Zobrazeno 1 - 10
of 670
pro vyhledávání: '"Peter M Visscher"'
Autor:
Xiaotong Wang, Valentin Hivert, Shiane Groot, Ying Wang, Loic Yengo, John J McGrath, Kathryn E Kemper, Peter M Visscher, Naomi R Wray, Joana A Revez
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011033 (2023)
Vitamin D status-a complex trait influenced by environmental and genetic factors-is tightly associated with skin colour and ancestry. Yet very few studies have investigated the genetic underpinnings of vitamin D levels across diverse ancestries, and
Externí odkaz:
https://doaj.org/article/f88493a2708348eeb81b39239f4f8f1a
Autor:
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/49877892abd24e60be24474ec13ce578
Autor:
Jacob Gratten, Clemens R Scherzer, Sarah E Medland, Richard Parker, Simone Cross, Nicholas G Martin, Penelope A Lind, George D Mellick, Peter M Visscher, Danuta Z Loesch, Svetlana Bivol, Aoibhe Mulcahy, Philip E Mosley, Peter C Poortvliet, Adrian I Campos, Brittany L Mitchell, Luis M Garcia-Marin, Mary Ferguson, Miguel E Rentería
Publikováno v:
BMJ Open, Vol 12, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/893b816f46994f05b018ec9d05ee6aee
Autor:
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
Publikováno v:
eLife, Vol 11 (2022)
Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNA methylation (DNA
Externí odkaz:
https://doaj.org/article/97b5228535ef4e2596046a3a97ea7f67
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009548 (2021)
Fisher's partitioning of genotypic values and genetic variance is highly relevant in the current era of genome-wide association studies (GWASs). However, despite being more than a century old, a number of persistent misconceptions related to nonaddit
Externí odkaz:
https://doaj.org/article/99cdeb4ec3994acbbf4a8f5ff0f2079b
Autor:
Qian Zhang, Riccardo E Marioni, Matthew R Robinson, Jon Higham, Duncan Sproul, Naomi R Wray, Ian J Deary, Allan F McRae, Peter M Visscher
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals. Methods We performed a longitudinal analysis to quantify the variation in the rate of chang
Externí odkaz:
https://doaj.org/article/ea06486f289a4bf1a79f156881c4cce9
Autor:
Biaty Raymond, Loic Yengo, Roy Costilla, Chris Schrooten, Aniek C Bouwman, Ben J Hayes, Roel F Veerkamp, Peter M Visscher
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008780 (2020)
Genome-Wide Association Studies (GWAS) in large human cohorts have identified thousands of loci associated with complex traits and diseases. For identifying the genes and gene-associated variants that underlie complex traits in livestock, especially
Externí odkaz:
https://doaj.org/article/c869d064f46e493c9d883c8f6a3d9f1a
Autor:
Michael M Mendelson, Riccardo E Marioni, Roby Joehanes, Chunyu Liu, Åsa K Hedman, Stella Aslibekyan, Ellen W Demerath, Weihua Guan, Degui Zhi, Chen Yao, Tianxiao Huan, Christine Willinger, Brian Chen, Paul Courchesne, Michael Multhaup, Marguerite R Irvin, Ariella Cohain, Eric E Schadt, Megan L Grove, Jan Bressler, Kari North, Johan Sundström, Stefan Gustafsson, Sonia Shah, Allan F McRae, Sarah E Harris, Jude Gibson, Paul Redmond, Janie Corley, Lee Murphy, John M Starr, Erica Kleinbrink, Leonard Lipovich, Peter M Visscher, Naomi R Wray, Ronald M Krauss, Daniele Fallin, Andrew Feinberg, Devin M Absher, Myriam Fornage, James S Pankow, Lars Lind, Caroline Fox, Erik Ingelsson, Donna K Arnett, Eric Boerwinkle, Liming Liang, Daniel Levy, Ian J Deary
Publikováno v:
PLoS Medicine, Vol 14, Iss 1, p e1002215 (2017)
BackgroundThe link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain.Methods and findingsWe conducted an association study of body mass index (BMI) and differential methylation for over 400,0
Externí odkaz:
https://doaj.org/article/56619ceba5414f799e1f7b502d4b541e
Autor:
Yunpeng Wang, Wesley K Thompson, Andrew J Schork, Dominic Holland, Chi-Hua Chen, Francesco Bettella, Rahul S Desikan, Wen Li, Aree Witoelar, Verena Zuber, Anna Devor, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, Markus M Nöthen, Marcella Rietschel, Qiang Chen, Thomas Werge, Sven Cichon, Daniel R Weinberger, Srdjan Djurovic, Michael O'Donovan, Peter M Visscher, Ole A Andreassen, Anders M Dale
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005803 (2016)
Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linka
Externí odkaz:
https://doaj.org/article/86020116becc4d2e8c2e37ef3b213872
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1004969 (2015)
Gene discovery, estimation of heritability captured by SNP arrays, inference on genetic architecture and prediction analyses of complex traits are usually performed using different statistical models and methods, leading to inefficiency and loss of p
Externí odkaz:
https://doaj.org/article/3074812b8139401f9cd28a7177b5827b