Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Peter M. Hoogerbrugge"'
Autor:
K.L. Juliëtte Schmidt, Noortje R. Severeijns, Noël M.M. Dautzenberg, Peter M. Hoogerbrugge, Caroline A. Lindemans, Stefan Nierkens, Gaby Smits, Rob S. van Binnendijk, Marta Fiocco, Louis J. Bont, Wim J.E. Tissing
Publikováno v:
EJC Paediatric Oncology, Vol 4, Iss , Pp 100172- (2024)
Externí odkaz:
https://doaj.org/article/bd17b0d91811492f9104cb0ec180123b
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N. van Leeuwen
Publikováno v:
HemaSphere, Vol 7, Iss 5, p e875 (2023)
IKZF1 deletions are an established prognostic factor in childhood acute lymphoblastic leukemia (ALL). However, their relevance in patients with good risk genetics, namely ETV6::RUNX1 and high hyperdiploid (HeH), ALL remains unclear. We assessed the p
Externí odkaz:
https://doaj.org/article/5645c5c18f97430d84ab7aaaba94a6bf
Autor:
Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper
Publikováno v:
Haematologica, Vol 106, Iss 12 (2020)
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes. However, the clinical relevance of these subclonal alte
Externí odkaz:
https://doaj.org/article/9dc8ce692dab4b10b6bd519bb4040df0
Autor:
Jiangyan Yu, Esmé Waanders, Simon V. van Reijmersdal, Željko Antić, Charlotte M. van Bosbeek, Edwin Sonneveld, Hester de Groot, Marta Fiocco, Ad Geurts van Kessel, Frank N. van Leeuwen, Rob Pieters, Peter M. Hoogerbrugge, Roland P. Kuiper
Publikováno v:
HemaSphere, Vol 4, Iss 1, p e318 (2020)
Abstract. Genomic alterations in relapsed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) may provide insight into the role of specific genomic events in relapse development. Along this line, comparisons between the spectrum of alterations in
Externí odkaz:
https://doaj.org/article/9ea5833e05c3444d86e26bd16b66e6d5
Autor:
Renske J. E. van den Bijgaart, Michiel Kroesen, Ingrid C. Brok, Daphne Reijnen, Melissa Wassink, Louis Boon, Peter M. Hoogerbrugge, Gosse J Adema
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is the primary target for the development of neurobla
Externí odkaz:
https://doaj.org/article/1e1ec552e48646038e1f6be9869c3425
Autor:
Blanca Scheijen, Judith M. Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T. van der Meer, Rob Pieters, Gabriele Escherich, Martin A. Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P. Kuiper, Peter M. Hoogerbrugge, Monique L. den Boer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or n
Externí odkaz:
https://doaj.org/article/4b9e33dbdf0346af888f8b42df273b6a
Autor:
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Jørn Havinga, Jean-Pierre Rouault, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Blanca Scheijen
Publikováno v:
Haematologica, Vol 101, Iss 7 (2016)
Externí odkaz:
https://doaj.org/article/39dc79da08df40628fc4a89891ab5776
Autor:
Nicole Herijgers, Menno P.J. de Winther, Miranda Van Eck, Louis M. Havekes, Marten H. Hofker, Peter M. Hoogerbrugge, Theo J.C. Van Berkel
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 9, Pp 1402-1409 (2000)
Scavenger receptors, which include various classes, play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins, resulting in the massive accumulation of cholesteryl esters. Because macrophage-derived foam ce
Externí odkaz:
https://doaj.org/article/89c52cc426bb495e94d599e405d0d85e
Autor:
Nicole Herijgers, Miranda Van Eck, Suzanne J.A. Korporaal, Peter M. Hoogerbrugge, Theo J.C. Van Berkel
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 7, Pp 1163-1171 (2000)
We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL re
Externí odkaz:
https://doaj.org/article/4f331d5d4ff54bb090d4e744108dfe26