Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Peter M Thulé"'
Autor:
Shuo You, Mallappa Anitha, Sean MD deSouza, Dingwu Jia, Xianghua Lu, Miroslaw Kozlowski, Darin E Olson, Shanthi Srinivasan, Peter M Thulé
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Depending on the population examined, from 6 to 83% of people with diabetes mellitus exhibit symptoms of altered gut motility, manifesting as dysphagia, reflux, early satiety, nausea, abdominal pain, diarrhea, or constipation. Hyperglycemia-induced c
Externí odkaz:
https://doaj.org/article/4cca0afd404843c7aadc912497bb4af5
Autor:
April Y. Maa, Darin E. Olson, Andrew Feola, Lukas Mees, Katie L. Bales, Peter M. Thulé, Rachael S Allen, Machelle T. Pardue, P. Michael Iuvone, Cara Motz, Andrew Hendrick, Kyle Chesler
Publikováno v:
Diabetes
Diabetic retinopathy (DR) is diagnosed clinically by directly viewing retinal vascular changes during ophthalmoscopy or through fundus photographs. However, electroretinography (ERG) studies in humans and rodents have revealed that retinal dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20481df4c1091b9342d9c574d854a0a3
https://pubmed.ncbi.nlm.nih.gov/32312866
https://pubmed.ncbi.nlm.nih.gov/32312866
Autor:
Lukas Mees, Moon K. Kim, Peter M. Thulé, Machelle T. Pardue, Nikita Pozdeyev, Darin E. Olson, P. Michael Iuvone, Moe H. Aung
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Electroretinograms (ERGs) are abnormal in diabetic retinas before the appearance of vascular lesions, providing a possible biomarker for diabetic vision loss. Previously, we reported that decreased retinal dopamine (DA) levels in diabetic rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ab9919d5142235a8e66412b353047b
https://pubmed.ncbi.nlm.nih.gov/29372256
https://pubmed.ncbi.nlm.nih.gov/29372256
Autor:
Miroslaw Kozlowski, Dingwu Jia, Darin E. Olson, Sara A. Paveglio, Yulin Lin, Peter M. Thulé, Adam G. Campbell, Shou You
Publikováno v:
The Journal of Gene Medicine. 17:141-152
Background Insulin self-administration is burdensome and can produce dangerous hypoglycemia. Insulin gene therapy may improve and simplify the treatment of diabetes mellitus. In rats, metabolically responsive hepatic insulin gene therapy (HIGT) deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb93a4b22a3d8ef068ad78b89bc9bdfe
https://doi.org/10.1002/jgm.2835
https://doi.org/10.1002/jgm.2835
Publikováno v:
Transplantation. 98:507-513
Background Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77069a699923e598bb9827b687575505
https://doi.org/10.1097/tp.0000000000000247
https://doi.org/10.1097/tp.0000000000000247
Autor:
Soumya Nalli, Dingwu Jia, Jyotirmay Sharma, Muhittin Onderci, Graham F. Barber, Collin J. Weber, Peter M. Thulé, Hong Yi, John Shires, Kereen Gordon, Susan A. Safley
Publikováno v:
World Journal of Surgery. 38:1251-1261
Insulin-secreting beta-like cells are vulnerable to diabetic autoimmunity. We hypothesized that human thyroid neuroendocrine (NE) cells could be engineered to secrete human insulin, be glucose-responsive, and avoid autoimmunity. Collagenase-digested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b53388597ef19eaaf6d96aeca562d4
https://doi.org/10.1007/s00268-014-2457-7
https://doi.org/10.1007/s00268-014-2457-7
Autor:
Rachael S Allen, Ryan Dunn, Cara Motz, Amy Ottensmeyer, Peter M. Thulé, Machelle T. Pardue, Andrew Feola, Kyle Chesler
Publikováno v:
Investigative Opthalmology & Visual Science. 60:123
Purpose To investigate the temporal appearance of retinal, cognitive, and motor deficits in Goto-Kakizaki (GK) rats, a spontaneously occurring, polygenic model of type II diabetes. GK rats develop impaired insulin secretion at 2 weeks and fasting hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042bcfa6a4f022e666e3fdfd395f7509
https://doi.org/10.1167/iovs.18-25110
https://doi.org/10.1167/iovs.18-25110
Publikováno v:
Proceedings of the National Academy of Sciences. 107:3323-3328
Therapeutic vascularization remains a significant challenge in regenerative medicine applications. Whether the goal is to induce vascular growth in ischemic tissue or scale up tissue-engineered constructs, the ability to induce the growth of patent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c041046e20fe00899dc79bc66157621
https://doi.org/10.1073/pnas.0905447107
https://doi.org/10.1073/pnas.0905447107
Autor:
Haiying Cheng, Yingxia Li, Xiaodong Zhang, Qiang Shen, Moon K. Kim, Darin E. Olson, Govind Nair, Peter M. Thulé, Timothy Q. Duong, Machelle T. Pardue
Publikováno v:
NMR in Biomedicine. 21:978-996
Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on magnetic resonance imaging (MRI) performed with spatial resolution sufficient to resolve multiple well-defined retinal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0868994fd89d31bd80edf54871ba6009
https://doi.org/10.1002/nbm.1311
https://doi.org/10.1002/nbm.1311
Autor:
Kimberly G. Freeman, Emily W Kelso, Darin E. Olson, Adam G. Campbell, William P. Flatt, Marty H Porter, Peter M. Thulé
Publikováno v:
Molecular Therapy. 16:1235-1242
Previous studies of hepatic insulin gene therapy (HIGT) focused on glycemic effects of insulin produced from hepatocytes. In this study, we extend the observations of glycemic control with metabolically regulated HIGT to include systemic responses an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85a343da17652e399f92fbc0fc5b508
https://doi.org/10.1038/mt.2008.97
https://doi.org/10.1038/mt.2008.97