Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter M. Kincey"'
Autor:
Gary T. Borrett, Graham R. Slater, Stephen A. Hermitage, Ian P. Andrews, Peter M. Kincey, Smith Neil, Mahesh J. Sanganee, Geracimos Rassias
Publikováno v:
Organic Process Research & Development. 13:774-780
The original medicinal chemistry synthesis of an iNOS inhibitor presented several challenges that had to be overcome in order to constitute a supply route suitable for operation on a multikilo scal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72df24bc2bd3724f8c202662671f764
https://doi.org/10.1021/op900108b
https://doi.org/10.1021/op900108b
Publikováno v:
Tetrahedron Letters. 42:1781-1784
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed220e7a9a75f7f3e26fa926a1e5432c
https://doi.org/10.1016/s0040-4039(00)02326-1
https://doi.org/10.1016/s0040-4039(00)02326-1
Autor:
David Bell, Peter M. Kincey, Graham Richard Geen, Mann Inderjit Singh, Frances Finney, Mark R. Davies
Publikováno v:
Tetrahedron Letters. 37:3895-3898
In the absence of a donor ligand both the reaction rate and product e.e. of the manganese (III) salen catalysed epoxidation of 2,2-dimethyl-6-pentafluoroethylchromene were dependent on the catalyst loading. Isoquinoline N-oxide was the most effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa6e6d9c52e8a3b0ba1be987e8f8b985
https://doi.org/10.1016/0040-4039(96)00683-1
https://doi.org/10.1016/0040-4039(96)00683-1
Autor:
Steven O'Donnell, Bernadette M. Choudary, J. Robert, Martin J. Parratt, Johnson Graham, David W. Tudor, Graham Richard Geen, M. Dales, Peter M. Kincey, Neil Woods
Publikováno v:
Nucleosides and Nucleotides. 15:981-994
Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad2e966aeba6ecbdab62f82390f1c54
https://doi.org/10.1080/07328319608002029
https://doi.org/10.1080/07328319608002029
Publikováno v:
ChemInform. 24
N-9 alkylated materials are the sole products obtained from extended reaction of 2-aminopurines (potential guanine precursors) with Michael acceptors. This was used as the basis for a highly regioselective synthesis of famciclovir, the oral form of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263f806fa5111ac477ce99d0af8a6df2
https://doi.org/10.1002/chin.199301209
https://doi.org/10.1002/chin.199301209
Autor:
J. R. M. Dales, Martin J. Parratt, N. Woods, S. O'donnell, Graham Richard Geen, Peter M. Kincey, Johnson Graham, Bernadette M. Choudary, D. W. Tudor
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2dd3a3ddd223a20d8558449a86fb1e
https://doi.org/10.1002/chin.199636232
https://doi.org/10.1002/chin.199636232
Publikováno v:
ChemInform. 32
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a7f0e142b2408e6324eb919c199d61
https://doi.org/10.1002/chin.200121191
https://doi.org/10.1002/chin.200121191
Publikováno v:
Tetrahedron Letters. 33:4609-4612
N-9 alkylated materials are the sole products obtained from extended reaction of 2-aminopurines (potential guanine precursors) with Michael acceptors. This was used as the basis for a highly regioselective synthesis of famciclovir, the oral form of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703f289a9335de1643fdc73a30d5ab6a
https://doi.org/10.1016/s0040-4039(00)61326-6
https://doi.org/10.1016/s0040-4039(00)61326-6
Publikováno v:
Tetrahedron. 46:6903-6914
A series of eleven 6-substituted 2-aminopurines was N-alkylated with 2-acetoxymethyl-4-iodobutyl acetate. The ratio of N-9 to N-7 alkylated products varied from 1.8:1 (6-methoxy) to 25:1 (6-isopropyl). The log of this ratio was found to correlate wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae5c6fb877fe2ed8bb9941273965a14d
https://doi.org/10.1016/s0040-4020(01)87878-9
https://doi.org/10.1016/s0040-4020(01)87878-9