Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Peter M. Kasson"'
Autor:
Mayuresh M. Abhyankar, Barbara J. Mann, Jeffrey M. Sturek, Savannah Brovero, G. Brett Moreau, Anjali Sengar, Crystal M. Richardson, Sayeh Agah, Anna Pomés, Peter M. Kasson, Mark A. Tomai, Christopher B. Fox, William A. Petri
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract We developed a SARS-CoV-2 spike subunit vaccine formulation containing dual TLR ligand liposome adjuvant. The vaccine-induced robust systemic neutralizing antibodies and completely protected mice from a lethal challenge. Two immunizations pr
Externí odkaz:
https://doaj.org/article/da4da1c7c88a4956b31769225afbc2c2
Publikováno v:
ACS Central Science, Vol 4, Iss 11, Pp 1503-1510 (2018)
Externí odkaz:
https://doaj.org/article/336deab3423b4fad8ba4753ae9ba876b
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009835 (2022)
Gmxapi provides an integrated, native Python API for both standard and advanced molecular dynamics simulations in GROMACS. The Python interface permits multiple levels of integration with the core GROMACS libraries, and legacy support is provided via
Externí odkaz:
https://doaj.org/article/ca90c90845eb4ff98837c3e4e76b4672
Structural prediction of chimeric immunogens to elicit targeted antibodies against betacoronaviruses
Autor:
Jamel Simpson, Peter M. Kasson
Publikováno v:
bioRxiv
Betacoronaviruses pose an ongoing pandemic threat. Antigenic evolution of the SARS-CoV-2 virus has shown that much of the spontaneous antibody response is narrowly focused rather than broadly neutralizing against even SARS-CoV-2 variants, let alone f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e8f071b39d431167611b401f087db7
https://europepmc.org/articles/PMC9915606/
https://europepmc.org/articles/PMC9915606/
Simulation datasets of proteins (e.g., those generated by molecular dynamics simulations) are filled with information about how the non-covalent interaction network within a protein regulates the conformation and thus function of said protein. Most p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267bb694a8cd30ae53bccf4770218b32
https://doi.org/10.26434/chemrxiv-2023-d0h8h
https://doi.org/10.26434/chemrxiv-2023-d0h8h
Publikováno v:
The journal of physical chemistry. B. 126(49)
The phospholipid bis(monoacylglycero)phosphate (BMP) is enriched in late endosomal and endo-lysosomal membranes and is believed to be involved in membrane deformation and generation of intralumenal vesicles within late endosomes. Previous studies hav
The SARS-CoV-2 coronavirus infects human cells via the ACE-2 receptor. Circumstantial evidence suggests that ACE-2 may not just serve as an attachment factor but also help activate the SARS-CoV-2 spike protein for membrane fusion. Here, we test that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0deb2c439f95c8be6824112cdf4c7237
https://doi.org/10.1101/2022.10.22.513347
https://doi.org/10.1101/2022.10.22.513347
Publikováno v:
Biophysical journal.
Neutralizing antibodies against influenza have generally been classified according to their recognition sites, with antibodies against the head domain of hemagglutinin thought to inhibit attachment and antibodies against the stalk region thought to i
Publikováno v:
Biophysical journal. 121(23)
The kinetics by which individual enveloped viruses fuse with membranes provide an important window into viral-entry mechanisms. We have developed a real-time assay using fluorescent probes for single-virus genome exposure than can report on stages of
Autor:
Marc Lipsitch, Wendy Barclay, Rahul Raman, Charles J Russell, Jessica A Belser, Sarah Cobey, Peter M Kasson, James O Lloyd-Smith, Sebastian Maurer-Stroh, Steven Riley, Catherine AA Beauchemin, Trevor Bedford, Thomas C Friedrich, Andreas Handel, Sander Herfst, Pablo R Murcia, Benjamin Roche, Claus O Wilke, Colin A Russell
Publikováno v:
eLife, Vol 5 (2016)
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by d
Externí odkaz:
https://doaj.org/article/b177bbbe82ff40c7ba95daee77f926c1