Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Peter M. J. Burgers"'
Autor:
Jessica A. Brown, Likui Zhang, Shanen M. Sherrer, John-Stephen Taylor, Peter M. J. Burgers, Zucai Suo
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Understanding polymerase fidelity is an important objective towards ascertaining the overall stability of an organism's genome. Saccharomyces cerevisiae DNA polymerase η (yPolη), a Y-family DNA polymerase, is known to efficiently bypass DNA lesions
Externí odkaz:
https://doaj.org/article/e9e7a06d990749278a423901d29da973
Autor:
Elena I. Stepchenkova, Piotr A. Mieczkowski, Thomas A. Kunkel, Adam B. Burkholder, Thomas D. Petes, Denis A. Kiktev, Peter M. J. Burgers, Margaret Dominska, Joseph Dahl, Scott A. Lujan, Tony Zhang
Publikováno v:
Nucleic Acids Research
Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19) gene of Saccharomyces cerevisiae as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8d3cda85e55d05e987d2244cf4b037
http://europepmc.org/articles/PMC8191807
http://europepmc.org/articles/PMC8191807
Publikováno v:
Nucleic Acids Research
DNA polymerase ζ (Pol ζ) and Rev1 are essential for the repair of DNA interstrand crosslink (ICL) damage. We have used yeast DNA polymerases η, ζ and Rev1 to study translesion synthesis (TLS) past a nitrogen mustard-based interstrand crosslink (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49628337bc4eb1007895ba5f0724792c
http://europepmc.org/articles/PMC7470978
http://europepmc.org/articles/PMC7470978
Autor:
Peter M. J. Burgers, Elias Tannous
Publikováno v:
Crit Rev Biochem Mol Biol
DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability of precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4dc33068da16027b10bb979846af0e
https://europepmc.org/articles/PMC8992879/
https://europepmc.org/articles/PMC8992879/
Publikováno v:
Journal of Biological Chemistry. 294:10120-10130
In Saccharomyces cerevisiae, Tel1 protein kinase, the ortholog of human ataxia telangiectasia–mutated (ATM), is activated in response to DNA double-strand breaks. Biochemical studies with human ATM and genetic studies in yeast suggest that recruitm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9999fb4418515255cd09dc3c0a0382f8
https://doi.org/10.1074/jbc.ra119.008410
https://doi.org/10.1074/jbc.ra119.008410
Publikováno v:
Nucleic Acids Research
DNA polymerase delta (Pol δ) is responsible for the elongation and maturation of Okazaki fragments in eukaryotic cells. Proliferating cell nuclear antigen (PCNA) recruits Pol δ to the DNA and serves as a processivity factor. Here, we show that PCNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aca9ea39640ea72d04eeac77477305
https://doi.org/10.1093/nar/gky1321
https://doi.org/10.1093/nar/gky1321
Publikováno v:
Nature structural & molecular biology
In response to DNA damage or replication fork stalling, the basal activity of Mec1ATR is stimulated in a cell-cycle-dependent manner, leading to cell-cycle arrest and the promotion of DNA repair. Mec1ATR dysfunction leads to cell death in yeast and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba02d23d1ab527ed3c7a10b79fe46213
http://hdl.handle.net/10044/1/84053
http://hdl.handle.net/10044/1/84053
Publikováno v:
J Biol Chem
Successful DNA replication requires carefully regulated mechanisms to overcome numerous obstacles that naturally occur throughout chromosomal DNA. Scattered across the genome are tightly bound proteins, such as transcription factors and nucleosomes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec8dac80f534bb5900ff8b74283b7fb
https://pubmed.ncbi.nlm.nih.gov/32913126
https://pubmed.ncbi.nlm.nih.gov/32913126
Publikováno v:
DNA Repair (Amst)
The Exo5 family consists of bi-directional, single-stranded DNA-specific exonucleases that contain an iron-sulfur cluster as a structural motif and have multiple roles in DNA metabolism. S. cerevisiae Exo5 is essential for mitochondrial genome mainte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aceb81ec49ab4430ed9b47611783f11
https://europepmc.org/articles/PMC6990415/
https://europepmc.org/articles/PMC6990415/
Autor:
Jennifer A. Cobb, Peter M. J. Burgers, John H.J. Petrini, Barry S. Taylor, Fiorella Ghisays, Marcel Hohl, Dinshaw J. Patel, Matthew T. Chang, Sarem Hailemariam, Vitaly Kuryavyi, Kyle Sorenson, Aditya Mojumdar
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb38763df458c0e79dd3ff038d72d01