Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Peter M. Klein"'
Autor:
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined br
Externí odkaz:
https://doaj.org/article/9991808b163e4d46b294196caba44f82
Autor:
Nick A. Guagliardo, Peter M. Klein, Christina A. Gancayco, Adam Lu, Sining Leng, Rany R. Makarem, Chelsea Cho, Craig G. Rusin, David T. Breault, Paula Q. Barrett, Mark P. Beenhakker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Aldosterone-producing zona glomerulosa cells in the adrenal gland arrange into rosette structures known to be important for morphogenesis. Here the authors show that the cells in the rosettes produce coordinated calcium activity bursts in response to
Externí odkaz:
https://doaj.org/article/c1975079f3f541bbb5287c6fb622c60d
Autor:
Peter M. Klein, Vipan K. Parihar, Gergely G. Szabo, Miklós Zöldi, Maria C. Angulo, Barrett D. Allen, Amal N. Amin, Quynh-Anh Nguyen, István Katona, Janet E. Baulch, Charles L. Limoli, Ivan Soltesz
Publikováno v:
Neurobiology of Disease, Vol 151, Iss , Pp 105252- (2021)
Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching the neurological risks of GCR exposures, including during human spaceflight, various groun
Externí odkaz:
https://doaj.org/article/a66003fda2bc4ad48eb746cea77b12ee
Autor:
Peter M. Klein, Yasaman Alaghband, Ngoc-Lien Doan, Ning Ru, Olivia G. G. Drayson, Janet E. Baulch, Enikö A. Kramár, Marcelo A. Wood, Ivan Soltesz, Charles L. Limoli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9020 (2021)
A recognized risk of long-duration space travel arises from the elevated exposure astronauts face from galactic cosmic radiation (GCR), which is composed of a diverse array of energetic particles. There is now abundant evidence that exposures to many
Externí odkaz:
https://doaj.org/article/6b6932c1c0804a66b36028b49b4c46ae
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Neonatal seizures are commonly caused by hypoxic and/or ischemic injury during birth and can lead to long-term epilepsy and cognitive deficits. In a rodent hypoxic seizure (HS) model, we have previously demonstrated a critical role for seizure-induce
Externí odkaz:
https://doaj.org/article/73b69a770e9c4f0c90faf0e94c063574
Autor:
de Beer, Friso M., Bos, Lieuwe D.J., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Hoogendijk, Arie J., Huson, Mischa A., Klouwenberg, Peter M. Klein, Ong, David S.Y., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Scicluna, Brendon P *, van Vught, Lonneke A, Zwinderman, Aeilko H, Wiewel, Maryse A, Davenport, Emma E, Burnham, Katie L, Nürnberg, Peter, Schultz, Marcus J, Horn, Janneke, Cremer, Olaf L, Bonten, Marc J, Hinds, Charles J, Wong, Hector R, Knight, Julian C, van der Poll, Tom
Publikováno v:
In The Lancet Respiratory Medicine October 2017 5(10):816-826
Autor:
Jordan S. Farrell, Matthew Lovett-Barron, Peter M. Klein, Fraser T. Sparks, Tilo Gschwind, Anna L. Ortiz, Biafra Ahanonu, Susanna Bradbury, Satoshi Terada, Mikko Oijala, Ernie Hwaun, Barna Dudok, Gergely Szabo, Mark J. Schnitzer, Karl Deisseroth, Attila Losonczy, Ivan Soltesz
Publikováno v:
Science
Locomotion-related signals in the brain To calculate where we are in space, continuous knowledge of one’ s speed is necessary. How does the brain know how fast the body is traveling during locomotion? Using in vivo calcium imaging, electrophysiolog
Publikováno v:
Epilepsy Currents. 22:54-60
Epileptic seizures are associated with excessive neuronal spiking. Perisomatic γ-aminobutyric acid (GABA)ergic interneurons specifically innervate the subcellular domains of postsynaptic excitatory cells that are critical for spike generation. With
Autor:
Yasaman Alaghband, Peter M. Klein, Eniko A. Kramár, Michael N. Cranston, Bayley C. Perry, Lukas M. Shelerud, Alice E. Kane, Ngoc-Lien Doan, Ning Ru, Munjal M. Acharya, Marcelo A. Wood, David A. Sinclair, Dara L. Dickstein, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 80, iss 1
Technological advancements have facilitated the implementation of realistic, terrestrial-based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe central nervous system functionality. This work expands considerably on prior,
Autor:
Mark P. Beenhakker, Nick A. Guagliardo, Rany R. Makarem, Craig G. Rusin, Christina A. Gancayco, Chelsea Cho, Paula Q. Barrett, Sining Leng, Peter M. Klein, Adam C Lu, David T. Breault
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays function