Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peter M. Rademacher"'
Autor:
Isaac Mohar, Brendan D. Stamper, Peter M. Rademacher, Collin C. White, Sidney D. Nelson, Terrance J. Kavanagh
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 377-387 (2014)
The mechanism by which acetaminophen (APAP) causes liver damage evokes many aspects drug metabolism, oxidative chemistry, and genetic-predisposition. In this study, we leverage the relative resistance of female C57BL/6 mice to APAP-induced liver dama
Externí odkaz:
https://doaj.org/article/4a4c70ebc1494997ba14a87ad8ef85b1
Autor:
Judit Marsillach, Stephanie M Suzuki, Rebecca J Richter, Matthew G McDonald, Peter M Rademacher, Michael J MacCoss, Edward J Hsieh, Allan E Rettie, Clement E Furlong
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110054 (2014)
Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardiovascular, autoimmune and neurological diseases. Hu
Externí odkaz:
https://doaj.org/article/1fb2e390fbb54bd099f64d51bb0122ba
Autor:
Kevin J. Coe, Sidney D. Nelson, Mario Monshouwer, Bo Wen, William L. Fitch, Peter M. Rademacher
Publikováno v:
Chemical Research in Toxicology. 21:2393-2406
Flutamide (FLU), a nonsteroidal antiandrogen drug widely used in the treatment of prostate cancer, has been associated with idiosyncratic hepatotoxicity in patients. It is proposed that bioactivation of FLU and subsequent binding of reactive metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b61cad29111e588f27f475e4b9e1dd0
https://doi.org/10.1021/tx800281h
https://doi.org/10.1021/tx800281h
Autor:
Michael J. MacCoss, Allan E. Rettie, Rebecca J. Richter, Peter M. Rademacher, Stephanie M. Suzuki, Edward J. Hsieh, Judit Marsillach, Clement E. Furlong, Matthew G. McDonald
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e110054 (2014)
PLoS ONE, Vol 9, Iss 10, p e110054 (2014)
Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardiovascular, autoimmune and neurological diseases. Hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7c31822859f092804cf84c5ea35823
http://europepmc.org/articles/PMC4198189
http://europepmc.org/articles/PMC4198189
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(11)
Tienilic acid (TA) is selectively oxidized at the C-5 position of the thiophene ring by the human liver enzyme cytochrome P450 2C9 (CYP2C9). This oxidation is mediated by the proximal positioning of the thiophene over the heme iron, which is proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76daef682834879f482c37a9c52e56e
https://pubmed.ncbi.nlm.nih.gov/25187484
https://pubmed.ncbi.nlm.nih.gov/25187484
Autor:
Patricia E. Ganey, Sidney D. Nelson, Michael A. Scott, Peter M. Rademacher, Wei Zou, Robert A. Roth, Muireann Coen
Publikováno v:
Chemical research in toxicology. 25(11)
An NMR-based metabonomic approach was applied to study the systems level metabolic effects of two closely related thiophene compounds, tienilic acid (TA) and tienilic acid isomer (TAI). The metabonomic data were anchored with traditional clinical che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb036de15f72e492ebbe0fc0f5ff9ae3
https://pubmed.ncbi.nlm.nih.gov/23013248
https://pubmed.ncbi.nlm.nih.gov/23013248
The uricosuric diuretic agent tienilic acid (TA) is a thiophene-containing compound that is metabolized by P450 2C9 to 5-OH-TA. A reactive metabolite of TA also forms a covalent adduct to P450 2C9 that inactivates the enzyme and initiates immune-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38da9699cb4fc3c11078f341865cf71c
https://europepmc.org/articles/PMC3339269/
https://europepmc.org/articles/PMC3339269/
Autor:
Han Kiat Ho, Kevin J. Coe, Libby Woodke, Stephen R. Plymate, Frederico M. Farin, Sidney D. Nelson, Richard P. Beyer, Peter M. Rademacher, Yankai Jia, Theo K. Bammler, Nelson Fausto
Flutamide (FLU) is an antiandrogen primarily used in the treatment of metastatic prostate cancer. It is an idiosyncratic hepatotoxicant that sometimes results in severe liver toxicity. FLU possesses a nitroaromatic group, which may be a contributor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099460a5bc814650affe0bb412155b53
https://europepmc.org/articles/PMC2802183/
https://europepmc.org/articles/PMC2802183/