunaga, Matthew R. Belmont, John J. Savarese, Scott G. Van Ornum, Peter M. Savard, Jeff D. McGilvra, Paul M. Heerdt
Publikováno v:
Anesthesiology. 113:58-73
Background The ultra-short-acting neuromuscular blocker gantacurium is chemically degraded in vitro by rapid adduction of L-cysteine to its central olefinic double bond. Preliminary data have suggested that exogenous (intravenous) L-cysteine abolishe
Publikováno v:
Journal of Critical Care. 24:50-57
It has been almost 20 years since the introduction of the last new nondepolarizing neuromuscular blocking agent into clinical practice, and research is ongoing to fill a clinical need for a nondepolarizing agent with a fast onset of effect and a shor