Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter M. Hobart"'
Autor:
Steve P. Wood, Kieran F. Geoghegan, Peter M. Hobart, B. L. Sibanda, M. Badasso, C. G. Dealwis, M.P. Newman, B. A. O’Connor, C. Aguilar, Mark Ammirati, Dennis J. Hoover, Ian J. Tickle, Carlos Frazão, V. Dhanaraj, Dennis E. Danley, Tom L. Blundell, Jon B. Cooper, H.P.C. Driessen
Publikováno v:
Nature. 357:466-472
X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3355ba138c0a02b4c22ffdeda71f5e
https://doi.org/10.1038/357466a0
https://doi.org/10.1038/357466a0
Autor:
Javier Sueiras-Diaz, Tom L. Blundell, Kazuo Murakami, Mark Ammirati, Jon B. Cooper, S.P. Wood, H. Miyazaki, Dennis E. Danley, M. Szelke, D. M. Jones, Peter M. Hobart, B. L. Sibanda, M. Badasso, C. G. Dealwis, Dennis J. Hoover, Carlos Frazão, V. Dhanaraj, A. J. Lanzetti, B. A. O’Connor, Kieran F. Geoghegan
Publikováno v:
Journal of molecular biology. 223(2)
Inhibitor-complexed crystals of mouse and human renins suitable for X-ray analysis have been prepared. The mouse renin is complexed with a non-hydrolysable decapeptide analogue of rat angiotensinogen containing a hydroxyethylene isostere in place of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75867b0f74d5914336a459b34a141cc0
https://pubmed.ncbi.nlm.nih.gov/1738157
https://pubmed.ncbi.nlm.nih.gov/1738157
Autor:
A. J. Lanzetti, Dennis E. Danley, Peter M. Hobart, Mark Ammirati, Kieran F. Geoghegan, B. A. O’Connor
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468460148
The structural analysis of human renin’s active site is a critical component to understanding the enzyme’s exquisite specificity. Broad interest in the molecular basis of substrate recognition by renin is due in large part to its pivotal role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c841e5f6fa54ac1a061a4ec5edfe9fb
https://doi.org/10.1007/978-1-4684-6012-4_48
https://doi.org/10.1007/978-1-4684-6012-4_48
Autor:
S.Edward Lee, Peter John Whittle, Stephen Hawrylik, Andrew M. Hemmings, James Merson, James E. Pitts, John P. Overington, Kathryn Shield, Andrew F. Wilderspin, S. P. Wood, Kieran Francis Geoghegan, Laurence H. Pearl, R. Lapatto, Peter M. Hobart, Tom L. Blundell, Dennis Edward Danley, Duncan J. H. Gaskin, Zhang-Yang Zhu
Publikováno v:
Retroviral Proteases ISBN: 9780333536124
HIV-1 proteinase processes its virally encoded polyproteins into mature structural proteins and enzymes that are essential for viral propagation. As a consequence the proteinase is an attractive target for prospective antiviral agents for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344cecd549e9dbb42146cbca1fdbf640
https://doi.org/10.1007/978-1-349-11907-3_10
https://doi.org/10.1007/978-1-349-11907-3_10
Autor:
S.Edward Lee, Graham Rickett, Dennis E. Danley, Mark Ammirati, Kathryn G. Scheld, Peter M. Hobart, James R. Merson, Kieran F. Geoghegan, Steven J. Hawrylik
Publikováno v:
Biochemical and Biophysical Research Communications. 165:1043-1050
A plasmid vector was used to express the HIV-1 pol open reading frame under the regulation of the bacterial trp promoter in Escherichia coli. This expression system has been used as a source of recombinant viral protease. The self-processed active en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cb6e13bf0dbafd5b462b83fa0572c3
https://doi.org/10.1016/0006-291x(89)92707-1
https://doi.org/10.1016/0006-291x(89)92707-1
Publikováno v:
Journal of Biological Chemistry. 263:3137-3141
Mammalian cells in culture, transfected with human renin gene, can provide a useful tool for studying renin biosynthesis and secretion. We transfected fibroblast cells (mouse L929 and Chinese hamster ovary cells) and pituitary tumor cells (mouse AtT-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cd058b17628ae9b611f0cc331e6a253
https://doi.org/10.1016/s0021-9258(18)69046-5
https://doi.org/10.1016/s0021-9258(18)69046-5
Autor:
Chirgwin John Mitchell, Jasjit S. Bindra, Beryl W. Dominy, Peter M. Hobart, B. L. Sibanda, Tom L. Blundell, Michael Fogliano
Publikováno v:
FEBS Letters. 174:102-111
A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the 3-dimensional structure defined at high resolution for other homologous aspartic proteinases. Human renin can adopt a 3-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea27f521be4fe4dfd43c41c5ef12e39
https://doi.org/10.1016/0014-5793(84)81086-8
https://doi.org/10.1016/0014-5793(84)81086-8
Autor:
Shih-Jen Edward Lee, Steven J. Hawrylik, Stephen A. Wood, John P. Overington, Kathryn G. Scheld, Andrew M. Hemmings, Andrew F. Wilderspin, Dennis E. Danley, Peter John Whittle, R. Lapatto, Tom L. Blundell, James Merson, Peter M. Hobart, Kieran F. Geoghegan
Publikováno v:
Nature. 342:299-302
Knowledge of the tertiary structure of the proteinase from human immunodeficiency virus HIV-1 is important to the design of inhibitors that might possess antiviral activity and thus be useful in the treatment of AIDS. The conserved Asp-Thr/Ser-Gly se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b9bc36bc5b414a3a2ed397a8096b9
https://doi.org/10.1038/342299a0
https://doi.org/10.1038/342299a0
Autor:
Chirgwin John Mitchell, Peter M. Hobart, Barbra A. O'Connor, Ida M. Schaefer, Michael Fogliano
Publikováno v:
Proceedings of the National Academy of Sciences. 81:5026-5030
The complete protein precursor of human kidney renin has been determined from the sequence of cloned genomic DNA. The gene spans 12 kilobases of DNA and is interrupted by eight intervening sequences. The nine regions (exons) encoding the protein were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21e6ec01af4d1444a62316eae85b79f
https://doi.org/10.1073/pnas.81.16.5026
https://doi.org/10.1073/pnas.81.16.5026
Autor:
David W. Burt, John Chirgwin, Victor J. Dzau, Roger R. Williams, Martin Paul, A J Naftilan, Peter M. Hobart, Richard E. Pratt
Publikováno v:
Scopus-Elsevier
Because renin is an important enzyme in blood pressure regulation, we studied the possibility that an alteration in the structure of the human renin gene is genetically linked to human essential hypertension or associated with levels of plasma renin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7eaf606a33218d3b6b14e47af312a60
https://pubmed.ncbi.nlm.nih.gov/2573574
https://pubmed.ncbi.nlm.nih.gov/2573574