Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Peter M. Jordan"'
1
Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana
Autor: Peter M. Jordan, R M Jones
Publikováno v: Biochemical Journal. 299:895-902
Porphobilinogen deaminase (EC 4.3.1.8) has been purified to homogeneity (16,000-fold) from the plant Arabidopsis thaliana in yields of 8%. The deaminase is a monomer of M(r) 35,000, as shown by SDS/PAGE, and 31,000, using gel-filtration chromatograph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdae7567302f03c30e098def60c463ab
https://doi.org/10.1042/bj2990895
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2
5-Amino-6-hydroxy 3,4,5,6-tetrahydropyran-2-one (HAT): A stable, cyclic form of glutamate 1-semialdehyde, the natural precursor for tetrapyrroles
Autor: Martin J. Warren, Kwai-Ming Cheung, Peter M. Jordan, Ram P. Sharma
Publikováno v: Tetrahedron Letters. 34:1177-1180
Glutamate 1-semialdehyde is shown to exist in a cyclic form, 5-amino-6-hydroxy-3,4,5,6-tetrahydropyran-2-one (HAT), which explains its unexpectedly high stability for an α-aminoaldehyde. It is proposed that the cyclic form is the actual intermediate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a762b48bd8d35ab519dd700c005b577
https://doi.org/10.1016/s0040-4039(00)77521-6
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4
Mechanistic and stereochemical investigation of fatty acid and polyketide biosynthesis using chiral malonates
Autor: Jonathan B. Spencer, Peter M. Jordan
Publikováno v: Tetrahedron. 47:6015-6028
Chiral malonates, (R)-[1-13C;2-2H]malonate and (S)-[1-13C;2-2H]malonate, were synthesised and characterised as malonyl-CoA derivatives with yeast fatty acid synthase using mass spectrometric analysis of the palmitic acid produced. The chiral malonate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0810118a07caf8bdb48ecec8fae6d805
https://doi.org/10.1016/s0040-4020(01)86493-0
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6
The Biosynthesis of Uroporphyrinogen III: Mechanism of Action of Porphobilinogen Deaminase
Autor: Peter M. Jordan
Publikováno v: Ciba Foundation Symposium 180-The Biosynthesis of the Tetrapyrrole Pigments
The biosynthesis of the uroporphyrinogen III macrocycle from porphobilinogen requires the sequential participation of two enzymes--porphobilinogen deaminase (1-hydroxymethylbilane synthase, EC 4.3.1.8) and uroporphyrinogen III synthase (cosynthase, E
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa2cc1ef5f7ffffc7b534cb76534d62
https://doi.org/10.1002/9780470514535.ch5
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7
Structural Studies on Porphobilinogen Deaminase
Autor: Martin J. Warren, Gordon V. Louie, Sarah C. Woodcock, Peter M. Jordan, Paul D. Brownlie, Tom L. Blundell, Steve P. Wood, Richard Lambert, Cooper Jc
Publikováno v: Ciba Foundation Symposium 180-The Biosynthesis of the Tetrapyrrole Pigments
The X-ray crystallographic analysis of porphobilinogen deaminase (hydroxymethylbilane synthase, EC 4.3.1.8) shows the polypeptide chain folded into three domains, (1) N-terminal, (2) central and (3) C-terminal, of approximately equal size. Domains 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::820d0f41551c4f54d09804ec459239fe
https://doi.org/10.1002/9780470514535.ch6
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8
Crystallization and preliminary X-ray investigation of Escherichia coli porphobilinogen deaminase
Autor: Paul D. Brownlie, B I A Mgbeje, Jonathan B. Cooper, Richard Lambert, Peter M. Jordan, S.P. Wood, Gordon V. Louie, Martin J. Warren, Tom L. Blundell
Publikováno v: Journal of Molecular Biology. 224:269-271
Porphobilinogen deaminase, the polymerase that catalyses the synthesis of preuroporphyrinogen, the linear tetrapyrrole precursor of uroporphyrinogen III, has been crystallized from sodium acetate buffer with polyethylene glycol 6000 as precipitant. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a56062e14071a55fb3cdb8a886ed50f
https://doi.org/10.1016/0022-2836(92)90590-g
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9
Subcellular location of the tetrapyrrole synthesis enzyme porphobilinogen deaminase in higher plants: an immunological investigation
Autor: Michael Witty, Alison G. Smith, Russell M. Jones, Matthew S. Robb, Peter M. Jordan
Publikováno v: Planta. 199(4)
A recombinant plasmid, pArab8, harbouring the cDNA encoding the mature form of the tetrapyrrole synthesis enzyme porphobilinogen deaminase (EC 4.3.1.8; also known as hydroxymethylbilane synthase) from Arabidopsis thaliana (L.) Heynh. has been constru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbc8f15c8b5832d572b2ce23e9fb6f3
https://pubmed.ncbi.nlm.nih.gov/8818294
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10
Molecular basis of acute intermittent porphyria
Autor: Steve P. Wood, Richard Lambert, Peter M. Jordan
Publikováno v: Molecular medicine today. 1(5)
Acute intermittent porphyria is an inherited disease of haem biosynthesis that results from mutation of the gene for the enzyme porphobilinogen deaminase. Many different mutations have been located throughout the gene. The three-dimensional structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6d83e011e49ed140b77fe2dc8e8575
https://pubmed.ncbi.nlm.nih.gov/17607885
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