Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peter M. Finan"'
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 75K, This file contains detailed descriptions of materials and methods that had to be omitted from the main manuscript due to space limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c98b6b1a6e0d1506dc7ac17ab9bf49
https://doi.org/10.1158/2159-8290.22528515.v1
https://doi.org/10.1158/2159-8290.22528515.v1
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 59K, This file contains additional experimental data relating to the profile of JAA120, secretome screening results, gene expression data, and in vivo MET/FGR inhibitor synergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8822d966da43dd533bf0e796b84a95c8
https://doi.org/10.1158/2159-8290.22528509
https://doi.org/10.1158/2159-8290.22528509
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 310K, This file contains additional experimental data relating to ligand-mediated rescue and drug combinations in cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6056ab23a9ee72d9ae3c3a8094ae846e
https://doi.org/10.1158/2159-8290.22528518
https://doi.org/10.1158/2159-8290.22528518
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
XLS file - 147K, Expression of selected RTKs and cognate ligands in cancer cell lines as a basis for selecting models for testing of FGFR/MET inhibitor combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356e72ceed31e9513e886aea92daa0c2
https://doi.org/10.1158/2159-8290.22528512
https://doi.org/10.1158/2159-8290.22528512
Autor:
Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Anupama Reddy, Elina Pradhan, Rita Das, Joseph Lehár, Robert Schlegel, Peter M Finan, Z Alexander Cao, Leon O Murphy, Alan Huang
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48548 (2012)
The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric mTOR inhibitor that has shown marked effic
Externí odkaz:
https://doaj.org/article/32cb2963c67d49559e5f3173e7cb5b38
Autor:
Heinz Ruffner, Fred Harbinski, Arun Ramamurthy, Jeremy L. Jenkins, Tewis Bouwmeester, Lac Lee, Paola Grandi, Jennifer A. DaSilva, Barbara Wilmeringwetter, Rishi K. Jain, Showalter Todd, Luis Llamas, Frederic Bassilana, Aaron Bourret, Adam Carlson, Jeffrey A. Porter, Xu Wu, Solange Vidal, Peter M. Finan, Pascal Rigollier, Markus Schirle, Joseph Kelleher, Bianka L. Grosshans, Klaus Seuwen, Samantha Plonsky, John A. Tallarico, Valerie Beck, Andreas W. Sailer, Sarah J. Luchansky, Vic E. Myer
Publikováno v:
Nature Chemical Biology. 10:343-349
Hedgehog (Hh) signaling determines cell fate during development and can drive tumorigenesis. We performed a screen for new compounds that can impinge on Hh signaling downstream of Smoothened (Smo). A series of cyclohexyl-methyl aminopyrimidine chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776a437136d93c82505cb7a23b5e468a
https://doi.org/10.1038/nchembio.1481
https://doi.org/10.1038/nchembio.1481
Publikováno v:
FEBS Letters. 432:5-8
Synaptojanin1, the major constitutively active PtdInsP3 5-phosphatase activity in rat brain, is one of two closely related proteins both extensively spliced in their C-terminal proline rich domain. We describe here the discovery of a novel splice var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a707cd1e2d85d3d0ad9c3ca6ffcc13
https://doi.org/10.1016/s0014-5793(98)00820-5
https://doi.org/10.1016/s0014-5793(98)00820-5
Publikováno v:
Plant Molecular Biology. 25:59-67
Protein sequence data derived from the N-terminal region of a 17 kDa polypeptide associated with the microsomal membrane fraction from Pisum sativum was used to design degenerate oligonucleotides which were used to amplify P. sativum cDNA via the pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5b941935e133cbd099a675728768a
https://doi.org/10.1007/bf00024198
https://doi.org/10.1007/bf00024198
Publikováno v:
Journal of Plant Physiology. 142:191-196
Summary Anion exchange chromatography of microsomal membrane polypeptides prepared from etiolated Pisum sativum hypocotyls generated 3 fractions of proteins which exhibited high affinity GTPγS binding. Scatchard analysis of the major binding fractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8a908117326a3ea8c9dc562875f362a
https://doi.org/10.1016/s0176-1617(11)80962-4
https://doi.org/10.1016/s0176-1617(11)80962-4
Autor:
Peter J. Parker, Peter M. Finan, Nicholas F. Totty, Rüdiger Woscholski, J. Justin Hsuan, Mike Waterfield, Alistair E. Sterling, Elizabeth Radley
Publikováno v:
The Journal of biological chemistry. 272(15)
The major constitutive phosphatidylinositol-3,4,5-P3 (PtdIns) 5-phosphatase activity was purified and subjected to peptide sequence analysis providing extensive amino acid sequence which was subsequently used for cloning the cDNA. Peptide and cDNA se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d01634fa0853dd6faac1636a625174
https://pubmed.ncbi.nlm.nih.gov/9092489
https://pubmed.ncbi.nlm.nih.gov/9092489