Výsledky vyhledávání - "Peter M. Esch"

Good Laboratory Practice (GLP)- guidelines for the validation of computerised systems

Autor: Leo Hutter, Peter M. Esch, Bruno Eschbach, Hans Peter Saxer, Stephan Hassler, Gérard Donzé, Roger Zühlke, Uwe Timm

Publikováno v: The Quality Assurance Journal. 11:208-220

The aim of this document is to provide guidance on the validation of computerised systems, compliant with Good Laboratory Practice (GLP). It specifies more precisely the procedures to follow in carrying out validations of computerised systems. It int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f74cef35dc1865a13fa079e955101b55
https://doi.org/10.1002/qaj.426

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Good Laboratory Practice (GLP) - guidelines for the acquisition and processing of electronic raw data in a GLP environment

Autor: Hansruedi Hartmann, Uwe Timm, Gérard Donzé, Bruno Eschbach, Peter M. Esch, Leo Hutter, Hans Peter Saxer, Stephan Hassler

Publikováno v: The Quality Assurance Journal. 10:3-14

The aim of the present document is to provide guidance on the Good Laboratory Practice (GLP)-compliant acquisition and processing of electronic raw data. The life cycle of electronic raw data and their related meta data from the data acquisition to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f77ce6ca02a0d94bc5a32f89d6e87090
https://doi.org/10.1002/qaj.356

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ChemInform Abstract: Formic Acid-Induced π-Cyclization of Glycine Cation Equivalents to Substituted Pipecolic Acid Derivatives

Autor: Henk Hiemstra, R. F. De Boer, Ilona M Boska, W. N. Speckamp, Peter M. Esch

Publikováno v: ChemInform. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::946bda51cc49c856264cafccbfd359a5
https://doi.org/10.1002/chin.199135164

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ChemInform Abstract: Intermolecular Reactions of N-Alkoxycarbonyliminium Ions with Propargyltrimethylsilane; Oxazinone versus Allene Formation

Autor: W. N. Speckamp, Peter M. Esch, Henk Hiemstra

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43504014daf8db5328fce696aea6a1b1
https://doi.org/10.1002/chin.199234184

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ChemInform Abstract: Reductive Cyclization of Carbon-Centered Glycine Radicals; A Novel Synthetic Route to Cyclic α-Amino Acids

Autor: Henk Hiemstra, Peter M. Esch, R. F. De Boer, W. N. Speckamp

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f21ef90f75c5d857bbab8f02e3ecd9
https://doi.org/10.1002/chin.199239273

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Intermolecular reacitons of N-alkoxycarbonyliminium ions with propargyltrimethylsilane; oxazinone versus allene formation

Autor: W. Nico Speckamp, Peter M. Esch, Henk Hiemstra

Publikováno v: Tetrahedron. 48:3445-3462

Intermolecular reactions of N-alkoxycarbonyliminium ions with propargyltrimethylsilane mainly lead to 6-(trimethylsilyl)methyl-3,4-dihydro-2H-1,3-oxazinones, formed by intramolecular trapping of a stabilized β-silyl vinylic cation. α-Allenyl carbam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a795276302340b2a193d5351814ffb5d
https://doi.org/10.1016/0040-4020(92)85018-a

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Reductive cyclization of carbon-centered glycine radicals; a novel synthetic route to cyclic α-amino acids

Autor: Peter M. Esch, W. Nico Speckamp, Henk Hiemstra, Richard F. de Boer

Publikováno v: Tetrahedron. 48:4659-4676

Reductive cyclizations (tributylin hydride, AIBN) of several α-(penthylthio)glycine derivatives with a 30alkenyl substituent at nitrogen are reported. These reactions proceed via 2-aza-5-alken-1-yl radicals as intermediates which bear electron-withd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bfab575469da23765093e402486e738
https://doi.org/10.1016/s0040-4020(01)81240-0

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Tin tetrachloride-induced π-cyclizations of glycine cation equivalents to substituted pipecolic acid derivatives

Autor: W. Nico Speckamp, Henk Hiemstra, Peter M. Esch, Richard F. de Boer, Ilona M Boska

Publikováno v: Tetrahedron. 47:4039-4062

Cationic π-cyclization reactions of N-(3-alkenyl)-N-(methoxycarbonyl)acetoxyglycine esters induced by tin tetrachloride in dichloromethane are described. Reactions started and quenched with water at-78 °C mainly yield cis-4-hydroxypipecolic esters,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef4f43b58364d6f8ec56e0d433b1d9e6
https://doi.org/10.1016/s0040-4020(01)86443-7

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Formic acid-induced π-cyclization of glycine cation equivalents to substituted pipecolic acid derivatives

Autor: Speckamp W. Nico, de Boer F Richard, Ilona M Boska, Peter M. Esch, Hiemstra Henk

Publikováno v: Tetrahedron. 47:4063-4076

Formic acid-mediated cyclization reactions of N-(3-alkenyl)-N-(methoxycarbonyl)-acetoxyglycine esters are described. The major reaction products are 4-formyloxypipecolic acid derivatives, formed with low stereoselectivity at C-4. The several subtle f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ae530d6604dcb6f584fc40a6e49262a
https://doi.org/10.1016/s0040-4020(01)86444-9

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Synthesis of cyclic α-amino acids through ring closure of glycine derived free radicals

Autor: W. Nico Speckamp, Peter M. Esch, Henk Hiemstra

Publikováno v: Tetrahedron Letters. 31:759-762

Cyclizations of 1-methoxycarbonyl-2-aza-5-hexenyl (and related) radical intermediates proceed in good yields and constitute a novel synthetic route to proline and pipecolic acid analogues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b512afb81414b27a7208a3133e97d48f
https://doi.org/10.1016/s0040-4039(00)94622-7

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