Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Peter M. Kekenes-Huskey"'
Autor:
Byeong J. Chun, Surya P. Aryal, Peter Varughese, Bin Sun, Joshua A. Bruno, Chris I. Richards, Adam D. Bachstetter, Peter M. Kekenes-Huskey
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors. Purinergic receptor activation gives rise to diverse intracellular calcium (Ca2+ signals, or wa
Externí odkaz:
https://doaj.org/article/e65e478f8185437289780ecbf6341df1
Autor:
Bin Sun, Peter M. Kekenes-Huskey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The S100A1 protein regulates cardiomyocyte function through its binding of calcium (Ca2+) and target proteins, including titin, SERCA, and RyR. S100A1 presents two Ca2+ binding domains, a high-affinity canonical EF-hand (cEF) and a low-affinity pseud
Externí odkaz:
https://doaj.org/article/231d680276634eb8ad066e4940ab1e99
Autor:
Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1144 (2020)
Significant advances in our understanding of the molecular mechanisms that cause congenital long QT syndrome (LQTS) have been made. A wide variety of experimental approaches, including heterologous expression of mutant ion channel proteins and the us
Externí odkaz:
https://doaj.org/article/d221839e65a84164b8bd586edb236d23
Autor:
Kalyan Immadisetty, Xuan Fang, Geraldine San Ramon, Cassandra M. Hartle, Thomas P. McCoy, Regeneron Genetics Center, Tooraj Mirshahi, Brian P. Delisle, Peter M. Kekenes-Huskey
Publikováno v:
Journal of Molecular and Cellular Cardiology. 180:69-83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1ce65b6df614235e402a5a29406274
https://doi.org/10.1016/j.yjmcc.2023.05.002
https://doi.org/10.1016/j.yjmcc.2023.05.002
Publikováno v:
Biophys J
The P2X4 receptor plays a prominent role in cellular responses to extracellular ATP. Through classical all-atom molecular dynamics (MD) simulations totaling 24 µs we have investigated how metal-complexed ATP stabilizes the channel’s open state and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9981aa7febe853567fea9ac83836f4e3
https://doi.org/10.1016/j.bpj.2022.02.038
https://doi.org/10.1016/j.bpj.2022.02.038
Publikováno v:
Biophys J
Synapsed cells can communicate using exocytosed nucleotides like adenosine triphosphate (ATP). Ectonucleotidases localized to synaptic junctions degrade nucleotides into metabolites like adenosine monophosphate (AMP) or adenosine. Oftentimes nucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45856d4104f22628a7e82dedde8fdf
https://doi.org/10.1016/j.bpj.2021.12.013
https://doi.org/10.1016/j.bpj.2021.12.013
Publikováno v:
The Journal of Physical Chemistry B. 125:11520-11533
Silica-based materials including zeolites are commonly used for wide ranging applications including separations and catalysis. Substrate transport rates in these materials can significantly influence the efficiency of such applications. Two factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce9125688cb70b7e817a11a74f78421
https://doi.org/10.1021/acs.jpcb.1c07062
https://doi.org/10.1021/acs.jpcb.1c07062
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms
Autor:
Ryan B. Williams, Md Nure Alam Afsar, Svetlana Tikunova, Yongjun Kou, Xuan Fang, Radha P. Somarathne, Rita F. Gyawu, Garrett M. Knotts, Taylor A. Agee, Sara A. Garcia, Luke D. Losordo, Nicholas C. Fitzkee, Peter M. Kekenes-Huskey, Jonathan P. Davis, Christopher N. Johnson
Publikováno v:
Cell Calcium. 113:102752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b12be6149fdf56143c525bd4d3b7aaf
https://doi.org/10.1016/j.ceca.2023.102752
https://doi.org/10.1016/j.ceca.2023.102752
Publikováno v:
J Phys Chem B
Members of the parvalbumin (PV) family of calcium (Ca2+) binding proteins (CBPs) share a relatively high level of sequence similarity. However, their Ca2+ affinities and selectivities against competing ions like Mg2+ can widely vary. We conducted mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ddfcbe865087a2ba6deff22a31a665
https://doi.org/10.1021/acs.jpcb.1c01269
https://doi.org/10.1021/acs.jpcb.1c01269
Autor:
Maicon Landim-Vieira, Jose R. Pinto, Bin Sun, Elio A. Cino, Isela C. Valera, Peter M. Kekenes-Huskey, Karissa M. Dieseldorff Jones, Jamie R. Johnston, Adolfo H. Moraes, Michelle S. Parvatiyar, Jerson L. Silva, Guilherme A. P. de Oliveira, Vitold E. Galkin, P. Bryant Chase, Mayra A. Marques
Publikováno v:
Chemical Science
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca2+-regulation of myocardial contraction. Here, we report the molecular basis of a human mutation in cTnC's αD-helix (TNNC1-p.C84Y) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076a706144f657ad43c53f2d9b5ca239
https://doi.org/10.1039/d1sc01886h
https://doi.org/10.1039/d1sc01886h